Recombinant Human MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)

1. MNK1 is involved in regulating both IRES- and cap-dependent viral mRNA translation. [review] PMID: 29864503
2. High expression of MNK1 is frequent in HCC tissues, which promotes tumor proliferation and invasion, and is correlated with a poor overall survival. PMID: 29576605
3. High MNK1 expression in epithelial ovarian cancer tissues indicates poor clinical outcomes PMID: 28332091
4. these data show that NDRG1 is regulated by the oncogenic MAP kinase-interacting kinase pathway, a target for cancer therapy PMID: 28545025
5. MKNK1 polymorphism was associated with treatment response in metastatic colorectal cancer. PMID: 29045529
6. Elevated levels of p-Mnk1, p-eIF4E and p-p70S6K proteins are associated with tumor recurrence and poor prognosis in astrocytomas. Overexpression of p-eIF4E and co-expression of p-Mnk1, p-eIF4E and p-p70S6K proteins could be used as novel independent poor prognostic biomarkers for patients with astrocytomas. PMID: 27900644
7. MNK-1 controls chemokine secretion and proliferation in human airway smooth muscle cells. PMID: 27418099
8. MNK1 encodes a Ser/Thr protein kinase that interacts with extracellular signal-regulated kinase 1 and p38 mitogen-activated protein kinase, a pathway that is involved in Blood Pressure regulation through norepinephrine and angiotensin II. PMID: 27271309
9. Data show that galeterone (gal) and VNPT55 inhibit migration and invasion of prostate cancer cells, possibly by down-regulating protein expression via antagonizing the Mnk1/2-eIF4E axis. PMID: 27618366
10. data suggest a physiological role for MNK1a-Ser(353) phosphorylation in regulation of the MNK1a kinase, which correlates with increased eIF4E phosphorylation in vitro and in vivo. PMID: 27413184
11. Data suggest MNK1/MNK2 stimulate mRNA translation but only of mRNA containing both 5-prime-terminal cap and hairpin duplex; this stimulation involves up-regulation of phosphorylation/mRNA un-winding activity of eIF4E (via decreased binding to eIF4G). PMID: 26668315
12. Simultaneous targeting of androgen receptor and MNK1 by novel retinamides inhibits growth of human prostate cancer cell lines. PMID: 25605250
13. MNK1 and MNK2 inhibition ablates eIF4E1 phosphorylation and concurrently enhances eIF4E3 expression in diffuse large B-cell lymphoma. PMID: 25403230
14. Data show that interferon-gamma regulated the metabolism and mRNA translation of macrophages by targeting the kinases mTORC1 and MNK1/2, both of which converge on the selective regulator of translation initiation eukaryotic initiation factor-4E (eIF4E). PMID: 26147685
15. Data suggest that a combined pharmacologic inhibition of mTORC1 and Mnk1/2 kinases offers a therapeutic opportunity in blast crisis-chronic myeloid leukemia (BC-CML). PMID: 25527453
16. Authors show that MNK regulates SRPK via mTOR and AKT. PMID: 25187540
17. ERK1/2 signal induced MNK catalytic activity enabled enterovirus type 1 internal ribosomal entry site-mediated translation/host cell cytotoxicity through negative regulation of the Ser/Arg (SR)-rich protein kinase (SRPK). PMID: 25187541
18. These data indicate multiple myeloma cells exploit the MNK/eIF-4E pathway for selective mRNA translation without enhancing global translation and risking ER stress. PMID: 24714040
19. High expression of p-Mnk1 and p-eIF4E might be novel valuable biomarkers to predict poor prognosis of nasopharyngeal carcinoma. PMID: 24551240
20. rapalog-activated MNK1 signaling promotes glioma growth through regulation of 4EBP1; there is a molecular cross-talk between the mTORC1 and MNK1 pathways PMID: 24401275
21. These findings provide evidence for key and essential roles of the Mnk kinase pathway in the generation of the antineoplastic effects of type I IFNs in Jak2V617F-dependent myeloproliferative neoplasms. PMID: 23814052
22. MNK1, which participates in translational control in several cell types, is activated in response to physiological neutrophil agonists (LPS, TNF-alpha) in the cytoplasmic and nuclear compartments. PMID: 23401599
23. TGFbeta induces signaling involving PI3kinase-dependent Mnk-1-mediated phosphorylation of eIF4E at Ser-209 to facilitate mesangial cell hypertrophy. A role for dissociation of 4EBP-1-eIF4E complex for Mnk-1-mediated phosphorylation of eIF4E. PMID: 23359369
24. Our findings identify the MNK-eIF4E axis as a specific and critical regulator of blast crisis self-renewal, and suggest that pharmacologic inhibition of the MNK kinases may be therapeutically useful in BC chronic myeloid leukemia. PMID: 23737503
25. Chemical inhibition or siRNA knockdown of MKNK1 significantly impaired entry of genotype 1a hepatitis C virus in Huh-7 cells but had only minimal impact on viral RNA replication or cell proliferation and viability. PMID: 23365451
26. MNK1 kinase activity is required for abscission. PMID: 22454512
27. Resistance to trastuzumab was observed in tumor cells with elevated MNK1 expression, furthermore, inhibition of RSK1 restored sensitivity to resistant cells. PMID: 22249268
28. These data suggest that MNK1 regulates the phosphorylation and the subcellular distribution of hnRNP A1 and that MNK1 may play a role in the induction of senescence PMID: 22227431
29. These findings indicate that the combined inhibition of mTORC1 and MNK may prove beneficial in the treatment of cutaneous T-cell lymphoma and other malignancies. PMID: 21949767
30. Data show that PKCalpha activation elicits a cascade of orchestrated phosphorylation events that may modulate eIF4G1 structure and control interaction with the eIF4E kinase, Mnk1. PMID: 21576361
31. Findings offer insights into how MNK1 pathways control translation of cancer-related mRNAs including SMAD2, a key component of the TGF-beta signaling pathway. PMID: 21406405
32. siRNA-mediated Mnk1/2 knockdown results in partial reversal of the suppressive effects of IFNgamma on human CD34+-derived myeloid (CFU-GM) and erythroid (BFU-E) progenitors. PMID: 21149447
33. Data suggest that a proportion of breast cancers could be sensitive to inhibiting MNK kinase activity, and that the presence of phosphorylated eIF4E could provide a biomarker for the identification of responsive tumours. PMID: 20686366
34. Adenovirus 100K protein blocks cellular protein synthesis by coopting eIF4G and cap-initiation complexes and displacing or blocking binding by Mnk1, which occurs only on preassembled complexes, resulting in dephosphorylation of eIF4E. PMID: 15220445
35. Mnk1 phosphorylation by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk PMID: 15234964
36. role for MNK1 in the AML fusion protein-associated differentiation block PMID: 15516979
37. Interleukins 2 and 15 regulate Ets1 expression via ERK1/2 and MNK1 in human natural killer cells PMID: 15563472
38. Data show that Mnk1 suppression decreases eukaryotic initiation factor 4F phosphorylation without causing any change in global protein synthesis rate and cell proliferation. PMID: 15581611
39. Mnk1-mediated serine phosphorylation of Spry2 constitutes a regulatory mechanism to extend the temporal range of Spry2 activity. PMID: 16479008
40. Data show that inorganic phosphate controls cell growth by activating ERK1/2 cascades and by facilitating the translocation of Mnk1 from cytosol into nucleus through an Akt-mediated MEK pathway. PMID: 16763222
41. The activity of MKNK1 was characterized. PMID: 17590453
42. mTOR inhibition increases eIF4E phosphorylation through a PI3K-dependent and Mnk-mediated mechanism. PMID: 17724079
43. A conserved phenylalanine residue in an Mnk-specific insert is playing a key role in governing the ease with which Mnk1a can be phosphorylated. PMID: 19650764

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HGNC: 7110

OMIM: 606724

KEGG: hsa:8569

STRING: 9606.ENSP00000361014

UniGene: Hs.371594