Recombinant Human Probable fructose-2,6-bisphosphatase TIGAR (TIGAR)

1. Knockdown of TP53 induced glycolysis and apoptosis(TIGAR) was able to radiosensitize thioredoxin reductase-1-overexpressing gliomas by inhibiting irradiation -induced thioredoxin-1 nuclear transport. PMID: 28338004
2. findings demonstrate that the HTLV-1 latency-maintenance factor p30(II) induces the TP53-induced glycolysis and apoptosis regulator (TIGAR) and counters the oxidative stress, mitochondrial damage, and cytotoxicity caused by the viral oncoproteins Tax and HBZ PMID: 29777913
3. simultaneous mutations at all four acetylation sites completely abolish its ability to regulate metabolic targets, such as TIGAR and SLC7A11. Moreover, p53(4KR) is still capable of inducing the p53-Mdm2 feedback loop, but p53-dependent ferroptotic responses are markedly abrogated PMID: 27705786
4. High TIGAR expression was an independent predictor of poor survival and high incidence of relapse in adult patients with CN-AML. TIGAR also showed high expression in multiple human leukemia cell lines and knockdown of TIGAR activated glycolysis through PFKFB3 upregulation in human leukemia cells. PMID: 27884166
5. the upregulation of hsamiR101 in ccRCC was induced by hypoxia. Its expression deceased the protein expression of TIGAR and promoted glycolysis. This regulatory pathway may represent a novel mechanism of carcinogenesis and requires further investigation. PMID: 28138701
6. TIGAR expression in breast carcinoma cells promotes metabolic compartmentalization and tumor growth with a mitochondrial metabolic phenotype with lactate and glutamine catabolism. PMID: 27803158
7. we investigate the crosstalk between PFKFB3 and TIGAR (TP53-Induced Glycolysis and Apoptosis Regulator), a protein known to protect cells from oxidative stress. Our results show consistent TIGAR induction in HeLa cells in response to PFKFB3 knockdown PMID: 27491040
8. The study showed that miR-101 inhibited viability, induced apoptosis, pushed glucose metabolism flux from the pentose phosphate pathway into glycolysis in prostate cancer PC3 cell line by decreasing NADPH levels by throughly directly binding to 3'-UTR of TIGAR mRNA and repressing TIGAR expression. PMID: 28384067
9. This study demonstrated that a high p53 expression could be associated with the promotion of glycolysis in gastric cancer via the modulation of TIGAR expression. PMID: 27499152
10. TIGAR expression may be used as a bio-marker for detection of colorectal cancer and can be used as a target for developing therapeutics for the treatment of colorectal cancer. PMID: 26675982
11. TIGAR knockdown reduced tumor growth rate. PMID: 26691054
12. Geranylgeranoic acid induced upregulation of the TIGAR gene, which might inhibit the glycolysis in HuH-7 cells with p53 mutation. PMID: 26700591
13. TIGAR over-expression could diminish the radiosensitivity of Hs 917.T cells, and the autophagy level induced by ionizing radiation (IR) was also decreased by TIGAR transfection. PMID: 26191173
14. The Cdk5-AMT signal pathway involved in regulation of DDR by TIGAR. PMID: 25928429
15. miR-144 targeted TIGAR, inhibited proliferation, enhanced apoptosis, and increased autophagy in A549 and H460 cells PMID: 25660220
16. Results revealed that TIGAR inhibits both apoptosis and autophagy. PMID: 25085248
17. TIGAR is correlated with maximal standardized uptake value on FDG-PET and survival in non-small cell lung cancer. PMID: 24363807
18. Data show targeting MUC1-C is synergistic with bortezomib (BTZ) in suppressing p53-inducible regulator of glycolysis and apoptosis (TIGAR)-mediated regulation of reactive oxygen species levels for combining GO-203 with BTZ in BTZ resistance. PMID: 24632713
19. The kinetic properties and the structural similarity of the best substrates of TIGAR make it unlikely that TIGAR modulates cellular fructose 2,6-bisphosphate levels directly. PMID: 24423178
20. CREB regulates TIGAR expression via a CRE-binding site at the TIGAR promoter. PMID: 24036271
21. oroxylin A could increase protein and mRNA expression of TP53-induced glycolysis and apoptosis regulator (TIGAR) and synthesis of cytochrome c oxidase 2 (SCO2), which are the key metabolic modulators regulated by p53. PMID: 23612020
22. TIGAR gene expression is down regulated by oxidative stress through the mediation of reactive oxygen species PMID: 23832602
23. TIGAR regulates akt and erk phosphorylation but hase no effect on NF-kappa B activation in neocazinostatin-treated cells. PMID: 23640457
24. data provide the first evidence that targeted silencing of TIGAR induces apoptotic and autophagic cell death in HepG2 cells PMID: 23817040
25. TIGAR has roles in efficient intestinal regeneration and tumorigenesis PMID: 23726973
26. The ability of TIGAR to function as a Fru-2,6-BPase was independent of hexokinase 2 binding and mitochondrial localization, although activities can contribute to the activity of TIGAR in limiting mitochondrial ROS levels and protecting from cell death. PMID: 23185017
27. TIGAR regulates the expression of genes involved in cell-cycle progression. PMID: 22782351
28. Tp53-induced glycolysis and apoptosis regulator (TIGAR) protects glioma cells from starvation-induced cell death by up-regulating respiration and improving cellular redox homeostasis PMID: 22887998
29. SP1 can interact with the SP1-binding site within TIGAR promoter in vitro and in vivo. Conclusively, SPl is indispensable for basal activity of TIGAR promoter. PMID: 21761199
30. TIGAR abrogation provides a novel adjunctive therapeutic strategy against glial tumors by increasing radiation-induced cell impairment, thus allowing the use of lower radiotherapeutic doses. PMID: 21864926
31. These results suggest that p53 can modulate the metabolic pathways via the proteins SCO2 and TIGAR in human breast cancer. PMID: 21820150
32. Inhibition of TIGAR by c-Met results in reduction of cellular NADPH and cell death. PMID: 21057531
33. The decrease of intracellular ROS levels in response to TIGAR may also play a role in the ability of p53 to protect from the accumulation of genomic damage. PMID: 16839880
34. correlation between the recently described p53-inducible apoptosis gene TIGAR and both sensitivity to fludarabine and hENT2 expression in chronic lymphocytic leukemia cells. PMID: 18945750
35. TIGAR can modulate reactive oxygen species in response to nutrient starvation or metabolic stress, and functions to inhibit autophagy. PMID: 19713938

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HGNC: 1185

OMIM: 610775

KEGG: hsa:57103

STRING: 9606.ENSP00000179259

UniGene: Hs.504545