Mothers against decapentaplegic homolog 6 is a protein in humans that is encoded by SMAD6 gene. Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.
The following SMAD6 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
SMAD6 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA009964 | SMAD6 Antibody |
Human,Mouse | WB, IHC, ELISA |
CSB-PA021792ZA01HU | SMAD6 Antibody |
Homo sapiens | ELISA, WB (ensure identification of antigen) |
SMAD6 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP021792MO CSB-EP021792MO CSB-BP021792MO CSB-MP021792MO CSB-EP021792MO-B |
Recombinant Mouse Mothers against decapentaplegic homolog 6 (Smad6) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SMAD6 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP021792HU CSB-EP021792HU-B |
Recombinant Human Mothers against decapentaplegic homolog 6 (SMAD6) |
Yeast In Vivo Biotinylation in E.coli |
CSB-EP021792HU | Recombinant Human Mothers against decapentaplegic homolog 6 (SMAD6) |
E.coli |
CSB-BP021792HU | Recombinant Human Mothers against decapentaplegic homolog 6 (SMAD6) |
Baculovirus |
CSB-MP021792HU | Recombinant Human Mothers against decapentaplegic homolog 6 (SMAD6) |
Mammalian cell |
SMAD6 Proteins for Gallus gallus (Chicken)
Code | Product Name | Source |
---|---|---|
CSB-YP892952CH CSB-EP892952CH CSB-BP892952CH CSB-MP892952CH CSB-EP892952CH-B |
Recombinant Chicken Mothers against decapentaplegic homolog 6 (SMAD6) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |