Recombinant Human Hepatic sodium/bile acid cotransporter (SLC10A1), partial, Biotinylated

1. we review the current knowledge of the functional role and the molecular and cellular biology of NTCP in the life cycle of the three major hepatotropic viruses, highlight the impact of NTCP as an antiviral target and discuss future avenues of research PMID: 30097692
2. In this study, the authors identified new hepatitis B virus isolates from one homozygous S267F NTCP mutation carrier and confirmed new isolates also use wildtype-NTCP as a cellular receptor. Furthermore, we demonstrated S267F variant of NTCP, though inefficient, is still a functional receptor for hepatitis B virus entry. PMID: 30032030
3. These findings suggest that host factors unique to HepaRG cells are required for efficient infection by serum-derived HBV, and factors other than NTCP contribute to balanced viral antigen production following infection by cell culture-derived HBV. PMID: 29793953
4. These kinetic results provide important complementary data on the substrate selectivity and specificity of NTCP to transport bile acids. PMID: 29024779
5. Results show that NTCP inhibition suppressed the in vivo spread of HBV infection in the presence of uninfected hepatocytes. Livers in CHB patients contained varying degrees of HBsAg-negative hepatocytes, as evidenced by immunohistochemistry. PMID: 27278060
6. These results uncover NTCP as a mediator of innate antiviral immune responses in the liver. PMID: 27783949
7. For Tibetans and Uygurs, no association of the three NTCP SNPs (rs7154439, rs4646287 and rs2296651) and their haplotypes with hepatitis B virus chronicity was observed. PMID: 27051045
8. the present study indicated that the common variants in the regulatory elements of NTCP may not influence the expression level of SLC10A1 at transcriptional regulation, and ultimately may not be associated with HBV susceptibility. PMID: 27491457
9. The data showed that S267F of sodium taurocholate cotransporting polypeptide is not associated with hepatitis B virus infection, and is not prevalent in the general Moroccan population. PMID: 28125961
10. The SLC10A1 (NTCP) S267F variant is independently associated with decreased risk of progression to Liver cirrhosis and Hepatocellular Carcinoma , and resistance to Chronic Hepatitis B infection. PMID: 26642861
11. In conclusion, NTCP appeared inefficient to mediate infection by serum-derived hepatitis B virus. PMID: 27384660
12. Computer screening of NTCP inhibitors and non-inhibitors showed no relationship between the drugs and drug induced liver injury. PMID: 25220493
13. We found a genetic variant (rs4646287) located in intron 1 of NTCP that may be associated with increased risk of HBV infection in Han Chinese PMID: 26968990
14. The observation that the pharmacological inhibitors of the NTCP transporter could block HBV entry suggests that NTCP represents an attractive molecular target for therapeutic intervention in HBV infection. PMID: 25929767
15. Hepatitis B virus efficiently infects non-adherent hepatoma cells via NTCP, which functions as a virus receptor. PMID: 26592202
16. We describe for the first time a mouse liver cell line that, solely upon expression of the hNTCP receptor, becomes susceptible to HBV. PMID: 26865711
17. This study suggests that polymorphisms in the NTCP region may be associated with the natural course of HBV infection. PMID: 25010264
18. Liver nuclear receptors, FXR and SHP, and bile acid transporters, NTCP and BSEP, are associated with the progression of NAFLD. PMID: 26019035
19. Interleukin 6 inhibits HBV entry through downregulation of NTCP. PMID: 25765005
20. NTCP is a functional receptor for hepatitis B virus and hepatitis D virus. PMID: 25409679
21. NTCP polymorphism play a critical role in the individual variability of rosuvastatin pharmacokinetics in Chinese healthy males PMID: 25985569
22. NTCP is a functional receptor for human hepatitis B and D virus. PMID: 23150796
23. hNTCP is an electrogenic Na(+)-dependent transporter PMID: 25168282
24. findings suggest that the rs2296651 polymorphism in NTCP may predispose the susceptibility to and chronicity of HBV infection PMID: 24735529
25. Viral entry of hepatitis B and D viruses and bile salts transportation share common molecular determinants on NTCP. PMID: 24390325
26. Human NTCP is a specific receptor for hepatitis B and D viruses, allowing virus entry into hepatocytes. PMID: 24361467
27. Polymorphisms in CYP2C9, CYP2C19 and SLC10A1 had minimal lipid-lowering effects. PMID: 23930675
28. Knockdown analysis suggested that HBV infection of HepG2-hNTCP-C4 cells was mediated by NTCP. PMID: 24342612
29. This study was conducted to determine which of the 8 cysteine residues of NTCP is responsible for nitric oxide-mediated S-nitrosylation and inhibition of taurocholate uptake. PMID: 23886862
30. Data suggest that, in SLC10A1, amino acid residues along one face of transmembrane domain 5 do not play direct role in substrate transport but are critical for sodium/bile acid transport functions of SLC10A1, most likely through helical stability. PMID: 23815591
31. these results suggest that the plasma membrane localization rather than kinase activity of PKCdelta plays an important role in cAMP-induced NTCP translocation and Rab4 activity PMID: 22744337
32. Patients undergoing partial hepatectomy with low post-operative bilirubin had lower levels of NTCP, MDR3 and BSEP mRNA compared to those with high bilirubin after Pringle manoeuvre. PMID: 22098322
33. NTCP adopts a dimeric structure in which individual subunits are functional. Bile salt uptake is influenced by heterodimerization when this impairs NTCP plasma membrane trafficking. PMID: 22029531
34. essential role of Na+-taurocholate co-transporting polypeptide (NTCP) in the uptake of bile acids, by which the enterohepatic recirculation of bile acids is maintained PMID: 21341987
35. Inhibition of taurocholate uptake by nitric oxide involves S-nitrosylation of NTCP. PMID: 21109590
36. The mRNA expression levels of sodium taurocholate cotransporting polypeptide, bile salt export pump, and hepatic cholesterol 7alpha-hydroxylase were significantly higher in the primary biliary cirrhosis patients than in the controls. PMID: 20857261
37. Translation/insertion scanning, alanine insertion, and glycosylation site mutagenesis studies of liver sodium/bile acid cotransporter support a topography with nine membrane-spanning or membrane-associated segments. PMID: 12044156
38. a domain critical for bile acid substrate recognition of SLC10A1 has an ethnicity-dependent polymorphism PMID: 14660639
39. Conserved NTCP/Ntcp 5'-regulatory region transcription regulation differs among species and is not directly regulated by small heterodimer partner. Bile acids may regulate NTCP/Ntcp indirectly by modulating nuclear factor regulation of gene expression. PMID: 14701722
40. The present studies were undertaken to establish a suitable in vitro experimental model to study human ASBT function and its regulation by cholesterol. PMID: 15604201
41. The major canalicular transporter genes are expressed at mid-gestational stage during human fetal development. PMID: 15922475
42. Results suggest that the Ser-226 in the third cytoplasmic loop of NTCP is phosphorylated and cAMP may increase NTCP translocation to the cell membrane by dephosphorylating NTCP at this site. PMID: 16027164
43. The GR/dexamethasone activation of the hNTCP promoter is counteracted by bile acids and small heterodimer partner, providing a negative feedback mechanism for bile acid uptake in human hepatocytes. PMID: 16123152
44. Cholesterol treatment led to increased levels of NTCP and OCT-1 mRNAs. PMID: 17635184

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HGNC: 10905

OMIM: 182396

KEGG: hsa:6554

STRING: 9606.ENSP00000216540

UniGene: Hs.952