Recombinant Human Superoxide dismutase [Mn], mitochondrial (SOD2)

1. Mn-SOD V allele carries a worse outcome profile after stroke, relating to nitrosative stress, inflammatory, and apoptotic response and associated with a BDNF reduction. PMID: 30150066
2. Master athletes had lower levels of miR-7, while mRNA or protein levels of SIRT3, SIRT1, SOD2, and FOXO1 levels were significantly higher in the vastus lateralis muscle of master athletes compared to muscles of age-matched controls. PMID: 30107294
3. These findings revealed the role of forkhead box M1 upregulation by manganese superoxide dismutase overexpression in maintaining lung cancer stem-like cell properties. Therefore, inhibition of forkhead box M1 upregulation by manganese superoxide dismutase overexpression may represent an effective therapeutic strategy for non-small cell lung cancer. PMID: 30111255
4. genetic association studies in population of men in Brazil: Data suggest that an SNP in SOD2 (rs4880, Val16Ala) is associated with sperm quality and male infertility in the population studied; lipid peroxidation appears higher in homozygous versus heterozygous sperm samples. PMID: 28658993
5. High SOD2 expression can be predictive of a poor clinical outcome and be clinically useful in the follow-up of metastatic Renal cell carcinoma (RCC). Therapeutics for metastatic RCCs require further improvement, such as supplementary administration of agents targeting mitochondrial SOD2 PMID: 29914010
6. Low SOD2 expression is associated with childhood obesity. PMID: 29953407
7. GLUT1 ectopic overexpression makes PCa cells more resistant to glucose deprivation and oxidative stress-induced cell death. Under glucose deprivation, GLUT1 overexpressing PCa cells sustains mitochondrial SOD2 activity, compromised after glucose removal, and significantly increases reduced glutathione (GSH) PMID: 29684818
8. Dual presence of the SOD2 Ala16Val TT variant among mother-father pairs was associated with an increased risk of pre-eclampsia when compared with the absence of the TT variant among the mother-father pairs. The SOD2 Ala16Val SNP might be involved in paternal influence on the maternal predisposition to pre-eclampsia. PMID: 29745991
9. These findings uncover a novel role for SOD2 in regulating RIG-I-like receptor -mediated antiviral innate immune signaling. PMID: 28574756
10. Diabetic ESRD carriers of CC genotype of SOD2 exon 2 had an increased risk of mortality. PMID: 27925431
11. The single nucleotide polymorphism rs4880 of the SOD2 gene was not correlated with male infertility, which, however, is to be supported by further studies with larger samples from more areas. PMID: 29658251
12. MiR-509-5p exerted tumor-suppressive effects on breast cancer progression and metastasis via targeting SOD2 in vitro. PMID: 28925482
13. review: discuss how H2O2 formation in mitochondria depends on and is controlled by MnSOD PMID: 28616679
14. SOD2 gene polymorphism may modulate biochemical responses to a 12-week swimming training. PMID: 29109056
15. Study shows an association of the polymorphism of MnSOD 47C/T in the Algerian population with type 1 diabetes without complications. PMID: 29859283
16. MnSOD is the major superoxide scavenger in mitochondria, whose activity is regulated by SIRT3-mediated deacetylation, particularly at the Lys68 site, and can be enhanced by a SIRT3 coumarin derivative. PMID: 28711502
17. Heavy alcohol drinking down-regulates ALDH2 gene expression level. Heavy smoking up-regulates SOD2 gene expression level in patients with head and neck squamous cell carcinoma. PMID: 28841898
18. This is the first report evaluating the role of SOD2 in native and T351-mutated BCR-ABL-expressing cells and in a large cohort of chronic myeloid leukemia patients. In leukemic cells silenced for SOD2 expression a specific down-regulation of the expression of PRDX2 gene was found. PMID: 29550484
19. The investigated MnSOD and Catalase polymorphisms do not predispose to the development of alcoholic Chronic Pancreatitis. PMID: 28655148
20. Allele-specific interaction between GPX1 and MnSOD affects the levels of Bcl2, Sirt3 and E-cadherin. PMID: 28587495
21. Studies suggest that both SOD3 and SOD2 superoxide dismutases are regulated by oxidative stress and redox-dependent signaling mechanisms. PMID: 29047081
22. Data confirmed that SOD2 is important in the development and prognosis of salivary adenoid cystic carcinoma (SACC); that SOD2 deregulation is related to migration and invasion in SACC; and that the SOD2-dependent production of intracellular H2O2 promotes the migration and invasion of SACC, which involves the ERK-Slug signaling pathway. PMID: 27181103
23. A model for electrostatic-mediated diffusion, and efficient binding of superoxide for catalysis is presented. PMID: 28461152
24. This study builds upon in vivo investigation examined the heroin dependency risk associated with the rs2758339 and rs5746136 polymorphisms, as well as their relationship with the SOD2 mRNA levels in normal peripheral blood cells. The findings of the present study indicated that the study polymorphisms are significantly associated with the risk of dependency to heroin but are not associated with the SOD2 expression level. PMID: 29459008
25. The results of this study revealed higher radial diffusivity in the anterior thalamic radiation among SOD2 CC genotypes compared to CT/TT genotypes. PMID: 28457881
26. Val 16Ala polymorphism in SOD2 gene contributes to individual variability in oxidative stress status and lipid profile of the blood in young wrestlers, and may modulate biochemical response to training. PMID: 28482710
27. Radiation-induced SOD2 overexpression via the chimeric C9BC promoter increased the radiosensitivity of HT-29 human colorectal cancer cells and concurrently protected normal CCD 841 CoN colorectal cells from radiation damage. PMID: 27999194
28. research demonstrated that erysipelas infection predisposition and its clinical characteristics are affected by age, sex and SNPs found in SOD1, SOD2, and catalase genes; presence of SOD2 T2734 alleles was linked to erysipelas' predisposition; T and C alleles of SOD2 T2734C individually were linked to patients with bullous and erythematous erysipelas, respectively PMID: 28512644
29. MnSOD plays an important integrative role in supporting cancer cell survival in circulation, metastasis, and doxorubicin resistance PMID: 27384484
30. SOD2 rs4880 SNP likely contributes to asparaginase-induced hepatotoxicity in adult patients with acute lymphoblastic leukemia. PMID: 27019981
31. Manganese superoxide dismutase mediates anoikis resistance and tumor metastasis in nasopharyngeal carcinoma cells. PMID: 27083052
32. Preliminary neutron diffraction analysis of human manganese superoxide dismutase has been reported. PMID: 28368283
33. Altogether, our results provide clinical evidence for the importance of SOD2 in tumor progression and mortality, and the close relationship of SOD2 and p53 in hepatocellular carcinoma. PMID: 27221200
34. SOD2 and GPX1 can interact to affect cancer risk and progression indicated that it is the net accumulation of mitochondrial H2O2 (mtH2O2) resulting from of the balance between the activities SOD2 and anti-oxidants such as GPX1 that determines whether SOD2 prevents or promotes oncogenesis. Review. PMID: 28087256
35. Low MnSOD expression is associated with Prostate Cancer. PMID: 28108513
36. High MNSOD expression is associated with Thyroid Tumors. PMID: 26970173
37. Findings suggest that the Ala16Val-MnSOD SNPs may contribute to hypercholesterolemia and higher GLU levels, increasing the risk to neurovascular events that may lead to stroke. PMID: 28552711
38. Results suggest some pharmacogenetic effects of Val16Ala-SOD2 in hypercholesterolemia patients undergoing rosuvastatin treatment. PMID: 26882122
39. he data demonstrated that linalool exhibited inhibitory effect on glioma cells through regulation of SIRT3-SOD2-ROS signaling PMID: 28567457
40. WT-MnSOD protein conserves a destabilizing amino acid at position 146 as part of a strategy to favor metal ion binding. PMID: 28704037
41. There is significant association between SOD rs4880 polymorphism and pulmonary arterial hypertension (PAH) susceptibility, and this polymorphism influenced PAH susceptibility by altering the expression of SOD2. PMID: 28272301
42. It is suggested that the MnSOD A16V polymorphism may be associated with a risk of female infertility in northern Iran. PMID: 28040123
43. Changes of Sig1R and SOD2 expression point to mitochondria as main organelle responsible for survival of tumor cells exposed to hypoxia or oxidative stress. Studied proteins are involved in intracellular response to stress related with different concentrations of oxygen. PMID: 27829319
44. These results suggest SOD2 as a newly identified gene conferring susceptibility to leprosy. PMID: 27132285
45. Results suggest that MnSOD Val(16)Ala single-nucleotide polymorphism may not contribute to lung cancer susceptibility. PMID: 23928928
46. meta-analysis suggested that SOD2 C47T polymorphism is significantly associated with an increased risk of noise-induced hearing loss in the Chinese population. PMID: 27161188
47. Study demonstrates that SOD2 rs4880, GPX1 rs1050450 and CAT rs1001179 are not associated with an increased susceptibility to epilepsy after neonatal hypoxic-ischemic encephalopathyor its drug resistance PMID: 28222320
48. The antioxidative effects of the Mediterranean diet against breast cancer risk may be enhanced by the wild-type alleles of the MnSOD or CAT SNPs among Greek-Cypriot women. PMID: 26130326
49. Lower SOD2 protein content in mononuclear cells Is associated with improved survival in chronic kidney disease patients undergoing hemodialysis therapy. PMID: 27630759
50. we identify miR-146a as a potential tumor suppressor in patients with EOC. miR-146a downregulates the expression of SOD2 and enhances ROS generation, leading to increased apoptosis, inhibition of proliferation, and enhanced sensitivity to chemotherapy. PMID: 27131313

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HGNC: 11180

OMIM: 147460

KEGG: hsa:6648

STRING: 9606.ENSP00000356022

UniGene: Hs.487046