Recombinant Mouse Adenylate cyclase type 8(Adcy8) ,partial

Code CSB-YP001344MO
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Source Yeast
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Code CSB-EP001344MO
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Source E.coli
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Code CSB-EP001344MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP001344MO
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Source Baculovirus
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Code CSB-MP001344MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Adcy8
Uniprot No. P97490
Alternative Names Adcy8Adenylate cyclase type 8; EC 4.6.1.1; ATP pyrophosphate-lyase 8; Adenylate cyclase type VIII; Adenylyl cyclase 8; Ca(2+)/calmodulin-activated adenylyl cyclase
Species Mus musculus (Mouse)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity).
Gene References into Functions
  1. Genetic deletion of AC8 (adenylyl cyclase 8) but not AC1 abolished long-lasting anxiety. PMID: 27234425
  2. Dysregulation of a survival pathway in adenylyl cyclase 1 and 8 knockout mice was identified following early-life ethanol exposure. PMID: 26992697
  3. Study shows that AC8 is involved in epileptogenesis, and may serve as a potential target for the treatment of epilepsy PMID: 26656781
  4. ADCY8 is required for the physiological activation of glucose-induced signalling pathways in beta cells, for glucose tolerance and for hypothalamic adaptation to a high-fat diet via regulation of islet insulin secretion. PMID: 25403481
  5. these results support a complex role of cAMP signaling pathways confirming the involvement of AC8 in the modulation of stress responses. PMID: 20638449
  6. ACVIII gene is regulated by CREB in vitro and in vivo and this regulation may contribute to CREB-dependent neural plasticity PMID: 12405989
  7. AC8 accumulates in puncta of dendrites and axons in hippocampal neurons and localizes with synaptic marker proteins indicating synaptic and nonsynaptic cAMP signals generated by different Ca2+-stimulated adenylyl cyclases are required for mossy fiber LTP PMID: 14585998
  8. AC8 expression is initially restricted to the epithalamus, the hypothalamus, the superior colliculus, the cerebellar anlage the proliferative zone of the rhombic lip, and the spinal cord. PMID: 15844169
  9. AC8 protein levels were abundant during development, with diffuse and increasing expression in the hippocampus that intensified in the CA1/CA2 region by adulthood. in the presynaptic active zone and extrasynaptic fractions. PMID: 17335981
  10. data suggest that AC1/AC8 are crucial activators of cell survival signaling pathways acutely following ethanol exposure and represent molecular factors that may directly modulate the severity of symptoms associated with Fetal Alcohol Syndrome PMID: 18992344

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Subcellular Location Membrane, Multi-pass membrane protein
Protein Families Adenylyl cyclase class-4/guanylyl cyclase family
Database Links

KEGG: mmu:11514

STRING: 10090.ENSMUSP00000023007

UniGene: Mm.1425

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