Recombinant Human Suppressor of cytokine signaling 1(SOCS1)

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Code CSB-EP022388HU
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  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP022388HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) SOCS1.
  • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP022388HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) SOCS1.
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Product Details

Purity Greater than 90% as determined by SDS-PAGE.
Target Names SOCS1
Uniprot No. O15524
Research Area Immunology
Alternative Names CISH 1; CISH1; Cytokine inducible SH2 protein 1; JAB; JAK binding protein; JAK-binding protein; Janus kinase binding protein ; SOCS 1; SOCS-1; Socs1; SOCS1_HUMAN; SSI 1; SSI-1; SSI1; STAT induced STAT inhibitor 1; STAT-induced STAT inhibitor 1; Suppressor of cytokine signaling 1; Supressor of cytokine signalling 1; TEC interacting protein 3; Tec-interacting protein 3; TIP 3; TIP-3; TIP3
Species Homo sapiens (Human)
Source E.coli
Expression Region 1-211aa
Target Protein Sequence MVAHNQVAADNAVSTAAEPRRRPEPSSSSSSSPAAPARPRPCPAVPAPAPGDTHFRTFRSHADYRRITRASALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRESFDCLFELLEHYVAAPRRMLGAPLRQRRVRPLQELCRQRIVATVGRENLARIPLNPVLRDYLSSFPFQI
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight 27.6kDa
Protein Length Full Length
Tag Info N-terminal 6xHis-tagged
Form Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.
Gene References into Functions
  1. High SOCS1 expression is associated with higher grade breast cancer. PMID: 30453988
  2. SOCS1 gene methylation caused gene silencing of SOCS1. PMID: 29916533
  3. SOCS1 is regulated in prostate cancer cells through miR-221-5p expression. PMID: 29506516
  4. The results indicate SOCS1 plays an important role in AML and its higher expression serves as a new biomarker to risk-stratify AML patients. PMID: 28753595
  5. reveal a vital contribution of miR-155 upregulation and consequent SOCS1 downregulation to an immune response triggered via IFN-gamma in BA PMID: 28355202
  6. Guar gum fiber increases SOCS-1 expression in Caco-2 cells. PMID: 28608623
  7. overexpression of SOCS-1 prevented TNF-alpha-mediated cell oxidative stress and apoptosis in human renal tubular epithelial cells PMID: 28732559
  8. we report here that SOCS1 impacts the pattern of secreted products in cells with active p53 and is required for the expression of a selective set of p53 target genes including those involved in ferroptosis. PMID: 29081404
  9. SOCS1 attenuates migration and invasion properties of hepatocellular carcinoma cells at least partly via modulation of MET-mediated epithelial-mesenchymal transition, and controls invasive tumor growth. PMID: 29085209
  10. Our findings revealed significantly higher rates of insulin resistance, obesity and dyslipidaemia in Turkish patients with polycystic ovary syndrome compared with age-matched healthy controls, while no difference between study groups in terms of the rate of SOCS1-1478 CA/del polymorphism along with no significant relation of SOCS1-1478 CA/del polymorphism to insulin resistance and PCOS status. PMID: 28569589
  11. polymorphisms of the SOCS1 gene are associated with the risk of ischemic stroke in a northern Chinese Han population, suggesting that SOCS1 gene polymorphisms may play an important role in the pathogenesis of ischemic stroke PMID: 27216615
  12. our findings demonstrate that 5-hmC loss is an epigenetic hallmark of hepatocellular carcinoma , and miR-29a is an important epigenetic modifier, promoting HCC metastasis through TET-SOCS1-MMP9 axis silencing. The results offer a new strategy for epigenetic cancer therapy PMID: 28661477
  13. SOCS-1, SOCS-2, and SOCS-3 proteins may directly or indirectly, have important roles in development and pathogenesis of papillary thyroid cancer PMID: 28643757
  14. Report simultaneous over-expression of miR-155 and SOCS1 that may be characteristic for Sjogren's syndrome. PMID: 26620207
  15. SOCS1 inhibits epithelial IL-13 signalling, supporting its key role in regulating Th2-driven eosinophilia in severe asthma PMID: 27338192
  16. SOCS1 antagonizes epithelial-mesenchymal transition by suppressing Src activity, leading to thioredoxin expression and down-regulation of ROS levels in colon cancer cells PMID: 27613835
  17. Our findings support the tumor suppressor role of SOCS1 in PCa and suggest that attenuation of MET signaling is one of the underlying mechanisms. SOCS1 in PCa cells also appears to prevent the tumor-promoting functions of cancer-associated fibroblasts. PMID: 27779203
  18. Findings indicate that miR-21 and miR-155 promote the development of non-small cell lung carcinoma (NSCLC) in part by downregulating three tumor suppressor genes suppressor of cytokine signaling 1 protein (SOCS1), SOCS6, and PTEN. PMID: 27811366
  19. Evaluating SOCS1 and p21 protein expression in prostatectomy specimens may have a prognostic value in identifying the aggressive prostate cancer. Inverse correlation between SOCS1 expression and disease severity was observed. However, SOCS1 expression did not correlate with that of p53, MET or p21 in the whole study cohort. PMID: 28235401
  20. In this study, the authors report that JOSD1 plays an important role in regulating type-I interferon (IFN-I)-mediated antiviral activity. JOSD1 physically interacts with SOCS1, which is an essential negative regulator of many cytokines signaling, and enhances SOCS1 stability by deubiquitinating K48-linked polyubiquitination of SOCS1. PMID: 28355105
  21. Co-immunoprecipitation experiments showed that SOCS1 mutations abolished JAK3 binding, revealing a key role for SOCS1 in regulating JAK3/STAT5 signaling PMID: 27144517
  22. C/EBPbeta overexpression or knockdown did not change the levels of IL-1beta-induced SOCS1. SOCS1 regulated the levels of C/EBPbeta mRNA by ubiquitination of C/EBPbeta as well as transcriptional regulation in human chondrocytes. PMID: 27339399
  23. patients with renal graft rejection expressed lower levels of SOCS1 PMID: 27423763
  24. Inhibiting the STAT3-Mcl-1 signaling axis by ectopic SOCS1 improved radiosensitivity by inducing apoptosis and enhancing DNA damage after radiotherapy, offering a mechanistic rationale for a new esophageal squamous cell carcinoma treatment. PMID: 29042418
  25. an overview of the mechanisms underlying SOCS1 function as a tumor suppressor and discuss the emerging evidences of SOCS1 activity as an oncogene. PMID: 26811119
  26. MiRNA sponges against miR-19 or miR-155 inhibit the functions of these miRNAs and potentiate the induction of SOCS1 and p53 in mouse leukemia cells and in human myeloma cells. PMID: 26841929
  27. Mutations of CREBBP and SOCS1 are independent prognostic factors in diffuse large B cell lymphoma; SOCS1 mutations were associated with better progression-free survival. PMID: 28302137
  28. These results suggest that miR146a may regulate SOCS1/STAT3 and cytokine signalling in monocytes, directing T-cell differentiation and balancing immune clearance and immune injury during chronic viral infection. PMID: 27004559
  29. IFN-lambda signaling is regulated by SOCS1 but not by SOCS3 or USP18. PMID: 28900038
  30. This study evaluation the roles of SOCS1, the regulator of TLR9, RIG-I, and CD152 in patients with liver fibrosis/cirrhosis; the use of polymorphisms as markers for genetic risk is reported. PMID: 28762092
  31. SOCS1 rs33932899 genotype was significantly related to severe necroinflammatory activity (NIA) grade of chronic hepatitis C patients. PMID: 28704535
  32. Studies indicate that suppressors of cytokine signaling (SOCS) proteins CIS, SOCS1, and SOCS3 can be considered the third immunocheckpoint molecules since they regulate cytokine signals that control the polarization of CD4(+) T cells and the maturation of CD8(+) T cells. PMID: 28188673
  33. Results provide evidence that repression of SHP-1, SHP-2 and SOCS-1 gene expression in patient plasma cells supports the constitutive activation of the JAK/STAT3 pathway and probably leads to higher degrees of bone marrow invasion. PMID: 28369102
  34. Suppressor of cytokine signaling 1 (SOCS1) expression was upregulated in sustained virological responses (SVR) patients compared with non-SVR patients based on a multiplex reverse transcription-polymerase chain reaction analysis. Peripheral blood SOCS1 expression before treatment was not associated with SVR in hepatitis C virus (HCV) genotype 1 patients treated with pegylated IFN-alpha and ribavirin. PMID: 26786212
  35. tumor-suppressor functions of SOCS1 in the liver could be mediated, at least partly, via regulation of the expression, stability and subcellular distribution of p21 and its paradoxical oncogenic functions, namely, resistance to apoptosis and increased proliferation PMID: 26725321
  36. Suppressor Of Cytokine Signaling 1 (SOCS1) overexpression in retinal pigment epithelium cells inhibits some IFNgamma-mediated responses that lead to uveitis development. This notion raises the possibility that SOCS1 overexpression could be a novel target for treating non-infectious uveitis. PMID: 27478014
  37. nectin-4 serves as a stimulatory co-receptor for the prolactin receptor by regulating the feedback inhibition of SOCS1 in the JAK2-STAT5a signaling pathway PMID: 28258213
  38. This study showed that SOCS5 expression was significantly down-regulated. PMID: 28196747
  39. this study shows that IL-7 induces the expression of SOCS1 through the JAK/STAT-5 pathway PMID: 27423467
  40. SOCS1 silencing can inhibit proliferation and induce apoptosis of MV3 and A357 melanoma cells in vivo and in vitro by inhibiting extracellular signal-regulated kinase and janus kinase signal transduction and activators of transcription signaling pathways. PMID: 28466787
  41. SOCS1 may promote apoptosis of intestinal epithelial cells at least partly through mediating p53 signaling. PMID: 27236107
  42. The results revealed that although the expression levels of SOCS1, SOCS3 and, in particular, pSHP2, tend to decrease in the four types of astrocytomas, PIAS3 downregulation is more negatively correlated with STAT3 activation in the stepwise progress of astrocytomas and would indicate an unfavorable outcome. PMID: 28035384
  43. findings provide novel insight into how dysregulated expression of SOCS increases IL-4 responses in allergic monocytes, and this may represent a new therapeutic avenue for managing allergic disease. PMID: 27507812
  44. Overexpression of SOCS1 has a potent antitumor effect against ESCC. PMID: 28233302
  45. IL-4 signaling plays a crucial role in the regulatory functions of SOCS1 in apoptosis and inflammation in human osteoarthritic chondrocytes. These findings provide a potential therapeutic target for the clinical treatment of osteoarthritis (OA) PMID: 28373981
  46. Through promoter hypermethylation, the SOCS-1 gene was severely down-regulated in the colorectal cancer tissue samples. PMID: 27133036
  47. Reduced SOCS1 protein levels in systemic lupus erythematosus patients are correlated with enhanced STAT1 activation. PMID: 27781323
  48. These data thus suggest that overexpression of SOCS1 and SOCS3 induced by denguevirus infection leads to impairment of antiviral response through the inhibition of STAT functionality. PMID: 26709547
  49. miR-203 and miR-221 regulate SOCS1 and SOCS3 in essential thrombocythemia PMID: 26990535
  50. The HBVX gene upregulated the mRNA and protein expression levels of DNMT3A/3B, downregulated the expression of SOCS1 and increased SOCS1 gene promoter CpG island methylation. PMID: 26573490
  51. The present study confirmed that both Fas/FasL signaling and SOCS1 promoted the high glucose induced mitochondrial dysfunction and apoptosis; results implies the key regulatory role of Fas signaling and SOCS in diabetic retinopathy PMID: 26700587
  52. miR-155 levels were inversely correlated with SOCS1 mRNA expression in oral lichen planus CD4+ T cells. PMID: 26594049
  53. SOCS1 pro-oncogenic activity correlated with the down-modulation of STAT1 expression. Collectively, these results suggest that SOCS1 may work as an oncogene in CRC. PMID: 26391193
  54. SOCS1 mutation type qualifies as a single-gene prognostic biomarker in classical Hodgkin lymphoma. PMID: 26336985
  55. rs423674, or its genetic proxies, may influence MS risk by modulating SOCS1 expression in a cell-specific manner and by influencing dendritic cell function. PMID: 25623250
  56. SOCS1 promoter methylation is associated with the risk of hepatocellular carcinoma. PMID: 25853848
  57. Monocytes of juvenile idiopathic arthritis patients expressed higher transcript levels of SOCS1. PMID: 26747737
  58. SOCS1 is a target of miR-155 in oxidized low density lipoprotein-stimulated macrophages. PMID: 26159489
  59. A higher expression of SOCS1 and CLEC16A in CD4+ T cells in samples homozygous for the risk allele of CLEC16A rs12927355. PMID: 26203907
  60. detecting method and sample size also suggested that abnormal SOCS-1 promoter methylation was correlated to the risk of hepatocellular carcinoma in the majority of these subgroups PMID: 27061542
  61. SOCS1 may act as a suppressor of pulmonary fibrosis, by reducing the expression of MMPs and TIMPs. PMID: 25997387
  62. Decreased SOCS1 in PBMCs and T cells from patients with ankylosing spondylitis correlates with patient's functional ability, acute-phase reactants and serum pro-inflammatory cytokines. PMID: 26812031
  63. These results suggest that the dysregulation of SOCS1 might be associated with the pathogenesis of systemic lupus erythematosus. PMID: 25330931
  64. Data show that IFN-lambda induced a faster but shorter expression of suppressor of cytokine signaling 1 (SOCS1) which inhibited Janus kinase/signal transducer and activator of transcription (Jak/STAT) pathway and phosphorylation. PMID: 26193702
  65. Lower expression of SOCS1 is associated with response to radiation in cervical cancer. PMID: 25849377
  66. Soluble egg antigens glycans are essential for induction of enhanced SOCS1 and SHP1 levels in dendritic cells via the mannose receptor. PMID: 25897665
  67. Upregulation of SOCS1 in persistently respiratory syncytial virus-infected Hep-2 cells is related to the TLR3 signaling pathway, which could be associated with the mechanism of viral persistence. PMID: 26122642
  68. Findings indicate that SOCS1 mediates its tumor suppressor functions, at least partly, by binding to MET and interfering with downstream signaling pathways as well as by promoting the turnover of the activated MET receptor. PMID: 25728680
  69. Gal1 and gal3 regulate the inflammatory response in airway epithelial cells exposed to microbial neuraminidase by modulating the expression of SOCS1 and RIG1. PMID: 26355912
  70. By downregulating the expression of SOCS1, miR-155 wires intestinal myofibroblasts inflammatory phenotype. PMID: 25998827
  71. SOCS1 mRNA was overexpressed in multiple sclerosis patients versus controls. PMID: 25701091
  72. the mathylation of SOCS-1 gene plays an important role in the disease progression and is associated with poor survival especially among the high-risk patients. PMID: 25123164
  73. SOCS-1 -1478CA>del polymorphism does not contribute to UC susceptibility and its disease phenotype in Turkish subjects. PMID: 24985978
  74. These results suggested that the gene loss and epigenetic silencing of SOCS1 were strongly associated with hepatitis B virus-related hepatocellular carcinoma. PMID: 23941364
  75. The inflammatory response to human chorionic gonadotropin, leading to dysregulation of Il-2 expression and SOCS activation, may be factors in ovarian hyperstimulation syndrome. PMID: 25424734
  76. Forced expression of SOCS1 revealed a heretofore-unknown mechanism for regulating the cell cycle and may represent a novel therapeutic approach for the treatment of peritoneal carcinomatosis of gastric cancer. PMID: 26180928
  77. MicroRNA-19a functions as an oncogenic microRNA in non-small cell lung cancer by targeting the suppressor of cytokine signaling 1 and mediating STAT3 activation PMID: 25604748
  78. SOCS1 might contribute to immune-related liver damage in ACHBLF, and its aberrant methylation may be a key event for the prognosis of ACHBLF. PMID: 25045829
  79. protein levels are increased in bronchial epithelium from asthmatic patients PMID: 25630941
  80. discuss the SOCS1-dependent regulation of MET signaling as an important mechanism underlying the tumor suppressor role of SOCS1 that is relevant not only to hepatocellular carcinoma but also to other types of cancers. PMID: 23944359
  81. alveolar macrophages can secrete SOCS1 and -3 in exosomes and microparticles, respectively, for uptake by alveolar epithelial cells and subsequent inhibition of STAT activation. PMID: 25847945
  82. Suppressor of cytokine signaling 1 is a positive regulator of TGF-beta-induced prostaglandin production in human follicular dendritic cell-like cells. PMID: 25825445
  83. SOCS1 interference reduced the proliferation ability of Mel526 human melanoma cells and increased their sensitivity to IFN-gamma. PMID: 25322862
  84. Low expression of SOCS-1 is associated with gastric cancer. PMID: 25261987
  85. IL-6-mediated upregulation of SOCS1 is the mechanism by which umbilical cord mesenchymal stem cells regulate dendritic cell tolerogenic phenotypes. PMID: 24730420
  86. transcription level is higher in survivors than non-survivors both in pre- and post-treatment acute-on-chronic hepatitis B liver failure patients PMID: 24727541
  87. HIV gp120-induced IL-23 upregulated suppressor of cytokine signaling 1 (SOCS1) protein in T cells, which inhibited IFN-gamma production. PMID: 25234720
  88. SOCS-1 mRNA can be detected in PBMC, and it is down-regulated in IPF patients. PMID: 24890164
  89. SOCS1 genetic polymorphisms are associated with chronic hepatitis B virus infection. PMID: 24768946
  90. SOCS1 expression decreases with the aggressiveness of colorectal cancer. PMID: 24726456
  91. this proof-of-principle study suggested that methylation of SOCS-1 can be detected in serum of HLA-B27+ AS patients but not in B27+ controls. The pathogenic potential of SOCS-1 methylation in AS deserves further investigation. PMID: 24532142
  92. The analyzed region in the SOCS1 was found in a predominant unmethylated state in both groups, as it was expected for CpG islands in normal cells, allowing gene transcription in aggressive periodontitis. PMID: 24769218
  93. A differential expression of both SOCS1 and SOCS3 was observed between PBMCs and neutrophils in patients with Behcet's disease. PMID: 25207681
  94. The four studied polymorphisms of the SOCS1 gene play an important role as susceptibility markers for developing acute coronary syndrome. PMID: 24997329
  95. Respiratory syncytial virus NS1 upregulates SOCS1 expression in a RIG-I- and TLR3-independent pathway, to inhibit STAT2 phosphorylation. PMID: 24480984
  96. Our results show that SOCS1 is induced by IL1-beta in osteoarthritis chondrocytes PMID: 24238405
  97. Suggest that the helicase HAGE has a key role in the resistance of ABCB5+ malignant melanoma stem cells to IFNalpha treatment by promoting SOCS1 expression. PMID: 24525737
  98. This study is the first to provide evidence that SOCS1 is involved in the regulation of neurogenesis. PMID: 24557021
  99. The transcription factors GLI1 and GLI2 activate the SOCS1 promoter, which contains five putative GLI binding sites, and GLI2 binding to the promoter was shown by chromatin immunoprecipitation. PMID: 24058673
  100. In conclusion, miR-221 could accentuate interferon's anti-hepatitis C virus effect by targeting SOCS1 and SOCS3. PMID: 25019494

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Subcellular Location Nucleus, Cytoplasmic vesicle
Protein Families SOCS1 family
Tissue Specificity Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes.
Database Links

HGNC: 19383

OMIM: 603597

KEGG: hsa:8651

STRING: 9606.ENSP00000329418

UniGene: Hs.50640

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