Recombinant Human Mitochondrial-processing peptidase subunit alpha (PMPCA)

Code CSB-YP606021HU
MSDS
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Source Yeast
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Code CSB-EP606021HU
MSDS
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Source E.coli
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Code CSB-EP606021HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP606021HU
MSDS
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Source Baculovirus
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Code CSB-MP606021HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
PMPCA
Uniprot No.
Alternative Names
1200002L24Rik; 4933435E07Rik; Alpha MPP; Alpha-MPP; FLJ26258; Inositol polyphosphate 5 phosphatase, 72 kD; INPP5E; KIAA0123; MGC104197; MGC93916; Mitochondrial matrix processing protease, alpha subunit; mitochondrial processing peptidase subunit alpha; Mitochondrial-processing peptidase subunit alpha; MPPA_HUMAN; P 55; P-55; Peptidase (mitochondrial processing) alpha; pmpca; RP11-413M3.1; RP23-306D20.8; SCAR2
Species
Homo sapiens (Human)
Expression Region
34-525
Target Protein Sequence
SSGGAYP NIPLSSPLPG VPKPVFATVD GQEKFETKVT TLDNGLRVAS QNKFGQFCTV GILINSGSRY EAKYLSGIAH FLEKLAFSST ARFDSKDEIL LTLEKHGGIC DCQTSRDTTM YAVSADSKGL DTVVALLADV VLQPRLTDEE VEMTRMAVQF ELEDLNLRPD PEPLLTEMIH EAAYRENTVG LHRFCPTENV AKINREVLHS YLRNYYTPDR MVLAGVGVEH EHLVDCARKY LLGVQPAWGS AEAVDIDRSV AQYTGGIAKL ERDMSNVSLG PTPIPELTHI MVGLESCSFL EEDFIPFAVL NMMMGGGGSF SAGGPGKGMF SRLYLNVLNR HHWMYNATSY HHSYEDTGLL CIHASADPRQ VREMVEIITK EFILMGGTVD TVELERAKTQ LTSMLMMNLE SRPVIFEDVG RQVLATRSRK LPHELCTLIR NVKPEDVKRV ASKMLRGKPA VAALGDLTDL PTYEHIQTAL SSKDGRLPRT YRLFR
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.
Gene References into Functions
  1. study represents the first time that defects in PMPCA and mitochondrial processing peptidase have been described in association with a disease phenotype in humans. PMID: 25808372
  2. OxLDL triggers retrograde translocation of arginase2 in aortic endothelial cells via ROCK and mitochondrial processing peptidase. PMID: 24903103
Involvement in disease
Spinocerebellar ataxia, autosomal recessive, 2 (SCAR2)
Subcellular Location
Mitochondrion matrix. Mitochondrion inner membrane.
Protein Families
Peptidase M16 family
Tissue Specificity
Ubiquitously expressed with highest expression in fetal tissues and adult brain, cerebellum and cerebellar vermis.
Database Links

HGNC: 18667

OMIM: 213200

KEGG: hsa:23203

STRING: 9606.ENSP00000360782

UniGene: Hs.495471

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