Recombinant Human Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B)

1. The assessment of the interaction between GADD45beta and MKK7 and the elucidation of the recognition surfaces between DTP3 and MKK7 significantly advance the understanding of the mechanism underlying the inhibition of the GADD45beta/MKK7 interaction by DTP3 and pave the way to the design of small-molecule DTP3 analogues. PMID: 29572137
2. We propose a signaling cascade involving ARID1A, GADD45B and DUSP1 as mediators of the romidepsin effects in GCC cells. PMID: 27572311
3. present study provides evidence that variations in GADD45B rs2024144T, MAPK14 rs3804451A and GADD45A rs581000C may predict platinum-based chemotherapy toxicity outcomes in patients with advanced non-small cell lung cancer PMID: 26993769
4. These findings demonstrate that 19p13.3-GADD45B rs7354 variant and interaction between 19p13.3-GADD45B rs3783501 and 19q13.3-CD3EAP rs967591 may play a role in association with smoke-exposed lung cancer among Chinese. PMID: 28870783
5. We used a new approach to search for human genes repressed by small nucleic acids (microRNAs) expressed by a gammaherpesvirus (KSHV), which identified a gene called GADD45B as a target of microRNAs. Repression of GADD45B, which is expressed in response to DNA damage, benefited survival of infected cells in response to a DNA damage response. This information could be used to design new treatments for herpesvirus infections PMID: 27852859
6. Gadd45beta could be a suitable biomarker of cardiomyocytes apoptosis in newborns experiencing hypoxia in the first day of life, as its highest tissue immunoexpression around at the first six hours after birth. PMID: 28214215
7. Nrf2-Gadd45b signaling axis exhibited a protective role in antimony trioxide-induced cell apoptosis. PMID: 27208483
8. our data demonstrate that C/EBPbeta plays a central role in controlling Gadd45beta gene expression in articular chondrocytes PMID: 26896926
9. The gadd45b gene has both tumor suppressor and tumor promoter functions, dependent on the tissue/cell type and transforming event. (Review) PMID: 24104471
10. Gadd45B protects the liver through two entirely different processes: binding MKK7 to block damaging signal transduction or binding CAR to coactivate anabolic transcription. (Review) PMID: 24104474
11. as such may play an unappreciated role in tumorigenesis. The exact mechanism of GADD45B inactivation and overexpression requires further investigation. GADD45B could be a potential therapeutic target for CRC treatment in future PMID: 23110778
12. Cadmium chloride can induce DNA damage and increase expression levels of the gadd153 and gadd45beta promoters in HepG2 cells. PMID: 22096849
13. finding show there is an increased expression and decreased promoter binding of GADD45b in psychotic subjects. PMID: 22048458
14. GADD45beta is a novel pituitary tumor suppressor whose reexpression blocks proliferation, survival, and tumorigenesis PMID: 21810943
15. The association of GADD45beta expression and pathological grading of chondrosarcoma in the present study suggests that the immunohistochemical study of GADD45beta may be a specific diagnostic parameter for chondrosarcoma cell differentiation. PMID: 20942912
16. PXR activates the GADD45beta gene, increasing p38 MAPK phosphorylation, and leading HepG2 cells to change morphology and migrate. PMID: 21127053
17. Findings suggest that GADD45beta induction contributes to sorafenib-induced apoptosis in HCC cells, prompting further studies to validate its potential value in predicting sorafenib efficacy. PMID: 21062976
18. Findings suggest that Gadd45b mediates p38-induced Rb phosphorylation by enhancing the interaction between p38 and Rb during Fas-induced apoptosis in murine hepatocytes. PMID: 20558744
19. The stress-mediated induction of gadd45b by distinct stressors is differentially regulated at the level of mRNA transcription or mRNA stability, which is largely distinct from gadd45a. PMID: 19834918
20. Diminished Gadd45beta expression leads to aberrant cell cycle arrest and diminished DNA excision repair and is associated with HCV-associated hepatocellular carcinomas. PMID: 20530689
21. participation of NF-kappaB in the regulation of Gadd45beta PMID: 12162804
22. Results suggest that GADD45beta, which is down-regulated in most cases of hepatocellular carcinoma (HCC), remains an ideal candidate for development as a molecular marker in the diagnosis of HCC and as a potential therapeutic target. PMID: 12759252
23. in B cells, Gadd45 beta is induced by CD40 through a mechanism that requires NF-kappa B and that induction suppresses Fas-mediated killing PMID: 12855571
24. SMAD3 and SMAD4 activate gadd45beta through its third intron to facilitate G2 progression following TGFbeta treatment PMID: 14630914
25. methylation might play a crucial role in the epigenetic regulation of GADD45beta in hepatocyte transformation that may be directed by p53 status PMID: 15509538
26. TGF-beta induces biglycan expression through ALK5 and GADD45beta PMID: 15546867
27. NF-kappaB, ERK, and GADD45beta are able to coordinate in a loop-like signaling network to defend cells against the cytotoxicity induced by ionizing radiation PMID: 15642734
28. GADD45beta plays an essential role during chondrocyte terminal differentiation and mediates MMP-13 gene expression PMID: 16144844
29. We found significant differences in gene expression, specifically with a group of genes, including GADD45beta, known to be responsive to estrogen or to interact with estrogen receptor. PMID: 17437852
30. Association of Gadd45beta with MKK7 involves a network of interactions mediated by its putative helices alpha3 and alpha4 and loops 1 and 2 PMID: 17485467
31. our results suggest that GADD45beta induction by SAMe via NF-kappaB may represent a novel mechanism of SAMe-mediated hepatoprotection, with p53 playing an important role. PMID: 17591973
32. The results suggest the occurrence of a large complex containing at least an MKK7-Gadd45 beta:Gadd45 beta-MKK7 tetrameric unit whose complexity could be further increased by the dimeric nature of the isolated MKK7. PMID: 18343408
33. Haplotype (rs2024144-rs3783501) of GADD45B affected the thickness of inter-ventricular septum in patients with hypertrophy cardiomyopathy. PMID: 18515079
34. These observations suggest that GADD45beta might play an important role in regulating chondrocyte homeostasis by modulating collagen gene expression and promoting cell survival in normal adult cartilage and in early OA PMID: 18576389
35. Deficient Gadd45beta expression in RA can contribute to activation of JNK, exacerbate clinical arthritis, and augment joint destruction. PMID: 19877043

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HGNC: 4096

OMIM: 604948

KEGG: hsa:4616

STRING: 9606.ENSP00000215631

UniGene: Hs.110571