Recombinant Mouse DNA excision repair protein ERCC-1 (Ercc1)

1. chronic treatment of Ercc1(-/) mice with the mitochondrial-targeted radical scavenger XJB-5-131 attenuated oxidative DNA damage, senescence and age-related pathology. PMID: 29747066
2. Dietary tryptophan restriction increased microbial diversity and made the gut microbiota composition of old Ercc1(-/Delta7) mice more similar to that of young WT mice. PMID: 27418353
3. we quantified the frequency of aneuploidy of three autosomes in the cerebral cortex and cerebellum of adult and developing brain of Bub1b(H/H) mice, which have a faulty mitotic checkpoint, and Ercc1(-/Delta7) mice, defective in nucleotide excision repair and inter-strand crosslink repair. we found that Bub1b(H/H), but not Ercc1(-/Delta7) mice, have a significantly higher frequency of aneuploid nuclei relative to wild-t... PMID: 26681803
4. these results establish USP45 as a new regulator of XPF-ERCC1 crucial for efficient DNA repair PMID: 25538220
5. ERCC1 is critical for protecting chondrocytes from catabolic stress and is associated with the pathophysiology of osteoarthritis. PMID: 24964749
6. SLX4 is a tumor suppressor, which activates XPF-ERCC1 nuclease specificity in DNA crosslink repair. PMID: 24726326
7. ERCC1 is essential for melanoma growth and resistance to cisplatin. PMID: 21722328
8. Smad4 loss-associated Snail reduction compromises Ercc1-mediated DNA repair, contributing to increased UV-induced skin carcinogenesis. PMID: 23648546
9. analysis of accelerated loss of hearing and vision in the DNA-repair deficient Ercc1(delta/-) mouse PMID: 22257940
10. This study demonistrated that the ERCC1 deficiency-associated downregulation of the cholesterol biosynthesis pathway is at least in part due to lowered expression of its master transcription factor SREBF2 PMID: 22245387
11. These results show that mice, in which the defect in DNA repair is limited to neurons, develop an age-related impairment of context-dependent fear learning. PMID: 21880916
12. we have identified a novel skin-specific Ercc1 transcript in mice that originates from a promoter approximately 400 bp upstream of the normal promoter, rather than from more distant potential transcriptional start sites. PMID: 20407824
13. Ercc1(Delta/-) mice develop widespread astrocytosis and microgliosis, and motor neuron loss and denervation of skeletal muscle fibers. PMID: 20602234
14. Performed metabolic profiling of serum and urine of the ERCC1(d/-) mouse, which has a modified ERCC1 gene, in comparison to wild type ERCC1 mice and in relation to aging by (1)H NMR spectroscopy. PMID: 20507129
15. Results suggest that the repair functions of Ercc1 are required in both male and female germ cells at all stages of their maturation. PMID: 12466203
16. ERCC1 is not required for immunoglobulin class switching PMID: 12713813
17. Data reveal an unanticipated involvement of the ERCC1/XPF NER endonuclease in the regulation of telomere integrity. PMID: 14690602
18. mitomycin C triggered sister chromatid exchanges in wild-type cells but chromatid fusions in Ercc1(-/-) and Xpf mutant cells, indicating that in their absence, repair of double-strand breaks(DSBs)is prevented. PMID: 15199134
19. ERCC1 might be involved in processing or repair of DNA lesions in S regions during CSR. PMID: 15280420
20. This alternate transcript is ubiquitous in human tissues and cancer cell lines, but is absent in mouse and thus does not appear to be cancer related. PMID: 15688021
21. proliferative reserves of hematopoietic progenitors and stress erythropoiesis were significantly reduced in Ercc1-/- mice compared to age-matched controls PMID: 15692571
22. In a skin-specific Ercc1 knockout, hairless mice were hypersensitive to UV irradiation and developed fasat-growing skin tumors early in actinic progression. Ercc1 has a key role in protecting against UV-induced skin cancer. PMID: 16682947
23. no elevation in the levels of reactive oxygen species, or of malondialdehyde DNA adducts, a product of oxidative DNA damage, were found in Ercc1-deficient liver and no elevated levels of genes involved in the oxidative damage response were seen PMID: 17126084
24. While some aspects of the Ercc1-deficient phenotype are indicative of functional neurodegeneration, we obtained no structural evidence for this. PMID: 18221731
25. These data support the conclusion that, as in yeast, ERCC1-XPF facilitates double-strand breaks repair via an end-joining mechanism that is Ku86 independent. PMID: 18541667

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KEGG: mmu:13870

STRING: 10090.ENSMUSP00000003645

UniGene: Mm.280913