Recombinant Human RE1-silencing transcription factor (REST), partial

1. our study suggests that NRSF is associated with the progression of ovarian cancer, and NRSF may be a valuable early detection marker of ovarian cancer PMID: 30391650
2. genome-wide scan identified significant evidence for linkage (maximum LOD) score = 4.67 at theta = 0 for D4S398) to markers in a 5.7-cM interval on chromosome 4q12-13.1. The DFNA27 interval spans 8.85 Mb & includes at least 61 predicted and 8 known genes. PMID: 18279434
3. Results from a study on gene expression variability markers in early-stage human embryos shows that REST is a putative expression variability marker as well as a differential gene expression marker for the 3-day, 8-cell embryo stage. PMID: 26288249
4. REST rs1277306 single nucleotide polymorphism was significantly associated with cognitive aging among all subjects in an Elderly Taiwanese Population. PMID: 28142142
5. Study identified 204 REST-interacting proteins and carried out a systematic analysis of their interactome. The interaction networks of REST indicated its involvement in biological processes associated with mRNA processing, chromatin organization, and transcription. Also, it suggests a functional links between REST and TRIM28 during neuronal development. PMID: 27976729
6. Although originally aimed to capture REST activity, REST score was found to be a prognostic factor for overall survival. Further, cell lines with enhanced REST activity was found to be more sensitive to IGF1R, VEGFR and ABL inhibitors. PMID: 27698411
7. Findings have identified REST as a key regulator underlying gene repression and cellular adaptation in hypoxia. PMID: 27531581
8. these findings reveal a role for REST-associated G9a and histone H3K9 methylation in the repression of USP37 expression in medulloblastoma. Reactivation of USP37 by G9a inhibition has the potential for therapeutic applications in REST-expressing medulloblastomas PMID: 28483947
9. Low REST expression is associated with prostate cancer. PMID: 27034167
10. High REST expression is associated breast cancer. PMID: 27004407
11. Findings indicate that RE1 silencing transcriptional factor (REST) regulates its miR-124 and mir-203 gene and suggest how REST maintains oncogenic competence in glioblastoma (GBM)stem cells. These mechanisms could potentially be utilized to block REST-mediated GBM tumorigenesis. PMID: 28040710
12. findings indicate that SCYL1 does not contribute to REST turnover and thus do not support a previous study suggesting a role for SCYL1 in mediating REST degradation PMID: 28570664
13. the consequences of germline final-exon-truncating mutations in REST for organismal development and the association with the Hereditary gingival fibromatosis phenotype. PMID: 28686854
14. the mechanisms of inhibition of the small-molecule drugs 4SC-202 and SP2509 were analyzed. These drugs interfered with the viability of medulloblastoma cells, where REST/NRSF has been implicated in cancer pathogenesis. Thus, a resource for molecular REST/NRSF studies and drug development has been established. PMID: 28218430
15. Induced REST expression is capable of attenuating invasion ability of breast cancer cells. PMID: 27697091
16. Expressions of REST and RCOR1 genes may downregulate SYN1 expression in gliomas. PMID: 27685921
17. REST represses transcription of HIF-1alpha in prolonged hypoxia, thus contributing to the resolution of the HIF-1alpha response. PMID: 26647819
18. A role was determined for the NRSF-BDNF pathway in the modulation of cognitive function in patients with newly diagnosed epilepsy. PMID: 26708060
19. The splicing of REST by SRRM4 could promote the neuroendocrine phenotype in CRPC. PMID: 26071481
20. Mutations in the transcriptional repressor REST predispose to Wilms tumor. PMID: 26551668
21. a new role for REST in regulation of growth and early differentiation decisions in human embryonic stem cells. PMID: 26690059
22. TSPYL2 is an essential component of the REST/NRSF transcriptional complex for TGFbeta signaling activation PMID: 25613376
23. Cultured astrocytes gradually became refractory to reprogramming, in part by the repressor REST preventing Neurog2 from binding to the NeuroD4 promoter. PMID: 26119235
24. identified and validated a novel promoter of the MIR137 gene adjacent to miR-137 itself which can direct the expression of distinct mRNA isoforms encoding miR-137; internal promoter is regulated by repressor element-1 silencing transcription factor (REST) PMID: 25154622
25. Resveratrol via SIRT1/c-Jun downregulates REST mRNA and protein in SH-SY5Y cells. PMID: 26307266
26. Results demonstrate that REST regulates AF1q gene transcription through direct binding at -383 to -363 bp of AF1q promoter. PMID: 26341630
27. The results imply that NRSF/REST plays an important role in the survival of oral cancer cells by regulating the mTOR signaling pathway. PMID: 25524378
28. pioglitazone can inhibit proliferation and induce apoptosis of glioma cell in vitro, which may be mediated by down-regulating REST mRNA level but not by inducing alternative splicing of REST pre-mRNA PMID: 26003726
29. data support the notion of REST presence in human brain neurones and glial cells and indicate the importance of developing compounds able to restore REST-regulated transcription of neuronal genes in Huntington's disease. PMID: 24634989
30. loss of REST induces a pathogenic program that works through the type 1 insulin-like growth factor receptor/insulin receptor substrate 1 pathway. PMID: 26100015
31. The results demonstrate that there is substantial rewiring of human and mouse REST cistromes, and that REST may have human-specific roles in brain development and functions. PMID: 25990720
32. Results indicate that neuron-restrictive silencer factor plays an important role as a repressor of VGF gene regulation in neuroblastoma cells through a mechanism that is dependent on VGF-neuron-restrictive silencer element PMID: 25569790
33. TRF2-mediated counterbalance between hREST4 and REST is vital for both the generation and maintenance of neural progenitor cells PMID: 24740933
34. The STP-REST axis is a molecular driver of human triple-negative breast cancer subtype. PMID: 25453754
35. Assessment of REST-N50 and DOPEY1v2 may prove useful in diagnostic blood tests of breast cancer. REST-N50 shows a high potential as a blood biomarker for evaluating the effectiveness of therapy in the neoadjuvant setting. PMID: 25424701
36. REST variant is associated with slower hippocampal atrophy in MCI/AD. PMID: 25559091
37. REST represses PDYN expression in SH-SY5Y cells and the adult human brain and may have implications for mental health and brain/mental disorders. PMID: 25220237
38. REST is targeted to the HAR1 locus by specific DNA regulatory motifs, resulting in potent transcriptional repression. PMID: 20179156
39. the crucial regulatory function of NRSF in the heart and its importance for maintaining normal cardiac integrity. [review] PMID: 24126098
40. findings show that nSR100 plays a role in the alternative splicing of REST in small cell lung cancer (SCLC); study provides new insight into the role of nSR100 in the expression of sREST, possibly in the pathogenesis of SCLC PMID: 23928058
41. The transcriptional repressor REST binds to an RE-1 element in the STAT1 repressor region and in doing so represses transcription from the STAT1 gene regulatory region in melanoma cells lines. PMID: 23598529
42. positive interaction between REST activity and miR-124a using a luciferase-binding assay and we correlated the reciprocal expression of REST and miR-124a in our clinical cohort PMID: 24068568
43. REST levels during ageing are closely correlated with cognitive preservation and longevity; the activation state of REST may distinguish neuroprotection from neurodegeneration in the ageing brain PMID: 24670762
44. Inhibition of REST suppressed tumor growth, inhibited pericyte marker expression, and increased tumor hypoxia and apoptosis PMID: 24415532
45. Results demonstrate that REST modulates androgen receptor actions in prostate epithelia and that REST expression is negatively correlated with disease recurrence after prostatectomy. PMID: 24163104
46. REST is downregulated in advanced prostate cancer by hypoxia-induced miR-106 cluster genes. PMID: 24135225
47. SNP rs13278062, but not rs1713985 showed nominal evidence of association with AMD in a total of 1273 cases and 1652 controls of Chinese descent. PMID: 24235014
48. Our data show that DN:REST in motor cortex reversed RESTs repressive effects on target genes. PMID: 23151521
49. localization of REST protein on the p85 promoter is inhibited by MDM2 protein. PMID: 23238568
50. The role of REST in the various steps of the expression and function of the dense-core vesicle membrane is critical during development and participates in the dynamic regulation of mature cell physiology. [Review] PMID: 23651552

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HGNC: 9966

OMIM: 600571

KEGG: hsa:5978

STRING: 9606.ENSP00000311816

UniGene: Hs.307836