Recombinant Human Vasopressin-neurophysin 2-copeptin (AVP ARVP VP)

1. Serum copeptin concentrations did not vary between the pregnancies complicated by intrahepatic cholestasis of pregnancy and the healthy pregnancy control group. PMID: 28552021
2. Copeptin appears to be an independent predictor of long-term mortality in a selected population of patients suspected for an acute coronary syndrome (ACS). In addition, copeptin may be considered as an early marker for the identification of patients at higher risk of the development of heart failure at long term in patients with acute chest pain. PMID: 29619130
3. Increased levels of NT-proBNP seems to be a better biomarker of multidrug antihypertensive therapy requirement than CT-proAVP. PMID: 29190613
4. High AVP expression is associated with gestational diabetes insipidus. PMID: 29378555
5. Plasma concentration of copetin demonstrated associations with stroke occurrence in a West African cohort but was not associated with stroke severity or mortality. PMID: 29074065
6. Data suggest that corticotrophin-releasing hormone (CRH) is able to stimulate copeptin release in healthy controls suggesting direct interaction of CRH/CRH-receptor signaling and vasopressin; these interactions appear to be altered in patients with pituitary disease; copeptin may be serum biomarker of altered CRH/CRH-receptor signaling in pituitary diseases. PMID: 28795329
7. copeptin might have a potential role in the pathogenesis of restless legs syndrome and be a biomarker for this disease. PMID: 29148047
8. Serum copeptin is a strong prognostic marker in both chronic obstructive pulmonary disease and acute heart failure. PMID: 29100503
9. Hypothalamic suprachiasmatic nucleus -AVP-ir showed a significant negative correlation with age in the control group and in the male, but not in the female depression group. PMID: 28608287
10. elevated plasma copeptin level is associated with an increased risk of heart failure (HF) and all-cause mortality in patients with HF. PMID: 28244638
11. Resistin, but not copeptin levels are higher in acute ischemic stroke patients early after the stroke onset, than in age and gender matched stroke-free controls. Moreover, higher copeptin concentrations are predictive of poor short term functional outcome after ischemic stroke PMID: 28845746
12. Cord blood copeptin concentration does not seem to be a promising marker of acute kidney injury in asphyxiated neonates. PMID: 27590891
13. Elevated cord blood copeptin has high potential to become a routinely used biomarker for acute birth asphyxia and neonatal distress. PMID: 28351056
14. Copeptin seems to be a promising independent biomarker for predicting the functional outcome and all-cause mortality within 3 months or 1 year after acute ischemic stroke--{REVIEW} PMID: 27904159
15. Data suggest that men with type 1 diabetes and albuminuria had greater serum copeptin concentrations than men with normo-albuminuria. PMID: 27979439
16. associated with significantly greater annual decline of glomerular filtration rate PMID: 27347674
17. Copeptin levels are elevated in cerebral infarction, intracranial hemorrhage and subarachnoid hemorrhage but cannot be used in their differential diagnosis. PMID: 28164562
18. High circulating copeptin and decline in glomerular filtration rate indicate greater risk of new onset chronic kidney disease. (Review) PMID: 28714397
19. MR-proADM but not copeptin was significantly associated with prognosis of COPD exacerbations at 30 days. PMID: 28408815
20. vasopressin and the glycopeptide - mediate physiological aggregation of the wild-type hormone precursor into secretory granules and the pathological fibrillar aggregation of disease mutants in the endoplasmic reticulum. PMID: 28122547
21. The inability to clear misfolded proAVP with highly reactive cysteine thiols in the absence of Sel1L-Hrd1 ERAD causes proAVP to accumulate and participate in inappropriate intermolecular disulfide-bonded aggregates, promoted by the enzymatic activity of protein disulfide isomerase (PDI). PMID: 28920920
22. High copeptin expression is associated with hypoxic-ischemic encephalopathy. PMID: 28931055
23. Copeptin and osmolality were unaffected by sitagliptin treatment in type 2 diabetics with acute coronary syndrome. PMID: 27190088
24. Copeptin levels are highest among acute myocardial infarction patients with glucose disturbances and predict an adverse prognosis in unadjusted analyses. PMID: 28118730
25. high serum copeptin level is associated with disease severity and progression in IgA nephropathy. PMID: 28057871
26. Copeptin was independently associated with an increased risk of incident stroke and CVD mortality in men with diabetes, but not in men without diabetes. PMID: 27312697
27. Copeptin level at admission predicts final infarct size in STEMI patients. PMID: 27344134
28. Copeptin (>/=9.6 pmol/L) was associated with significantly higher rates of myocardial injury and improved risk stratification in patients scheduled for noncardiac surgery with nonelevated preoperative troponin. PMID: 27870734
29. It seems reasonable to indicate genetic testing of patients with isolated neurohypophyseal diabetes insipidus occurring during childhood or adolescence without a family history and without any identifiable cause as mutations of the AVP gene have been previously detected in children, who were thought to have idiopathic disease PMID: 27539621
30. High plasma copeptin was associated with reduced insulin sensitivity and an increased risk for IFG/T2DM diabetes in this community-based cohort. Moreover, in men, allelic associations support a causal role for vasopressin in these disorders. PMID: 27049477
31. Copeptin was elevated in, and independently predicted prognosis in Heart Failure PMID: 27523461
32. Baseline measurements of Copeptin in patients undergoing renal sympathetic denervation (RDN) for resistant hypertension have no predictive value for response to RDN. PMID: 27775435
33. Copeptin/UNa ratio may be used as a potential biomarker of Syndrome of Inappropriate Antidiuretic Hormone (SIADH in patients with tick-borne encephalitis (TBE) . Copeptin concentration is significantly higher in patients with TBE than in viral meningitis of other origin, especially in patients aged 18-34 and >49 years old. Copeptin does not differentiate TBE of mild and severe course. PMID: 27882774
34. Copeptin and troponin T measurement could potentially improve the prehospital diagnostic and prognostic classification of patients with a suspected AMI. PMID: 27903076
35. The early polyuria in recessive central diabetes insipidus contrasts with the delayed presentation in patients with monoallelic AVP mutations. PMID: 26565711
36. Heart Failure is a complex syndrome with the differential integration of stimulatory and inhibitory inputs to the AVP/copeptin secretory system. PMID: 27396431
37. copeptin may be a good biomarker for metabolic syndrome. PMID: 27928437
38. The present study reports the genetic, clinical and biochemical characteristics of patients with Familial neurohypophyseal diabetes insipidus caused by five novel mutations in AVP. PMID: 27513365
39. The combination of a clinical model with copeptin and NTproBNP, which are available in the Emergency Department, is able to prognose early mortality in patients with an episode of Acute Heart Failure. PMID: 28069402
40. High Serum copeptin levels are associated with respiratory infections. PMID: 27171391
41. A high serum copeptin concentration predicts transplant-free survival, particularly at 6 months, independently of liver-specific scoring systems in a heterogeneous population of hospitalized cirrhotic patients. PMID: 26502363
42. A direct release of copeptin is not detectable from the human heart in acute myocardial infarction. PMID: 26864512
43. plasma copeptin levels can be regarded for promising marker of severity of acute pulmonary embolism and show potential in risk stratification of these patients PMID: 26438275
44. AVP gene mutation is associated with neurohypophyseal diabetes insipidus. PMID: 26208472
45. Serum copeptin was found to be increasing significantly in cases of myocardial ischemia detected by myocardial perfusion scintigraphy. PMID: 26100831
46. Serum copeptin is elevated in patients with acute pulmonary embolism. PMID: 26711465
47. There was no significant difference in serum copeptin between patients with vasovagal syncope, epilepsy, and controls. PMID: 26641207
48. Data from a population in Sweden suggest association between elevated copeptin plasma levels at time of diagnosis of type 2 diabetes and later development (within 10-12 years) of renal insufficiency and progression to chronic kidney disease stage 3. PMID: 26321369
49. This study evaluated the relationships among copeptin, ischemia-modified albumin (IMA), and extent of myocardial injury in patients with acute carbon monoxide poisoning. PMID: 26345979
50. Low serum sodium was associated with an increased risk of cardiovascular and all-cause mortality in type 2 diabetes, but association was not explained by copeptin. PMID: 26201002

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HGNC: 894

OMIM: 125700

KEGG: hsa:551

STRING: 9606.ENSP00000369647

UniGene: Hs.89648