Recombinant Human Major histocompatibility complex class I-related gene protein (MR1), partial

1. Human mucosal-associated invariant T cells possess capacity for B cell help via MR1-mediated immunoglobulins production. PMID: 28807929
2. Early endosomal TLR9 activation is important for MR1-mediated bacterial antigen presentation in B cells. PMID: 28518215
3. Polymorphism in MR1 gene is associated with susceptibility to tuberculosis. PMID: 27881839
4. we have shown that MR1-mediated MAIT cell activation is tightly regulated at several levels. Efficient MR1-mediated MAIT cell activation requires both intact bacteria to access an acidified endolysomal compartment and activation of the APC through NF-kappaB or interferon signaling pathways. PMID: 27105778
5. results suggest that high expression of MR-1 is involved in hepatocellular carcinoma progression PMID: 26823810
6. Data show that the major histocompatibility complex, class I-related protein (MR1) antigen presentation is characterized by a rapid 'off-on-off' mechanism that is strictly dependent on antigen availability. PMID: 27043408
7. endosome-mediated trafficking of MR1 allows for selective sampling of the intracellular environment PMID: 27031111
8. Studies indicate that the antigen-presenting molecules CD1 and MHC class I-related protein (MR1) display lipids and small molecules to T cells. PMID: 26388332
9. Data indicate that high expression of CD26 ia a specific markers to define major histocompatibility complex, class I-like sequence protein MR1-restricted mucosa-associated invariant T (MAIT) cells. PMID: 25752900
10. Mucosal-associated invariant T cell adaptation was a direct consequence of exposure to various exogenous MR1-restricted epitopes. PMID: 25049333
11. [review] Mucosal-associated invariant T-cell (MAIT) T-cell antigen receptor recognizes riboflavin and folic acid metabolites bound by MR1 in a conserved docking mode and thus acts like a pattern recognition receptor. PMID: 24556396
12. MR1 tetramers allow precise phenotypic characterization of human and mouse mucosal-associated invariant T cells. PMID: 24101382
13. A novel MR1B isoform probably plays a physiological role complementary to MR1A with respect to mucosal-associated invariant T cells development and/or function. PMID: 23457030
14. Human thymic MR1-restricted MAIT cells are innate pathogen-reactive effectors that adapt following thymic egress. PMID: 22692454
15. metabolites of vitamin B represent a class of antigen that are presented by MR1 for MAIT-cell immunosurveillance; as many vitamin biosynthetic pathways are unique to bacteria and yeast, data suggest that MAIT cells use these metabolites to detect microbial infection PMID: 23051753
16. Mutagenesis of MR1 showed that only two residues, which were centrally positioned and on opposing sides of the antigen-binding cleft of MR1, were essential for MAIT cell activation PMID: 22412157
17. Taken together these results strongly suggest that MR1 needs to bind proteasome-independent ligands in order to properly reach the cell surface. PMID: 21777569
18. fact that MR1 seems mainly intracellular might offer clues as to the process, given the precedence in other class I molecules PMID: 21190736
19. MR1 molecules can associate with the peptide-loading complex and can be detected at low levels at the surface of transfected cells. PMID: 12794138
20. Our results demonstrated a preferential association of MR1 with beta(2)-microglobulin in MHC class I-deficient B cell lines. PMID: 18068122
21. the presentation pathway of MR1 to MAIT cells is highly evolutionarily conserved PMID: 19416870
22. Induction of MHC class I-like antigen is associated with relapsed chronic myeloid leukemia. PMID: 19706888
23. a function for MR1 in the development of IgA producing plasma cells. PMID: 19760593

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HGNC: 4975

OMIM: 600764

KEGG: hsa:3140

STRING: 9606.ENSP00000356552

UniGene: Hs.13500