Recombinant Mouse CD226 antigen (Cd226), partial

1. DNAM-1 (CD226) has been associated with specific inhibitory receptors, suggesting that it might be functionally involved in natural killer cell education. The present study shows that DNAM-1 function is associated with natural killer cell education but is not necessary to reach nor maintain the educated state. The authors propose a model in which natural killer cell education prevents or delays downregulation of DNAM-1. PMID: 28561023
2. Results indicate that low-grade inflammation coupled with elevated blood glucose increases CD226 expression, resulting in decreased endothelial cell glucose uptake in T2DM. PMID: 26910838
3. Data show that the severity experimental autoimmune encephalomyelitis (EAE) were reduced and the serum IL-10 expression levels were increased in CD226 knockout mice than that in control mice when both received EAE induction. PMID: 26942885
4. Blocking CD226 inhibited NK cell-mediated cytotoxicity of the GM-CSF-stimulated Flt3 ligand conventional dendritic cells. The CD226(+)NKG2A(-) subset of NK cells was better at targeting GM-CSF-stimulated Flt3 ligand conventional dendritic cells. CD155, a known ligand for CD226, could also act as an inhibitor of NK cell-mediated lysis, as dendritic cells lacking CD155 were more sensitive to NK cell-mediated lysis. PMID: 27034402
5. inflammatory monocytes, together with NK cells, are essential in the early control of CMV through the DNAM-1-PVR pathway. PMID: 27503073
6. Data show that CD155 protein/CD226 antigen mainly mediates the interaction between NK cells and leukemic cells in acute myeloid leukemia. To investigate the interaction between leukemic cells PMID: 26588911
7. absence of either CD155 or CD226 in BALB/c mice causes a profound shift in the Natural Killer T-Cells subtype composition in thymus, expanding the frequency and numbers of iNKT1 cells at the expense of iNKT2 cells, as well as iNKT17 cells. PMID: 26689152
8. our results suggest a limited role for DNAM-1 in solid allograft rejection. Blocking DNAM-1 is not sufficient to prevent allograft rejection and might be relevant only in combination with additional inhibitors of costimulation. PMID: 26840537
9. we propose that expression of DNAM-1 on inflammatory monocytes are evolutionally conserved and act as an adhesion molecule on blood inflammatory monocytes. PMID: 26675069
10. Data indicate that DNAM-1 (CD226) signaling was required to enhance cytotoxicity. PMID: 26552706
11. Regulatory T cells derived from Cd226-deficient mice showed similarly reduced inhibitory activity, eventually resulting in an exacerbated disease course of experimental autoimmune encephalomyelitis. PMID: 26359290
12. CD226 limits spontaneous multiple myeloma development in Vk*MYC transgenic mice. This is mediated both by NK and CD8+ T cells through perforin and IFN-gamma pathways. It also is needed for cyclophosphamide and bortezomib treatment effectiveness. PMID: 25893601
13. Findings suggest that TIGIT is a key checkpoint inhibitor of chronic antiviral and antitumor responses through impairing CD226 function when disrupting its homodimerization. PMID: 25465800
14. This synapse defect may explain why DNAM-1-deficient mice cannot clear tumors in vivo. PMID: 24337740
15. cooperative signaling through DNAM-1 and Ly49H are required for NK cell-mediated host defense against MCMV infection PMID: 24440149
16. An inactivation gene strategy showed that DNAM-1 exerts profibrotic effects by controlling T cell activation and cytokine release. PMID: 23161903
17. These observations establish a firm link between the functions of CD155 and CD226 in several T cell differentiation steps. PMID: 22429743
18. High DNAM-1 expression is associated with graft-versus-host disease in leukemia. PMID: 23430112
19. DNAM-1 -/- CD8 T cells had significant reductions in TNF-alpha and IL-2 that were associated on adoptive transfer with the inability to terminate the persistent Arenaviridae infection. PMID: 22579352
20. Intranodal interaction with dendritic cells dynamically regulates surface expression of the co-stimulatory receptor CD226 protein on murine T cells. PMID: 21937446
21. Activated CD226-positive natural killer (NK)cells mediate kidney injury in MRL/lpr mice; kidney-infiltrating NK cells display an activated phenotype and a marked ability to produce cytotoxic granules. PMID: 21296979
22. mice that received allogeneic splenocytes deficient in DNAX accessory molecule-1 (DNAM-1) had significantly milder GVHD and lower mortality than those that received allogeneic WT splenocytes PMID: 20937876
23. CD155 appeared to be a key ligand recognized by DNAM-1 in NK cell-mediated suppression of metastases PMID: 20008292
24. We demonstrated that ligand binding of murine DNAM-1 induced a costimulatory signal in antigen-specific CD8+ T cells. PMID: 15752754
25. CD226 is a costimulatory molecule that plays an important role in activation and effector functions of T helper type 1 (Th1) cells. PMID: 16034094
26. DNAM-1 ligands stimulate innate immunity by in dendritic and natural killer cells, which efficiently prime cell-mediated tumor-specific immunity. PMID: 16249389
27. Th1 cells retain up regulate the expansion of CD226 PMID: 16547212
28. serine phosphorylation of DNAM-1 primarily induces physical association of DNAM-1 with LFA-1, which then takes DNAM-1 into lipid raft compartment. PMID: 16636013
29. These results suggest that, at least in part, the binding of PVR with DNAM-1 negatively regulates osteoclast formation. PMID: 17286202
30. During postnatal development, CD226 could not be detected at its adult locations until postnatal day 12; however, it was temporally expressed in the somata of neighboring or distant nuclei associated with its adult location. PMID: 18793698
31. These results indicate that DNAM-1 plays an important role in immune surveillance of tumor development. PMID: 19029379
32. Results suggest that DNAM-1 serves to extend the range of target cells that can activate CD8 T cell and NK cells, and may be essential for immunosurveillance against tumors and/or viruses that evade recognition by other activating or accessory molecules. PMID: 19029380
33. CD226 adheres to CD155 via its first domain; blocking the CD226/CD155 interaction prevents NK-driven killing of immature DC PMID: 19380711
34. CD226 is an antiapoptotic molecule that may play an important role in regulating thymus cellularity during murine development. PMID: 19380793

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KEGG: mmu:225825

STRING: 10090.ENSMUSP00000043551

UniGene: Mm.139293