Recombinant Human HLA class I histocompatibility antigen, alpha chain E (HLA-E), partial

1. Data suggest that, although different T-cell receptors adopt distinct docking modes on HLAE, energetic basis of T-cell receptor interaction is defined by set of conserved HLAE residues. PMID: 28972140
2. It indicates that HLA-E expression may have an immunomodulatory effect and a possible role in the severity of liver disease in chronic hepatitis C. PMID: 29951556
3. HLA-E is highly represented in ovarian carcinoma suggesting a potential association with progressive disease mechanism PMID: 29499226
4. Soluble HLA-E level is useful as a biomarker of disease activity and course in Takayasu arteritis patients. rs1264457 polymorphism is neither associated with susceptibility nor did it influence sHLA-E levels in TA. PMID: 28425192
5. The frequency of the HLA-E*0101/*0103X genotype in male patients with Pemphigus Vulgaris was found to be significantly higher than in men in the control group (P=0.023). PMID: 29252170
6. These data suggest that HLA-E overexpression frequently occurs in renal cell carcinoma and correlates with reduced immunogenicity PMID: 27589686
7. HLA-E restricted CD8+ T cells may represent an important subset of pTregs, suppressing previously activated target cells. PMID: 24144875
8. No specific HLA-G and HLA-E haplotypes were significantly associated with increased risk of developing severe preeclampsia/eclampsia. PMID: 27596021
9. Our findings provide evidence that during renal allograft rejection HLA-E along with high numbers of mismatched HLA-class I leader peptides might represent additional targets for immune-activating responses. PMID: 27871782
10. The results suggest that HLA-E allelic variants may play a role in the modulation of immune responses in the context of the inability of natural conception and establishment of a viable pregnancy. PMID: 27714943
11. The prognostic benefit of natural killer cells, but not T-cells, is influenced by HLA-E expression in endometrial cancer. PMID: 29059634
12. This data reinforces the presence of only two main full-length HLA-E molecules encoded by the many HLA-E alleles detected in our population sample. In addition, this data does indicate that the distal HLA-E promoter is by far the most variable segment. PMID: 28946074
13. HLA-E alleles and sHLA-E levels may represent novel biomarkers for early disease progression in patients with chronic lymphocytic leukemia PMID: 27859015
14. In insulitic islets from living patients with recent-onset T1D, most of the overexpressed ISGs, including GBP1, TLR3, OAS1, EIF2AK2, HLA-E, IFI6, and STAT1, showed higher expression in the islet core compared with the peri-islet area containing the surrounding immune cells PMID: 27422384
15. soluble HLA-Ib molecules HLA-G and HLA-E are present in BM plasma samples in physiological and pathological conditions, and their concentration correlated with stage disease in NB patients. PMID: 27610393
16. this study shows the high expression of HLA-E in actinic chelitis and in lip squamous cell carcinoma, which reflects the capacity that these pathologies have for evasion and progression PMID: 26723902
17. Our study reveals that HLA-E polymorphism is associated with nasopharyngeal cancer. PMID: 26896927
18. High expression of HLA-E is associated with non-small cell lung carcinoma. PMID: 26658106
19. The positive correlation has been found between the HLA-E*01:01/01:03 A>G polymorphism, plasma HLA-E level, and advanced fibrosis stages in chronic hepatitis B patients. PMID: 26956431
20. the promoter region of the HLA-E gene presents few and rare variable sites in Brazilian population sample. PMID: 26596885
21. HLA-E regulates NKG2C+ natural killer cell function through presentation of a restricted peptide repertoire PMID: 26382247
22. HLA-E is capable of presenting a highly conserved peptide from HIV-1 capsid (AISPRTLNA) that is not recognized by NKG2A/CD94. PMID: 26828202
23. over-expression of HLA-E is associated with melanoma PMID: 26090591
24. Peptide-induced HLA-E expression in human PBMCs is dependent on peptide sequence and the HLA-E genotype. PMID: 25735891
25. this study suggests that minor histocompatibility antigens presented by HLA-E can represent an additional risk factor following lung transplantation. PMID: 26302084
26. These results indicate that E*01:01 is a novel protective genetic factor in EBV-associated cHL and support a role for HLA-E recognition on the control of EBV infection and lymphomagenesis. PMID: 26261988
27. HLA-E molecules traffic differently from the HLA-class I molecules and can play a fundamental role in the protection against intracellular pathogens and susceptibility to several diseases. PMID: 26310830
28. Functional differences and the immunological impact of HLA-E allelic variant Arg107Gly PMID: 26552660
29. increased risk of recurrent miscarriage in mothers carrying HLA-E*01:01 allele; meta-analysis PMID: 25700963
30. The results derived from this study imply that HLA-E polymorphisms may influence RA susceptibility and affect clinical outcome of anti-TNF therapy in female RA patients. PMID: 26307125
31. genetic polymorphism is not associated with nasopharyngeal carcinoma in China PMID: 25636564
32. genetic polymorphism does not affect treatment outcome following allogeneic hematopoietic stem cell transplantation in Egyptian patients PMID: 25543014
33. Monoclonal antibodies to HLA-E bind epitopes carried by unfolded beta2 m-free heavy chains. PMID: 25982269
34. We identified that the HLA-E and HLA-F in gastric cancer independently affected clinical factors, including postoperative outcome PMID: 25862890
35. HLA-E gene polymorphisms are associated with the development of breast cancer in women of Han polulation. PMID: 25854574
36. HLA-E*0103 allele is associated with susceptibility to serous ovarian cancer in a Chinese Han population. PMID: 25711417
37. Review of the impact of human leukocyte antigen molecules E, F, and G on the outcome of transplantation. PMID: 25420801
38. IL-12-producing monocytes and HLA-E control HCMV-driven NKG2C+ NK cell expansion. PMID: 25384219
39. novel insights in the mechanism via which HLA-E expression levels are controlled and how the cellular immune response in transplantation and cancer is influenced by HLA-E. PMID: 25413103
40. Results show that HLA-E and KIR2DL4 demonstrate evidence of positive selection between human, chimpanzee and gorilla suggesting a main role for immunological adaptations linked to embryo deep invasion of the maternal endometrium during pregnancy. PMID: 25451741
41. Studies suggest that HLA class I molecule HLA-E to be a ligand for the innate and adaptive immune system. PMID: 25401109
42. Sera from early-onset, severely preeclamptic women directly modulate HLA-E expression in the EA.hy296 endothelial cell line. PMID: 24837231
43. Findings indicate that HLA-E up-regulation in 3D-cultured cells may result in enhanced tumor resistance to NK cell-mediated immune response. PMID: 24742303
44. The expression levels of HLA-G or HLA-E alone and the combined expression of both molecules were all statistically correlated with the overall survival of colorectal cancer patients. PMID: 25461612
45. Transgenic hCD46/HLA-E expression reduced humoral xenoresponses since all were downregulated during ex vivo xenoperfusion of hCD46/HLA-E double transgenic pig forelimbs with human blood. PMID: 24635052
46. IL-27 driven upregulation of surface HLA-E expression on monocytes inhibits IFN-gamma release by autologous NK cells. PMID: 24741633
47. NKG2C receptor deletion and a functional polymorphism in its ligand HLA-E may play a role in psoriasis susceptibility PMID: 24079744
48. surface HLA-E was higher on melanoma cells than on melanocytes and protected the former (6/6 cell lines) from lysis by natural killer (NK) cells, functionally counteracting co-expressed triggering ligands. PMID: 24011128
49. These results indicate that generating transgenic HLA-E pigs might protect porcine grafts from, not only NK cytotoxicity, but also macrophage-mediated cytotoxicity. PMID: 23994719
50. Data suggest that the cell-surface HLA class I molecules HLA-E, HLA-C, and HLA-G co-localize with each other on trophoblast cell membranes and have the potential to form preferential heterotypic associations that may be modulated by progesterone. PMID: 24006284

Show More

Hide All

HGNC: 4962

OMIM: 143010

KEGG: hsa:3133

STRING: 9606.ENSP00000365817

UniGene: Hs.650174