Gamma-interferon-inducible protein 16 is a protein in humans that is encoded by IFI16 gene. Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy.
The following IFI16 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
IFI16 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA586413 | IFI16 Antibody |
Human | ELISA,WB |
CSB-PA009445 | IFI16 Antibody |
Human | WB, ELISA |
IFI16 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP620975HU CSB-EP620975HU CSB-BP620975HU CSB-MP620975HU CSB-EP620975HU-B |
Recombinant Human Gamma-interferon-inducible protein 16 (IFI16) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IFI16 Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Code | Product Name | Source |
---|---|---|
CSB-YP719265PYX CSB-EP719265PYX CSB-BP719265PYX CSB-MP719265PYX CSB-EP719265PYX-B |
Recombinant Pongo abelii Gamma-interferon-inducible protein 16 (IFI16), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |