Recombinant Human Interleukin-4(IL-4)

Code CSB-EP011659HU
Product Type Recombinant Protein
Size US$1726
Uniprot No. P05112
Relevance Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Storage Buffer Tris-based buffer,50% glycerol
Alias B-cell stimulatory factor 1
Species Homo sapiens (Human)
Purity Greater than 90% as determined by SDS-PAGE.
Sequence HKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAASKNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGLNSCPVKEANQSTLENFLERLKTIMREKYSKCSS
Source E.coli
Gene Names IL4
Protein Names Recommended name: Interleukin-4 Short name= IL-4Alternative name(s): B-cell stimulatory factor 1 Short name= BSF-1 Binetrakin Lymphocyte stimulatory factor 1 Pitrakinra
Expression Region 25-153aa
Tag Info N-terminal 6xHis-SUMO-tagged
Mol. Weight 31.0kDa
Protein Description Full Length of Mature Protein
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Participates in at least several B-cell activation processes as well as of other cell types
Involvement in disease Ischemic stroke (ISCHSTR)
Subcellular Location Secreted
Protein Families IL-4/IL-13 family
Database Links

HGNC: 6014

OMIM: 147780

KEGG: hsa:3565

STRING: 9606.ENSP00000231449

UniGene: Hs.73917

Pathway Jak-STAT signaling pathway
PI3K-Akt signaling pathway
Fc epsilon RI signaling pathway
Hematopoietic cell lineage
IL-17 signaling pathway
T cell receptor signaling pathway
Th1 and Th2 cell differentiation
Th17 cell differentiation

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