Recombinant Human Mothers against decapentaplegic homolog 6(SMAD6)

Code CSB-MP021792HU
Product Type Recombinant Protein
Size US$1848
Uniprot No. O43541
Storage Buffer Tris-based buffer,50% glycerol
Species Homo sapiens (Human)
Purity Greater than 85% as determined by SDS-PAGE.
Research Area Epigenetics and Nuclear Signaling
Source Mammalian cell
Gene Names SMAD6
Protein Names Recommended name: Mothers against decapentaplegic homolog 6 Short name= MAD homolog 6 Short name= Mothers against DPP homolog 6 Alternative name(s): SMAD family member 6 Short name= SMAD 6 Short name= Smad6 Short na
Expression Region 1-496aa
Tag Info N-terminal 10xHis-tagged and C-terminal Myc-tagged
Mol. Weight 58.5
Protein Description Full Length
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.
Involvement in disease Aortic valve disease 2 (AOVD2); Craniosynostosis 7 (CRS7)
Subcellular Location Nucleus
Protein Families Dwarfin/SMAD family
Tissue Specificity Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.
Database Links

HGNC: 6772

OMIM: 602931

KEGG: hsa:4091

STRING: 9606.ENSP00000288840

UniGene: Hs.153863

Pathway TGF-beta signaling pathway

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