Product Details

Purity

Greater than 85% as determined by SDS-PAGE.

Target Names

TMEFF1

Uniprot No.

Q8IYR6

Research Area

others

Alternative Names

C9orf2; C9orf3 TMEFF1; C9orf30 TMEFF1; C9orf30 TMEFF1 fusion protein; Cancer/testis antigen family 120 member 1; CT120.1; H 7365; H7365; MSANTD3-TMEFF1 readthrough; TEFF 1; TEFF1; TEFF1_HUMAN; TMEFF 1; TMEFF1; Tomoregulin-1; Tomoregulin-1 precursor; TR 1; TR-1; TR1; Transmembrane protein with EGF like and two follistatin like domains 1; Transmembrane protein with EGF-like and one follistatin-like domain

Species

Homo sapiens (Human)

Source

E.coli

Expression Region

40-330aa

Target Protein Sequence

SNQPPGGGGGSGGDCPGGKGKSINCSELNVRESDVRVCDESSCKYGGVCKEDGDGLKCACQFQCHTNYIPVCGSNGDTYQNECFLRRAACKHQKEITVIARGPCYSDNGSGSGEGEEEGSGAEVHRKHSKCGPCKYKAECDEDAENVGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCIKQEQIDIRHLGHCTDTDDTSLLGKKDDGLQYRPDVKDASDQREDVYIGNHMPCPENLNGYCIHGKCEFIYSTQKASCRCESGYTGQHCEKTDFSILYVVPSRQKLTHV
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Mol. Weight

38.5 kDa

Protein Length

Partial

Tag Info

N-terminal 10xHis-tagged and C-terminal Myc-tagged

Form

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

3-7 business days

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet & COA

Please contact us to get it.

Description

Amino acids 40-330 form the expressed segment for recombinant Human TMEFF1. This TMEFF1 protein is theoretically predicted to have a molecular weight of 38.5 kDa. This protein is generated in a e.coli-based system. Fusion of the N-terminal 10xHis tag and C-terminal Myc tag into the TMEFF1 encoding gene fragment was conducted, allowing for easier detection and purification of the TMEFF1 protein in subsequent stages.

Human tomoregulin-1 (TMEFF1) functions as a transmembrane protein involved in cellular signaling and modulation of cell growth. The primary function of TMEFF1 includes influencing intracellular pathways related to cell proliferation and differentiation. Investigating TMEFF1 provides insights into cellular processes, cancer biology, and neurodevelopmental mechanisms. In cancer research, TMEFF1's aberrant expression is associated with various cancers, making it a potential biomarker and therapeutic target. In neurobiology, TMEFF1 is implicated in neuronal differentiation and development.

Target Background

Function

May inhibit NODAL and BMP signaling during neural patterning. May be a tumor suppressor in brain cancers.

Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Protein Families

Tomoregulin family

Tissue Specificity

Expressed predominantly in brain, and at lower levels in heart, placenta and skeletal muscle. Down-regulated in brain tumors as compared to control brain tissues.

Database Links

HGNC: 11866

OMIM: 603421

KEGG: hsa:100526694

STRING: 9606.ENSP00000364013

UniGene: Hs.598100

Code	CSB-EP818263HU
Abbreviation	Recombinant Human TMEFF1 protein, partial
MSDS	MSDS Datasheet
Size	$306
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Image	(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Recombinant Human Tomoregulin-1 (TMEFF1), partial

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