Recombinant Mouse Glycogen synthase kinase-3 alpha (Gsk3a)

1. GSK-3 plays a significant role in astrocyte development and behavioral control in mice. PMID: 26179612
2. Data suggest that, in embryonic stem cells, Gsk3b/Gsk3a phosphorylate splicing factors (Rbm8a, Srsf9, and Psf) and nucleolar proteins (Npm1 and Phf6); Gsk3b/Gsk3a are key to alternative splicing of close to 190 genes. (Gsk3 = glycogen synthase kinase-3; Rbm8a = RNA binding motif protein 8a; Srsf9 = splicing factor, arginine-serine-rich 9; Psf = replication protein Psf; Npm1 = nucleophosmin 1; Phf6 = PHD finger protein 6) PMID: 28916722
3. GSK3 is regulated through mechanisms independent of N-terminal serine phosphorylation in order for beta-catenin to be stabilized. PMID: 27284979
4. The expression of PI3K-insensitive GSK3 stimulates the production of adiponectin and protects from diet-induced metabolic syndrome. PMID: 27140617
5. Cardiac myocyte GSK-3a is required to maintain normal cardiac homeostasis and loss leads to severe fatal dilated cardiomyopathy. PMID: 26976650
6. reveals that GSK-3alpha- and GSK-3beta-regulated pathways can be responsible for stepwise transition to myelodysplastic syndromes and subsequent acute myeloid leukemia PMID: 26766591
7. Gsk3 play a role in the maintenance of DNA methylation at a majority of the imprinted loci in embryonic stem cells PMID: 25833708
8. Sperm GSK3A is essential for male fertility. PMID: 25568307
9. The absence of oocyte GSK3 isoforms in the periconceptional period does not alter fertility yet causes offspring cardiac hyperplasia, cardiovascular defects, and significant neonatal death. PMID: 25833158
10. results support the model that GSK3 activity status is regulated by the circadian clock and that GSK3 feeds back to regulate the molecular clock amplitude in the suprachiasmatic nucleus PMID: 25724980
11. Gsk3-deleted neurons expressing upper layer markers exhibited striking migration failure in all areas of the cortex. PMID: 25073924
12. PI3K/AKT-mediated inhibitory phosphorylation of GSK3 limits the regenerative outcome after peripheral nerve injury. PMID: 25078444
13. double-knockout embryonic stem cells, as well as GSK-3beta(-/-) mouse embryonic fibroblast cells in which GSK-3alpha was knocked down to demonstrate that both isoforms of GSK-3, GSK-3alpha and GSK-3beta, are required for antiviral immune response. PMID: 26100021
14. ER stress-PERK-GSK3alpha/beta signaling promotes proatherogenic macrophage lipid accumulation PMID: 25183803
15. The two isoforms of GSK-3 are essential integrators of multiple developmental signals that act to maintain normal mammary gland function and suppress tumorigenesis. PMID: 25195860
16. identify a key role for GSK3 alpha and beta in the regulation of sperm maturation and acrosomal exocytosis PMID: 25808536
17. GSK3alpha plays a pro-atherogenic role, possibly by mediating the effects of endoplasmic reticulum stress in the activation of pro-atherogenic pathways in high fat diet-fed low density lipoprotein receptor-deficient mice PMID: 25451156
18. Results show that GSK3alpha rather than GSK3beta is essential for bidirectional synaptic plasticity in the Schaffer collateral to CA1 synapse PMID: 25208523
19. could play a crucial role in renal urine concentration PMID: 25608967
20. results demonstrate that GSK3beta, but not GSK3alpha, negatively controls the neuronal differentiation of progenitor cells and that GSK3beta may act downstream of the mammalian target of rapamycin complex1 signaling pathway. PMID: 24397546
21. Data show that microtubule actin crosslinking factor 1 (MACF1) determines neuronal positioning by regulating microtubule dynamics and mediating glycogen synthase kinase 3 (GSK-3) signaling during brain development. PMID: 25224226
22. reducing GSK-3alpha expression in cardiomyocytes limits ventricular remodeling and preserves cardiac function post-MI. PMID: 25125302
23. GSK-3-alpha inhibition causes large increases in TNF-alpha secretion by lipopolysaccharide-stimulated cells in the murine dorsal air-pouch model. PMID: 24803542
24. Dysregulation of NMDA receptors by altered GSK-3 signaling may be a key pathophysiologic mechanism for Alzheimer's disease. PMID: 24094580
25. GSK3alpha contributes to the pathological phosphorylation of protein Tau. PMID: 23705847
26. GSK3alpha, GSK3beta, and MAPK13 were found to be the most active tau kinases, phosphorylating tau at all four epitopes. PMID: 23798682
27. A completely novel role of protein kinase B/Akt and glucocorticoid inducible kinase (SGK) dependent GSK3alpha,beta phosphorylation is observed, i.e., the regulation of cytosolic Ca2+ concentration in dendritic cells. PMID: 23817039
28. GSK-3alpha and GSK-3beta are required for the regulation of activity-dependent dendritic growth. PMID: 23470087
29. GSK-3alpha is a critical regulator of mTORC1, autophagy, and aging. PMID: 23549082
30. GSK3alpha mutants were viable, while GSK3beta mutants died after birth with a complete cleft palate. PMID: 23185619
31. High brain levels of GSK3alpha and large fluctuations in its levels and phosphorylation in the juvenile and adolescent mouse brain raise. PMID: 23167932
32. PKCalpha and Akt modulate platelet function by phosphorylating and inhibiting GSK3alpha/beta, thereby relieving the negative effect of GSK3alpha/beta on thrombin-mediated platelet activation. PMID: 23239877
33. PKB/Akt and SGK sensitive phosphorylation of GSK3alpha,beta is a potent regulator of perforin expression and activation induced cell death in T lymphocytes. PMID: 22814108
34. GSK3alpha formed a constitutive complex to phosphorylate and suppress AKT activation. PMID: 23142783
35. Inhibition of the MEK1/ERK pathway mediates the hypertrophy suppression and cardiac dysfunction caused by GSK-3alpha overexpression in cardiac myocytes. PMID: 22904158
36. The inhibitory phosphorylation of GSK3alpha on serine-21 was increased in hippocampus & cerebral cortex 30 & 60 min after intraperitoneal ketamine injection. Total levels of GSK3alpha were unaltered. Ketamine modulates its phosphorylation not expression. PMID: 21502951
37. redundant functions of GSK-3alpha and GSK-3beta through phosphorylation of RelA at Thr-254 play a crucial role in early stages of chondrocyte differentiation. PMID: 22761446
38. GSK3 inhibitor-BIO regulates proliferation of immortalized pancreatic mesenchymal stem cells PMID: 22384031
39. data from both approaches suggest that GSK-3alpha contributes to both SP and NFT pathogenesis while GSK-3beta only modulates NFT formation. PMID: 22623685
40. The cardioprotective effects of GSK-3alpha in the setting of ischemia and infarction appear to be substantial. PMID: 22086876
41. lattice-binding activity mediates axon growth inhibition induced by suppression of GSK3 activity via preventing microtubule protrusion into the growth cone periphery PMID: 21937714
42. Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation. PMID: 21685889
43. insulin-sensitization observed in the out-bred strain of mice lacking GSK-3alpha is mediated by indirect means that do not require intrinsic function of GSK-3alpha in skeletal muscle and liver tissues PMID: 21253590
44. Study provides insights into both skeletal development and the biology of GSK-3alpha and GSk-3beta proteins. PMID: 21325041
45. findings clearly implicate both GSK-3alpha- and GSK-3beta-dependent mechanism of neuronal pentraxin 1 induction PMID: 21130869
46. These data support a role for the GSK-3alpha gene in central nervous system functioning and possible involvement in the development of psychiatric disorders. PMID: 19925672
47. Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci Dnmt3a2, and misexpression of Igf2, H19, and Igf2r PMID: 21047779
48. gastric acid secretion is significantly enhanced in mice expressing protein kinase B/serum-glucocorticoid regulated kinase-insensitive GSK3a,b, disclosing a novel signaling molecule involved in the regulation of gastric acid secretion PMID: 20552232
49. The chronic remodelling response to infarction in hearts of GSK-3alpha/beta(Ala21/9) knockin (KI) mice encoding constitutively active GSK-3 isoforms, was determined. PMID: 20696171
50. impaired inhibitory regulation of GSK3 in Fmr1 knockout mice may contribute to some socialization deficits PMID: 20300527

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KEGG: mmu:606496

STRING: 10090.ENSMUSP00000071654

UniGene: Mm.491101