Recombinant Human Leukocyte immunoglobulin-like receptor subfamily A member 3 (LILRA3)

1. Mutations in the genes glucokinase regulatory protein (GCKR), RNase L (RNASEL), leukocyte immunoglobulin-like receptor 3 (LILRA3), and dynein axonemal heavy chain 10 (DNAH10) segregated with elevated HDLc levels in families, while no mutations associated with low HDLc. PMID: 24891332
2. The homozygous LILRA3 deletion is associated with a higher susceptibility for HIV disease and with a faster disease progression. PMID: 27755104
3. Letter: LILRA3 gene deletion is not involved in the giant cell arteritis and systemic sclerosis predisposition in Spanish patients. PMID: 27462831
4. LILRA3 significantly reversed Nogo-66-mediated inhibition of neurite outgrowth and promoted synapse formation in primary cortical neurons through regulation of the ERK/MEK pathway. PMID: 26826187
5. Experiments point towards a beneficial role for LILRA3 in virus infections, especially in ssRNA viruses, like HIV, that engage TLR8; however, the potentially beneficial role of LILRA3 is abrogated during a HIV infection. PMID: 26969150
6. LILRA3 gene deletion was not associated with Multiple Sclerosis susceptibility and did not affect the age of disease onset, clinical subtype or disease severity. PMID: 26871720
7. Evidence showed lack of significant association between LILRA3 deletion and multiple sclerosis pathogenesis. [meta-analysis] PMID: 26274821
8. LILRA3 is a new susceptibility factor for systemic lupus erythematosus (SLE) and primary Sjogren's syndrome (pSS). It predisposes to certain phenotypes such as leucopenia, thrombocytopenia, autoantibody positivity and increased disease activity. PMID: 24906639
9. The current study was conducted to investigate the association of rs103294 of LILRA3 with benign prostatic hyperplasia risk. PMID: 23615473
10. ILT6 deletion polymorphism does not appear to be a lupus susceptibility gene in South Indian Tamils, but may behave as a genetic modifier of autoantibody phenotype by influencing the production of anti-Ro60 and anti-Ro52 autoantibodies PMID: 24899637
11. LILRA3 is an immunostimulatory molecule, whose deficiency is associated with higher frequency of B-non-Hodgkin's lymphoma. PMID: 24363809
12. functional LILRA3 is a novel genetic risk factor for rheumatoid arthritis (RA), especially in males. It appears to highly predispose to ACPA-positive RA and confers an increased risk of disease severity in patients with early RA. PMID: 24757135
13. Data did not indicate any association of LILRA3 deletion with multiple sclerosis (MS) susceptibility, however, patients negative for the deletion may begin to suffer from MS significantly earlier than patients who are positive. PMID: 23238213
14. LILRA1 and LILRA3 generally display a greater binding preference for binding to HLA-C free heavy chain, particularly following removal of beta2-microglobulin by acid treatment. PMID: 21270408
15. These results suggest that LILRA3 may play a role in chronic inflammatory conditions such as rheumatoid arthritis. PMID: 20595277
16. A deletion of LILRA3 gene was found in a minority of British population PMID: 12651072
17. Six alleles characterised, of which four will encode unique peptides, one of which is likely to directly influence ligand binding. PMID: 12750859
18. Multiple sclerosis associates with LILRA3 deletion. PMID: 19421224
19. ILT6 deficiency may be a genetic risk factor for Sjogren's syndrome. PMID: 19790059

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HGNC: 6604

OMIM: 604818

KEGG: hsa:11026

STRING: 9606.ENSP00000251390

UniGene: Hs.113277