Recombinant Human Lumican (LUM)

1. Our data suggests that the endometrium of patients with polycystic ovary syndrome (PCOS) exhibits higher expressions of decorin and lumican than that of healthy control women in the proliferative phase of the menstrual cycle. It is then possible that this proteoglycan excess may interfere with normal endometrial hemostasis in PCOS. PMID: 28789706
2. Cancer-associated fibroblast-derived Lumican contributes to tumorigenesis and metastasis of gastric cancer PMID: 28542982
3. Lumican and versican protein expression are associated with colorectal adenoma-to-carcinoma progression PMID: 28481899
4. Lumican is downregulated in the process of scar formation and alleviates hypertrophic scarring by suppressing integrin-FAK signaling. PMID: 27693693
5. ectopic mutant lumican (L199P) may induce enlargement of axial lengths and abnormal structures and distributions of collagen fibrils in mouse sclera PMID: 27711221
6. Quantitative polymerase chain reaction for messenger RNA expression from tissue specimens revealed significantly higher expression of Biglycan (p = 0.0008) and Lumican (p = 0.01) and lower expression of Decorin (p < 0.0001) in urothelial carcinoma of bladder PMID: 28459201
7. analysis of decorin and lumican expression in fibroblasts correlated with palmoplantar collagen bundle size PMID: 26663310
8. fibroblasts stimulated with the fibrocyte-secreted inflammatory signal tumor necrosis factor-alpha secrete the small leucine-rich proteoglycan lumican. PMID: 26351669
9. This meta-analysis suggests that LUM polymorphisms are associated with the risk of high myopia. PMID: 24956166
10. The results suggest that regions within LUM is associated with ACL injury susceptibility and that genetic sequence variability within genes encoding proteoglycans may potentially modulate the ligament fibril properties. PMID: 24552666
11. meta-analysis, including 1,545 subjects from 5 studies, indicated that Chinese lumican rs3759223 C allele carriers had a decreased risk of high myopia in comparison to T allele carriers PMID: 24516061
12. These findings suggest that lumican is a potent differential diagnostic marker that distinguishes hidroacanthoma simplex from clonal-type seborrheic keratosis. PMID: 23656908
13. Lumican, decorin and dermatopontin are differentially expressed and may serve as biomarkers for metastatic and recurrent Giant cell tumor of bone PMID: 25304290
14. Lumican binds ALK5 to promote epithelium wound healing PMID: 24367547
15. Lack of Lumican expression is associated with recurrence in colon cancer. PMID: 22711178
16. This meta-analysis has suggested that there is a lack of association of the rs3759223 polymorphism with high myopia risk. PMID: 24927138
17. These findings suggest that lumican plays an important role in the pathogenesis of Bowen disease and actinic keratosis PMID: 23719483
18. lumican may be involved in cell growth and invasion through the regulation of 24 proteins expressed in pancreatic ductal adenocarcinoma. PMID: 23846574
19. This meta-analysis showed the evidence that SNP rs3759223 may affect individual susceptibility to high myopia in the Chinese population. PMID: 24061151
20. Both lumican and decorin are involved in collagen fibrillogenesis and stability. PMID: 23747391
21. Lumican gene can promote the proliferation of lung adenocarcinoma cell A549, and its mechanism may be related to increased RhoC and p-Akt protein expressions. PMID: 23643269
22. The current study did not support an association between the promoter SNPs of the LUM gene with high myopia in the Korean population. PMID: 23145541
23. Cardiac levels of lumican is increased in experimental and clinical heart failure. PMID: 23480731
24. The reduction in keratan sulfate levels and the strong correlation between chondroitin 6-sulfate and keratan sulfate levels indi-cates suppressed cartilage turnover after arthroscopic surgery. PMID: 22441960
25. lumican present in the reactive stroma surrounding prostate primary tumors plays a restrictive role on cancer progression PMID: 23399832
26. LUM in combination with other known markers, such as CRP, could be evaluated as a panel of biomarkers of POAD. PMID: 22721676
27. lumican expression and its presence in ECM has an impact on colon cancer cells motility and may modulate invasiveness of colon cancer. PMID: 22814255
28. Our results confirm that the PAX6, Lumican, and MYOC genes were not associated with high myopia in the Han Chinese in Northeastern China. PMID: 22809227
29. Lumican may be a potential acute aortic dissection (AAD)-related serum marker that may assist the diagnosis of AAD. PMID: 22228989
30. Single nucleotide polymorphisms in lumican gene are associated with systemic lupus erythematosus in the Taiwan Chinese Han population. PMID: 21885486
31. lumican and fibromodulin display different behaviors and that lumican may promote regeneration of the TMJ after degeneration and deformation induced by IL-1 beta. PMID: 22073367
32. regulates osteosarcoma cell adhesion by modulating TGFbeta2 activity PMID: 21421073
33. four polymorphisms of the LUM promoter contribute to the pathogenesis of high myopia. PMID: 20010793
34. lumican may play a key role in the generation of a new collagen network by fibroblast-like cells PMID: 20819773
35. Linkage and haplotype analyses identified 12q21.33 as a locus for posterior amorphous corneal dystrophy. However, no mutations were identified in the candidate genes (KERA, LUM, DCN, EPYC) within this region. PMID: 20357198
36. lumican protein plays important roles in the inhibition of HEK cell attachment and growth, and it might inhibit the activation of integrin pathways PMID: 20138170
37. These observations suggest that LUM gene polymorphisms contribute to the development of high myopia. PMID: 19643966
38. Data suggest that five novel genes, LUM, PDE3B, PDGF-C, NRG1 and PKD2, have great potential for predicting the efficacy of cisplatin-based chemotherapy against OSCC. PMID: 19569180
39. Expression and accumulation of lumican protein in uterine cervical cancer PMID: 11956587
40. the lumican protein synthesized by cancer cells, fibroblasts and epithelial cells with mild reactive dysplasia found adjacent to cancer cells may affect the growth of human colorectal cancer cells. PMID: 12366811
41. Lumican protein has an inhibitory effect on HEK 293 cell growth in vitro. PMID: 14720136
42. Inverse regulation in the expression of endoglin and lumican. PMID: 14996436
43. studies of lumican-transfected melanoma cells suggest that lumican is involved in the control melanoma growth and invasion and may be considered, like decorin, as an anti-tumor factor from the extracellular matrix PMID: 15149859
44. Malignant cells can actively influence the composition of the extracellular matrix through TGFbeta1 and other soluble factors. PMID: 15336555
45. No evidence that endothelial dysfunction and germline mutation of lumican and keratocan genes participate in the etiology of subepithelial corneal haze. PMID: 16760896
46. An SNP (rs3759223), which is located in the promoter region of the lumican gene, may be worth further investigation to determine its association with development of high myopia. PMID: 16902402
47. metastatic melanoma cell lines were found to express lumican mRNA and effectively secrete lumican in a proteoglycan form, characterized to be substituted mostly with keratan sulfate chains; lumican mRNA was not detected in normal melanocytes PMID: 17050378
48. In addition, no pathogenic sequence variations were found in DCN, DSPG3, LUM, PITX2 and FOXC1, which have also been implicated in corneal and anterior segment dysgenesis. PMID: 17558846
49. Lumican expression in stromal tissues plays an important role in the growth and invasion of pancreatic cancer. PMID: 17671699
50. lumican expression may be positively correlated with the differentiation and negatively correlated with the progression of osteosarcoma PMID: 18093185

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HGNC: 6724

OMIM: 600616

KEGG: hsa:4060

STRING: 9606.ENSP00000266718

UniGene: Hs.406475