Code | CSB-CF842761HU |
MSDS | |
Size | $878 |
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The expression region of this recombinant Human CRBN covers amino acids 1-442. This CRBN protein is theoretically predicted to have a molecular weight of 54.5 kDa. This protein is generated in a in vitro e.coli expression system-based system. The N-terminal 6xHis tag was fused into the coding gene segment of CRBN, making it easier to detect and purify the CRBN recombinant protein in the later stages of expression and purification.
The research areas of Cereblon protein (CRBN) include cellular metabolism, immune regulation, and cancer therapy. In terms of cellular metabolism, CRBN participates in regulating protein degradation and the recycling of intracellular substances, crucial for maintaining cellular homeostasis. For immune regulation, CRBN influences the development and function of immune cells, exerting a certain impact on the normal operation of the immune system. Additionally, CRBN's role in cancer therapy is under intensive investigation, particularly showing potential significance in the treatment of hematologic malignancies like multiple myeloma. A comprehensive understanding of CRBN's functional mechanisms contributes to studying its roles in physiological and pathological processes, providing a theoretical foundation for the research of related diseases treatment.There are currently no reviews for this product.
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MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL