Recombinant Human Gamma-interferon-inducible protein 16 (IFI16)

1. In humans with acute and chronic Hepatitis B exists activation of the AIM2 and IFI16 (in acute Hepatitis B), and the activation of the AIM2 and IFI16 can be inhibited by hepatitis B e antigen in chronic Hepatitis B. PMID: 30222506
2. Results suggest that interferon-gamma inducible factor 16 (IFI16) is essential for efficient sensing and signalling upon DNA challenge in macrophages to promote interferons and antiviral responses. PMID: 28186168
3. Data show that both cyclic GMP-AMP synthase (cGAS) and interferon-gamma inducible protein 16 (IFI16) are required for the activation of membrane protein STING (STING) and an innate immune response to exogenous DNA and DNA viruses. PMID: 28194029
4. Interferon-gamma induced protein IFI16 is a unique host factor protein involved in the EBV lifecycle. Reduction of IFI16 protein levels following lytic cycle induction, as well as reactivation from latency after IFI16 mRNA knockdown suggests that IFI16 is crucial for the maintenance of EBV latency. PMID: 29132393
5. This study found IFI16 and AIM2 SNPs associated with higher levels of periodontal microorganisms and an increased percentage of periodontal disease clinical parameters. PMID: 28387608
6. Importantly, knocking down p204, which is reported as the mouse orthologous of human IFI16, inhibited epidermal hyperplasia in mice with imiquimod-induced psoriasiform dermatitis. These findings indicate that IFI16 plays a critical role in the pathogenesis of psoriasis and may be a potential therapeutic target PMID: 27137868
7. IFI16 is a tumour suppressor in HCC via activation of p53 signals and inflammasome PMID: 28990231
8. in a cohort of patients with genital herpes and healthy controls, the minor G allele of the IFI16 single nucleotide polymorphism rs2276404 was associated with resistance to infection PMID: 28893956
9. study identifies the AIM2 inflammasome and cGAS/IFI16-STING-type I IFN pathway as a novel mechanism for host innate immunity to the ALVAC vaccine vector. PMID: 28947539
10. this study shows that IFI16 is not essential for the IFN response to human cytomegalovirus infection PMID: 27496731
11. findings show that IFI16 rapidly oligomerizes at incoming herpesvirus genomes at the nuclear periphery to transcriptionally repress viral gene expression and limit viral replicative capacity; further demonstrate that IFI16 does not initiate upstream activation of the canonical STING/TBK-1/IRF3 signaling pathway but is required for downstream antiviral cytokine expression. PMID: 27935834
12. The authors observed that a reduced IFI16 expression was associated with a very poor survival in chronic lymphocytic leukemia, but only in cases with ZAP70/CD38 expression. PMID: 28517553
13. Findings indicate that expression of the scleroderma autoantigens IFI-16 and CENPs, which are associated with severe vascular disease, is increased in vascular progenitors and mature endothelial cells. High level, lineage-enriched expression of autoantigens may explain the striking association between clinical phenotypes and the immune targeting of specific autoantigens. PMID: 27159521
14. DDR-induced signaling in cells activates the ATM-p53 and ATM-IKKalpha/beta-interferon (IFN)-beta signaling pathways, thus leading to an induction of the p53 and IFN-inducible IFI16 gene PMID: 27063514
15. These studies identify H2B as an innate nuclear sensor mediating a novel extra chromosomal function, and reveal that two IFI16 complexes mediate KSHV and HSV-1 genome recognition responses, with recognition by the IFI16-BRCA1-H2B complex resulting in IFN-beta responses and recognition by IFI16-BRCA1 resulting in inflammasome responses. PMID: 27764250
16. Overall, these data identify a novel activity of the pUL83/IFI16 interactome involved in the regulation of UL54 gene expression and IFI16 stability during early and late phases of human cytomegalovirus replication. PMID: 27384655
17. Together, these results demonstrate that herpes simplex virus 1 promotes the loss of IFI16 through at least two mechanisms: (i) by ICP0-dependent degradation of IFI16 and (ii) by vhs-dependent turnover of IFI16 mRNA. PMID: 27412599
18. These results reveal that Kaposi's sarcoma-associated herpesvirus utilizes the innate immune nuclear DNA sensor IFI16 to maintain its latency and repression of lytic transcripts, and a late lytic Kaposi's sarcoma-associated herpesvirus gene product(s) targets IFI16 for degradation during lytic reactivation. PMID: 27466416
19. Data show that NOD-like receptor signaling genes NOD2, PYCARD, CARD6, and IFI16 are upregulated in psoriatic epidermis. PMID: 26976200
20. By combining biochemical assays and single-molecule techniques, the authors show that the nuclear innate immune sensor IFI16 one-dimensionally tracks long stretches of exposed foreign dsDNA to assemble into supramolecular signaling platforms. PMID: 26673078
21. High levels of circulating IFI16 in rheumatoid arthritis are more frequent in RF/anti-CCP-positive RA patients and significantly associated with pulmonary involvement. PMID: 26316393
22. A significant upregulation of the PYHIN inflammasomes AIM2 and IFI16 in active inflammatory bowel disease versus controls was found. PMID: 26313692
23. Results provide mechanistic insights into the regulation of IFI16 during HSV-1 infection and show interactions with ICP0 and PML-containing ND10 bodies that can contribute to IFI16 antiviral functions. PMID: 25693804
24. antibodies prominent in primary Sjogren's syndrome PMID: 26037655
25. Studies of the dynamics of the response of PML nuclear body components and IFI16 to invading herpes simplex virus 1 genomes demonstrated that human Daxx (hDaxx) and IFI16 respond more rapidly than PML. PMID: 26468536
26. These findings demonstrate that IFI16 plays a critical role in fms-like tyrosine kinase 1 and soluble endoglin production in human trophoblast cells. PMID: 26002845
27. IFI16 sera concentration was directly correlated with disease duration and inversely correlated with age at diagnosis of Sjogren's syndrome. PMID: 26271464
28. increased nuclear acetylation of IFI16 is a dynamic essential post-genome recognition event in the nucleus that is common to the IFI16-mediated innate responses of inflammasome induction and IFN-beta production during herpesvirus infections PMID: 26134128
29. BRCA1 is a constituent of the triggered IFI16-inflammasome and is translocated into the cytoplasm after genome recognition along with the IFI16-inflammasome PMID: 26121674
30. IFI16 gene expression directly correlated with NF-kappaB activation, indicating that IFI16 could be considered an upstream modulator of NF-kappaB in human B-cells. PMID: 26185770
31. The etracellular protein induces inflammation in endothelial cells via p38 MAPK and NF-kappaB p65 activation. PMID: 25715050
32. presence of circulating IFI16 in sera from systemic autoimmune patients indicates it may be mislocalized from its nuclear site and secreted in extracellular milieu; review discusses leakage of endogenous IFI1 and comments on significance of mislocalized inflammasome components in extracellular space and how it can be responsible for chronic inflammation PMID: 25466628
33. Our findings suggest association of IFI16, a cytosolic sensor of dsDNA and mediator of the AIM2 inflammasome-dependent pathway, in susceptibility to Behcet disease. PMID: 25641891
34. these studies for the first time demonstrate that IFI16 prevents association of important transcriptional activators with wt HSV-1 promoters PMID: 25375629
35. IFI16 inhibits HPV18 replication by repressing viral-gene expression and replication. PMID: 25972554
36. Nutlin-3 regulates the subcellular localization of IFI16 in HCC cells in vitro in a p53-dependent manner. PMID: 25544361
37. Single nucleotide polymorphism rs1417806 in IFI16 is associated with CD4(+) T-cell counts at set point and HIV-1 disease progression. PMID: 25363454
38. IFI16 and cGAS cooperate in a novel way to sense nuclear herpesviral DNA and initiate innate signaling PMID: 25831530
39. IFI16 activated innate immunity and viral restriction against Herpesviruses and Lentiviruses. [review] PMID: 25742143
40. results indicate a broader role for IFI16 in the regulation of the type I IFN response to RNA and DNA viruses in antiviral immunity PMID: 25002588
41. present our study and theoretical basis and presume that chromatin-bounding localization of IFI16 is associated with HCC progression PMID: 24491427
42. Listeria monocytogenes infection correlates with expression of IFI16. PMID: 24970844
43. HCMV has evolved mechanisms to mislocalize and hijack IFI16, trapping it within mature virions. PMID: 24696486
44. The results of this study showed that IFI16 variants do not contribute to multiple sclerosis susceptibility. PMID: 24794504
45. these data demonstrate a correlation between IFI16 and CD38 expression, a marker of immune activation, in CD4(+) central and effector memory T cells, which may indicate that IFI16-mediated DNA sensing and signalling contributes to chronic immune activation. PMID: 24593816
46. HPV 16 infection induce upregulation of HER2/neu, pStat3 and IFI16. PMID: 24858640
47. Cytomegalovirus pUL83 disrupts human IFI16 by concerted action of its N- and C-terminal domains, in which an evolutionarily conserved N-terminal pyrin association domain (PAD) binds IFI16. PMID: 24237704
48. Our results show that HSV2 is detected by a plethora of PRRs including interferon-inducible 16, which trigger cytokine secretion to protect the host. PMID: 24080302
49. IFI16 clusters into signaling foci in a switch-like manner, and it is capable of using the size of naked dsDNA as a molecular ruler to distinguish self from nonself PMID: 24367117
50. this identifies interferon-gamma-inducible protein 16 (IFI16) as a host DNA sensor required for CD4 T cell death due to abortive HIV infection. PMID: 24356113

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HGNC: 5395

OMIM: 147586

KEGG: hsa:3428

STRING: 9606.ENSP00000357113

UniGene: Hs.380250