Code | CSB-EP009911HU |
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Size | $388 |
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The DNA fragment encoding the 19-559aa of the human GRIN1 protein was fused with N-terminal 6xHis tag gene and then was inserted into the expression vector, which was subsequently transformed into the E.coli for expression. The resulting product was further purified to obtain the recombinant human GRIN1 protein. The purity of this recombinant GRIN1 protein is greater than 90% assessed by Bandscan software analysis combined with SDS-PAGE. This recombinant GRIN1 protein showed a band on the gel with a molecular weight of approximately 60 kDa.
As a novel protein of neuromuscular junction and brain, GRIN1 plays essential roles including learning, memory, and synaptic plasticity. For Alzheimer's disease (AD), GRIN1 recently has been found to play a role in regulation of AD pathway. For Parkinson's disease (PD), gene co-expression network analysis identifies that hub gene GRIN1 is related to Parkinson's disease. GRIN1 that interacts with SLC18A2 is involved in the interaction of neuroactive ligand receptors. Others suggested that GRIN1 can be associated with PD in early or later stages.
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I'm interested in CSB-EP009911HU however, I would like the same buffer from CSB-EP626478EQV, lot# 03797 (0.2 μm sterile filtered 10 mM Tris-HCl, 1 mM EDTA, pH 8.0, 20% glycerol).
Can you guarantee to provide this buffer?
Another question:
“Is it possible to express the tag only in E.Coli and provide it in the same buffer? If yes, which would be the cost?”
Given that the Tag is 6XHis, I assume the lab would not be able to express the 6XHis Tag alone because it is too small, but I want to confirm with you.