Recombinant Mouse G1/S-specific cyclin-E1 (Ccne1)

1. study suggests that hepatocellular carcinoma initiation specifically depends on CcnE1 and Cdk2, while HCC progression requires expression of any E-cyclin, but no Cdk2. PMID: 30150405
2. ChIP-sequence/ChIP studies indicated that Ad4BP/SF-1 binds to the upstream region of Ccne1 (cyclin E1) gene during G1/S phase. PMID: 28325912
3. These results demonstrate a repressor role for NFAT1 in cell cycle progression and Cyclin E expression in B lymphocytes, and suggest a potential function for NFAT1 protein in B cell malignancies. PMID: 27399331
4. This approach allowed us to determine the identity of cyclin E protein partners, as well as phosphorylation substrates of cyclins E (cyclin E1and cyclin E2)and its associated kinase, Cdk2, in different mouse organs. PMID: 27828963
5. Spermatocytes lacking cyclin E2 and one E1 allele (E1+/-E2-/-) displayed a high rate of telomere abnormalities but can progress to pachytene and diplotene stages. PMID: 26712234
6. Myb regulates Cyclin E1 expression in normal gastrointestinal tract epithelial cells and is required during intestinal tumorigenesis PMID: 25934694
7. These results highlight a new role for E-type cyclins (Ccne1 and Ccne2) as important regulators of male meiosis. PMID: 24586195
8. Concurrent deletion of cyclin E1 and cyclin-dependent kinase 2 in hepatocytes inhibits DNA replication and liver regeneration in mice. PMID: 23787781
9. Superoxide dismutase induces G1-phase cell cycle arrest by down-regulated expression of Cdk-2 and cyclin-E in sarcoma tumor cells. PMID: 23055394
10. Ablation of cyclin E led to a decreased number of synapses, reduced number and volume of dendritic spines, and resulted in impaired synaptic plasticity and memory formation. PMID: 21944720
11. Data show that gastric cancer markers MUC2, and oncogenes c-myc, cyclin E1 were expressed in the gastric carcinoma cell line 3I (MGCC3I). PMID: 20737421
12. our fi ndings reveal a direct link between cyclin E and HIF-1 activities in mammary epithelial cells and implicate HIF-1 as a mediator of proliferation-independent phenotypes associated with high cyclin E expression in some human breast cancers. PMID: 21746877
13. Report presents the first detailed analysis of cyclin E expression in postmitotic neurons during development and in the adult mouse brain PMID: 20863901
14. Results show that deregulation of cyclin E expression contribute to infertility, due to inability of the spermatogonial cells to start the mitotic cycles prior to entering meiosis. PMID: 20962587
15. Depletion of cyclin E promoted apoptosis of breast cancer cells and blocked proliferation and transformation. PMID: 20877462
16. These results suggest that cyclin E up-regulation and p27(Kip1) loss-of-function act cooperatively on pituitary adenoma development. PMID: 20660298
17. Data show that liver-specific ablation of the cyclin E regulator Cullin 3 in mice results in the persistence and massive expansion of hepatic progenitor cells. PMID: 20978349
18. cyclin E has a role in megakaryocytic polyploidization PMID: 20392692
19. Cyclin E is a target of WT1 transcriptional repression PMID: 11919196
20. Involvement of CDK2/cyclin E and nucleophosmin/B23 in centrosome duplication PMID: 12429912
21. Data suggest that the interaction between PKCeta and cyclin E is carefully regulated, and is correlated with the inactivated form of the cyclin E/Cdk2 complex. PMID: 12729791
22. These findings define a molecular function for E type cyclins (cyclins E1 and E2) in cell cycle reentry and reveal a differential requirement for cyclin E in normal versus oncogenic proliferation. PMID: 12941272
23. During embryonic development, the needs for this cyclin can be overcome in mitotic cycles but not in endoreplicating cells. PMID: 12970191
24. essential functions for Fbw7 in controlling cyclin E and Notch signaling pathways PMID: 14766969
25. This work indicates that-in addition to their function as CDK activators-E cyclins play kinase-independent functions in cell-cycle progression. PMID: 17218276
26. cyclin E has a role in dysplasia and multiple pulmonary adenocarcinomas PMID: 17360482
27. Akt-mediated liver growth promotes induction of cyclin E through a novel translational mechanism and a p21-mediated cell cycle arrest PMID: 17517888
28. Overexpression of the low molecular weight cyclin E in transgenic mice induces metastatic mammary carcinomas through the disruption of the ARF-p53 pathway PMID: 17671189
29. Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo. PMID: 18559482
30. a mechanism for the G(1)/S regulation with increased levels of p27(Kip1) binding to Cdk1/cyclin E complexes was elicited in Cdk2(-/-)Cdk4(-/-)Rb(-/-) (TKO) mutant mice embryonic fibroblasts PMID: 19129496
31. Data indicate that the CDK2/cyclin E/p220(NPAT)/HINFP/histone gene signaling pathway at the G1/S phase transition is an essential, nonredundant cell cycle regulatory mechanism that is established early in embryogenesis. PMID: 19590016
32. By interacting with Ku70, a cyclin E fragment liberates Bax, which participates in apoptosis by sustaining a positive feedback loop targeting mitochondria. This process is independent of p53 and new RNA or protein synthesis. PMID: 17581275

Show More

Hide All

KEGG: mmu:12447

STRING: 10090.ENSMUSP00000103658

UniGene: Mm.16110