LILRA3 Antibody

Code CSB-PA836677LA01HU
Size US$166
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Image
  • Western Blot
    Positive WB detected in: A549 whole cell lysate, Jurkat whole cell lysate
    All lanes: LILRA3 antibody at 4.2µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 48, 41, 50 kDa
    Observed band size: 48 kDa

  • IHC image of CSB-PA836677LA01HU diluted at 1:300 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) LILRA3 Polyclonal antibody
Uniprot No.
Target Names
LILRA3
Alternative Names
CD 85E antibody; CD85 antigen-like family member E antibody; CD85e antibody; CD85e antigen antibody; e3 antibody; HM 31 antibody; HM 43 antibody; HM31 antibody; HM43 antibody; ILT 6 antibody; ILT-6 antibody; ILT6 antibody; Immunoglobulin like transcript 6 antibody; Immunoglobulin-like transcript 6 antibody; Leucocyte immunoglobulin like receptor antibody; Leukocyte immunoglobulin like receptor 4 antibody; Leukocyte immunoglobulin like receptor A3 antibody; Leukocyte immunoglobulin like receptor subfamily A (without TM domain) member 3 antibody; Leukocyte immunoglobulin like receptor subfamily A member 3 antibody; Leukocyte immunoglobulin-like receptor 4 antibody; Leukocyte immunoglobulin-like receptor subfamily A member 3 antibody; LILRA 3 antibody; LILRA3 antibody; LIR 4 antibody; LIR-4 antibody; LIR4 antibody; LIRA3_HUMAN antibody; Monocyte inhibitory receptor HM43/HM31 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Leukocyte immunoglobulin-like receptor subfamily A member 3 protein (222-313AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The LILRA3 Antibody (Product code: CSB-PA836677LA01HU) is Non-conjugated. For LILRA3 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA836677LB01HU LILRA3 Antibody, HRP conjugated ELISA
FITC CSB-PA836677LC01HU LILRA3 Antibody, FITC conjugated
Biotin CSB-PA836677LD01HU LILRA3 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:200-1:500
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes.
Gene References into Functions
  1. Mutations in the genes glucokinase regulatory protein (GCKR), RNase L (RNASEL), leukocyte immunoglobulin-like receptor 3 (LILRA3), and dynein axonemal heavy chain 10 (DNAH10) segregated with elevated HDLc levels in families, while no mutations associated with low HDLc. PMID: 24891332
  2. The homozygous LILRA3 deletion is associated with a higher susceptibility for HIV disease and with a faster disease progression. PMID: 27755104
  3. Letter: LILRA3 gene deletion is not involved in the giant cell arteritis and systemic sclerosis predisposition in Spanish patients. PMID: 27462831
  4. LILRA3 significantly reversed Nogo-66-mediated inhibition of neurite outgrowth and promoted synapse formation in primary cortical neurons through regulation of the ERK/MEK pathway. PMID: 26826187
  5. Experiments point towards a beneficial role for LILRA3 in virus infections, especially in ssRNA viruses, like HIV, that engage TLR8; however, the potentially beneficial role of LILRA3 is abrogated during a HIV infection. PMID: 26969150
  6. LILRA3 gene deletion was not associated with Multiple Sclerosis susceptibility and did not affect the age of disease onset, clinical subtype or disease severity. PMID: 26871720
  7. Evidence showed lack of significant association between LILRA3 deletion and multiple sclerosis pathogenesis. [meta-analysis] PMID: 26274821
  8. LILRA3 is a new susceptibility factor for systemic lupus erythematosus (SLE) and primary Sjogren's syndrome (pSS). It predisposes to certain phenotypes such as leucopenia, thrombocytopenia, autoantibody positivity and increased disease activity. PMID: 24906639
  9. The current study was conducted to investigate the association of rs103294 of LILRA3 with benign prostatic hyperplasia risk. PMID: 23615473
  10. ILT6 deletion polymorphism does not appear to be a lupus susceptibility gene in South Indian Tamils, but may behave as a genetic modifier of autoantibody phenotype by influencing the production of anti-Ro60 and anti-Ro52 autoantibodies PMID: 24899637
  11. LILRA3 is an immunostimulatory molecule, whose deficiency is associated with higher frequency of B-non-Hodgkin's lymphoma. PMID: 24363809
  12. functional LILRA3 is a novel genetic risk factor for rheumatoid arthritis (RA), especially in males. It appears to highly predispose to ACPA-positive RA and confers an increased risk of disease severity in patients with early RA. PMID: 24757135
  13. Data did not indicate any association of LILRA3 deletion with multiple sclerosis (MS) susceptibility, however, patients negative for the deletion may begin to suffer from MS significantly earlier than patients who are positive. PMID: 23238213
  14. LILRA1 and LILRA3 generally display a greater binding preference for binding to HLA-C free heavy chain, particularly following removal of beta2-microglobulin by acid treatment. PMID: 21270408
  15. These results suggest that LILRA3 may play a role in chronic inflammatory conditions such as rheumatoid arthritis. PMID: 20595277
  16. A deletion of LILRA3 gene was found in a minority of British population PMID: 12651072
  17. Six alleles characterised, of which four will encode unique peptides, one of which is likely to directly influence ligand binding. PMID: 12750859
  18. Multiple sclerosis associates with LILRA3 deletion. PMID: 19421224
  19. ILT6 deficiency may be a genetic risk factor for Sjogren's syndrome. PMID: 19790059

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Subcellular Location
Secreted.
Tissue Specificity
Detected in B-cells, and at lower levels in natural killer (NK) cells. Detected in peripheral blood monocytes and lung.
Database Links

HGNC: 6604

OMIM: 604818

KEGG: hsa:11026

STRING: 9606.ENSP00000251390

UniGene: Hs.113277

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