Recombinant Mouse Dual specificity mitogen-activated protein kinase kinase 3 (Map2k3)

1. The study identifies MKK3 as a negative regulator of mitochondrial function and inflammatory responses to cigarette smoke. PMID: 27717867
2. ATF3 upregulation in cardiac fibroblasts in response to hypertensive stimuli protects the heart by suppressing Map2K3 expression and subsequent p38-transforming growth factor-beta signaling. PMID: 28249877
3. miR-21 targets MKK3 in vivo and in vitro, inhibiting the downstream factors IL-6 and TNF-alpha, in ischemia pretreatment protection from ischemia-reperfusion induced kidney injury. PMID: 26149640
4. miR-21a-5p inhibited BPA induced adipocyte differentiation by targeting map2k3 through MKK3/p38/MAPK in 3T3-L1 cells PMID: 26996129
5. this study demonstrates that MKK3 influences mitochondrial quality by affecting the expression of mitochondrial proteins, including TCA cycle enzymes, and mitophagy, which consequently regulates the inflammatory response. PMID: 26119780
6. Exendin-4 treatment improves cardiac function, attenuates cardiac remodeling, and promotes angiogenesis in the infarcted myocardium through MKK3 and Akt-1 pathway. PMID: 26739490
7. Our results suggest that asthma is associated with MKK3 over-expression in CD8+ cells; we have also demonstrated that MKK3 may be critical for airway neutrophilia PMID: 24480516
8. MKK3 and MKK6 differentially regulate bone loss due to estrogen withdrawal. MKK3 directly mediates osteoclastogenesis while MKK6 likely contributes to pro-inflammatory cytokine production that promotes osteoclast formation. PMID: 24400116
9. results designate MKK3 as a novel, positive regulator of SCF-induced mast cell proliferation and a critical signaling protein for AP-1-dependent IL-6 production PMID: 24453276
10. findings demonstrate a critical role for mitochondria in the pathogenesis of sepsis that involves a previously unrecognized function of MKK3 in mitochondrial quality control PMID: 24487387
11. Endothelial MKK3 is neede for inflammatory cell recruitment to the lungs, mitochondrial oxidant-mediated AP-1, NF-kappaB activation, & ICAM-1 expression during LPS challenge. PMID: 23275604
12. mast cell MKK3 signaling contributes to IgE-dependent allergic inflammation and is a specific regulator of FcepsilonRI-induced IL-4 production. PMID: 21841136
13. Studies identified FOXM1 as a key downstream target of Ras-MKK3-p38 regulated in vitro cellular invasion. PMID: 20023695
14. Activation of distinct p38MAPK isoforms is regulated by the selective and synchronized action of two kinases, MKK3 and MKK6, in response to cell stress. PMID: 20004242
15. MKK3 is upregulated in peripheral CD4(+)T cells PMID: 12151339
16. MKK3 is a critical component of the TGF-beta1 signaling pathway, and its activation is required for subsequent p38alpha and p38delta MAPK activation and collagen stimulation by TGF-beta1 PMID: 12374793
17. MKK3 is one of three protein kinases which activate p38 MAPK in vitro. PMID: 12893778
18. Cytoprotective effects of carbon monoxide are mediated by selective activation of the MKK3/p38 beta protein MAP kinase pathway. PMID: 14633627
19. MKK3 and MKK6 are rapidly activated during engagement of the Type I IFN receptor and play important roles in Type I IFN signaling and the generation of IFN responses PMID: 15644321
20. Caveolin-1 acts as a potent immunomodulatory effector molecule in immune cells and that the regulation of LPS-induced cytokine production by caveolin-1 involves the MKK3/p38 MAPK pathway. PMID: 16357362
21. All these results suggest that DGK may play a role in glucose transport in the skeletal muscle cells through modulating a MKK3/6-p38 signaling pathway. PMID: 17588539
22. Direct role for MKK3-p38 signaling in tubular apoptosis. Discrete roles for MKK3-p38 signaling in renal cell apoptosis and the early inflammatory response in the obstructed kidney. PMID: 17686961
23. MKK3 signalling plays an essential role in the development of islet inflammation leading to destruction of beta-cells and hyperglycaemia in pancreatic injury induced by multiple low doses of streptozotocin. PMID: 18283273
24. Mkk3 deficient diabetic mice are protected from tubular injury and interstitial fibrosis PMID: 19066844
25. MKK3, but not MKK6, is necessary for normal development of chronic pain behavior and phosphorylation of spinal p38. PMID: 19427893

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KEGG: mmu:26397

STRING: 10090.ENSMUSP00000019076

UniGene: Mm.18494