Suppressor of cytokine signaling 1 is a protein in humans that is encoded by SOCS1 gene. SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2.
The following SOCS1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
SOCS1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA022388LB01HU | SOCS1 Antibody, HRP conjugated |
Human | ELISA |
CSB-PA022388LA01HU | SOCS1 Antibody |
Human | ELISA, IHC |
CSB-PA004129 | SOCS1 Antibody |
Human,Mouse,Rat | WB, ELISA |
CSB-PA634030 | SOCS1 Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA277236 | SOCS1 Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
SOCS1 Antibodies for Mus musculus (Mouse)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA022388ZA01MO | Socs1 Antibody |
Mus musculus | ELISA, WB (ensure identification of antigen) |
SOCS1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-EP022388HU | Recombinant Human Suppressor of cytokine signaling 1 (SOCS1) |
E.coli |
CSB-YP022388HU | Recombinant Human Suppressor of cytokine signaling 1 (SOCS1) |
Yeast |
CSB-BP022388HU CSB-MP022388HU CSB-EP022388HU-B |
Recombinant Human Suppressor of cytokine signaling 1 (SOCS1) |
Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SOCS1 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP022388MO CSB-BP022388MO CSB-MP022388MO CSB-EP022388MO-B |
Recombinant Mouse Suppressor of cytokine signaling 1 (Socs1) |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP022388MO | Recombinant Mouse Suppressor of cytokine signaling 1 (Socs1) |
E.coli |
SOCS1 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP022388RA CSB-EP022388RA CSB-BP022388RA CSB-MP022388RA CSB-EP022388RA-B |
Recombinant Rat Suppressor of cytokine signaling 1 (Socs1) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SOCS1 ELISA Kit for Mus musculus (Mouse)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E17346m | Mouse suppressors of cytokine signaling 1(SOCS-1)ELISA Kit |
serum, plasma, tissue homogenates | 15.6 pg/mL |