Product Details

Purity

Greater than 85% as determined by SDS-PAGE.

Target Names

PNMA1

Uniprot No.

Q8ND90

Research Area

others

Alternative Names

37 kDa neuronal protein; MA1; Neuron- and testis-specific protein 1; Paraneoplastic antigen Ma1; paraneoplastic neuronal antigen MA1; Pnma1; PNMA1_HUMAN

Species

Homo sapiens (Human)

Source

E.coli

Expression Region

1-353aa

Target Protein Sequence

MAMTLLEDWCRGMDVNSQRALLVWGIPVNCDEAEIEETLQAAMPQVSYRMLGRMFWREENAKAALLELTGAVDYAAIPREMPGKGGVWKVLFKPPTSDAEFLERLHLFLAREGWTVQDVARVLGFQNPTPTPGPEMPAEMLNYILDNVIQPLVESIWYKRLTLFSGRDIPGPGEETFDPWLEHTNEVLEEWQVSDVEKRRRLMESLRGPAADVIRILKSNNPAITTAECLKALEQVFGSVESSRDAQIKFLNTYQNPGEKLSAYVIRLEPLLQKVVEKGAIDKDNVNQARLEQVIAGANHSGAIRRQLWLTGAGEGPAPNLFQLLVQIREEEAKEEEEEAEATLLQLGLEGHF
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Mol. Weight

46.8 kDa

Protein Length

Full Length

Tag Info

N-terminal 10xHis-B2M-JD-tagged and C-terminal Myc-tagged

Form

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

3-7 business days

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet & COA

Please contact us to get it.

Description

The expression region of this recombinant Human PNMA1 covers amino acids 1-353. The expected molecular weight for the PNMA1 protein is calculated to be 46.8 kDa. The PNMA1 protein was expressed in e.coli. The PNMA1 coding gene included the N-terminal 10xHis-B2M-JD tag and C-terminal Myc tag, which simplifies the detection and purification processes of the recombinant PNMA1 protein in following stages of expression and purification.

Paraneoplastic antigen Ma1 (PNMA1) is a protein associated with paraneoplastic neurological disorders (PND), a group of rare conditions where the immune system mistakenly targets normal neural tissues in response to an underlying tumor, often affecting the nervous system. PNMA1 is expressed in the brain and is associated with onconeural antibodies found in patients with PND. Investigations into the molecular pathways involving PNMA1 contribute to the broader understanding of autoimmune reactions associated with cancer and may offer insights into novel treatment strategies for paraneoplastic neurological disorders.

Target Background

Gene References into Functions

PNMA2 functions as antagonist of MOAP-1 and PNMA1 through heterodimeric interaction PMID: 27003254
this study provides evidence that PNMA1 is involved in tumor growth of pancreatic carcinoma PMID: 25120759

Subcellular Location

Nucleus, nucleolus. Note=In tumor cells, it is cytoplasmic.

Protein Families

PNMA family

Tissue Specificity

Testis- and brain-specific. In some cancer patients, specifically expressed by paraneoplastic tumor cells.

Database Links

HGNC: 9158

OMIM: 604010

KEGG: hsa:9240

STRING: 9606.ENSP00000318914

UniGene: Hs.194709

Code	CSB-EP018266HUb9
Abbreviation	Recombinant Human PNMA1 protein
MSDS	MSDS Datasheet
Size	US$256
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Image	(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Recombinant Human Paraneoplastic antigen Ma1 (PNMA1)

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