Recombinant Human Ribosyldihydronicotinamide dehydrogenase [quinone] (NQO2)

1. The ontogeny and population variability of human hepatic dihydronicotinamide riboside:quinone oxidoreductase (NQO2). PMID: 28346733
2. In patients with Alzheimer's disease, QR2 is overexpressed in the insular cotex. PMID: 26609153
3. NQO2-L47 is less stable towards proteolytic digestion and thermal denaturation than NQO2-F47. PMID: 24631540
4. NQO1 609C>T and NQO2 -3423G>A polymorphisms do not seem to play any significant role in susceptibility or prognosis of EC in north Indian population. PMID: 22770696
5. This first structure of a reduced quinone reductase shows that reduction of the FAD cofactor and binding of a specific inhibitor lead to global changes in NQO2 structure and is consistent with a functional role for NQO2 as a flavin redox switch. PMID: 23471972
6. both NQO1 and NQO2 modulate the efficacy of AC therapy and that NQO2 is associated with tamoxifen toxicity. PMID: 21946896
7. results indicate a role of NQO2 in the control of AKT/GSK-3beta/cyclin D1 and highlight the involvement of NQO2 in degradation of cyclin D1, as part of mechanism of chemoprevention by resveratrol PMID: 22266466
8. Results suggest that NQO2, SOD2 and SOD3 may significantly modify prognosis of breast cancer patients. PMID: 21351093
9. results suggest that the increase in hippocampal QR2 might be a cause of AD or might promote the progression of AD by causing an increase in the toxic quinone levels and consequent loss of cognitive function. PMID: 21803122
10. Selective inhibition of NQO2 over NQO1 can be attributed to the bulky aminoalkylamino substituent at the 5-position, which blocks entrance of the indolequinones into the NQO1 active site. PMID: 21718050
11. NQO2 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518
12. The NQO1 609C>T TT genotype and T allele were significantly associated with increased risk for gastric cancer (GC), whereas NQO2 -3423G>A polymorphism did not show any association with GC. PMID: 21294640
13. The first European study of the SOD2, SOD3, NQO1, and NQO2 roles in pancreatic cancer etiology did not find significant associations. PMID: 20966810
14. We observed a nominal significant association between the rs1143684 NQO2 polymorphism and the trajectory of delayed memory recall over time (p=0.029). No other associations were seen with the decline of other cognitive abilities. PMID: 18538895
15. Our findings challenge the previous assumption that the NQo2 I-16 allele is stable only when paired with another I-16 allele PMID: 19495956
16. polymorphisms associated with idiopathic Parkinson's disease PMID: 11688992
17. A significant difference was found between alcoholic patients and controls in genotype frequency at an insertion/deletion site in the promoter region of the NQO2 gene (p = 0.0014). PMID: 12960511
18. the level of NQO2 mRNA is low in AGR patients compared with the control group. Such a reduction in message suggests that the NQO2 gene may be involved in the development of clozapine-induced AGR. PMID: 14617031
19. NQO2 gene may confer susceptibility to a certain form of schizophrenia. PMID: 14639047
20. the NQO2 gene is differentially expressed by the polymorphic promoters in human cells transfected with NQO2 gene reporter constructs. Alterations in NQO2 activity might be an important factor in susceptibility to Parkinson's disease. PMID: 15451063
21. We propose that induction of NQO2 may relate to the observed increased expression of p53 that, in turn, contributes to the observed suppression of cell growth in both melanoma cell lines. PMID: 15993843
22. the nicotinamide adenine dinucleotide phosphate reduced-diaphorase interneurons in the human striatum. PMID: 16025450
23. The results combined demonstrated that Nrf2 associates with JunD, binds to ARE at nucleotide -1433, and regulates human NQO2 gene expression and induction in response to antioxidants. PMID: 16545679
24. an apparent association between an NQO2 exon 3 single-nucleotide polymorphism and lower enzymatic activity PMID: 17332305
25. The crystal structure of melatonin and 2-iodomelatonin in complex with QR2 provide a detailed description of the enzyme active site; the design of inhibitors of the enzyme might be instrumental in discriminating the role of MT1, MT2 and QR2/MT3 PMID: 18254726
26. Parkinson's disease patients were analyzed for NQO2 gene promoter polymorphisms. Three allelic variants were I-29, I-16 and D. The association of the D promoter with Parkinson's disease may be due to an increase in expression of the NQO2 gene. PMID: 18314446
27. This first structural analysis of hQR2 should enable to better understand the biological role of melatonin on this enzyme . PMID: 18502195
28. Quinone reductase 2 is a catechol quinone reductase. quinone reductase 2 could play important roles in the regulation of catecholamine oxidation processes that may be involved in the etiology of Parkinson disease. PMID: 18579530
29. nmr studies of QR2 catalytic reaction were performed; results led to conclusion that melatonin is not cleaved to form N1-acetyl-N2-formyl-5-methoxykynurenine by a catalytically active QR2, indicating melatonin is neither a substrate nor a co-substrate PMID: 18826489
30. NQO2 is a susceptibility gene for breast carcinogenesis. PMID: 19351655

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HGNC: 7856

OMIM: 160998

KEGG: hsa:4835

STRING: 9606.ENSP00000337773

UniGene: Hs.533050