Glycogen synthase kinase-3 alpha is a protein in humans that is encoded by GSK3A gene. Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease.
The following GSK3A reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
GSK3A Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA009962GA01HU | GSK3A Antibody |
Human,Mouse,Rat | ELISA,WB |
CSB-PA144022 | Phospho-GSK3A (Ser21) Antibody |
Human,Mouse,Rat | ELISA,WB,IHC,IF |
CSB-PA282922 | GSK3A (Ab-21) Antibody |
Human,Mouse,Rat | ELISA,WB,IHC,IF |
CSB-PA205981 | GSK3A Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA000534 | Phospho-GSK3A (S21) Antibody |
Human,Mouse,Rat | WB, IHC, IP, ELISA |
CSB-PA002836 | GSK3A Antibody |
Human,Mouse,Rat | WB, IHC, IP, ELISA |
CSB-PA147596 | GSK3A Antibody |
Human | ELISA,IHC |
CSB-PA932427 | GSK3A Antibody |
Human | ELISA,IHC |
CSB-PA05369A0Rb | GSK3A Antibody |
Human | ELISA, WB, IF |
CSB-PA05369D0Rb | GSK3A Antibody, Biotin conjugated |
Human | ELISA |
CSB-RA009962A216phHU | Phospho-GSK3A/GSK3B (Y216 + Y279) Recombinant Monoclonal Antibody |
Human | ELISA, IHC |
GSK3A Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP009962RA CSB-EP009962RA CSB-BP009962RA CSB-MP009962RA CSB-EP009962RA-B |
Recombinant Rat Glycogen synthase kinase-3 alpha (Gsk3a) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GSK3A Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP009962HU CSB-EP009962HU CSB-BP009962HU CSB-MP009962HU CSB-EP009962HU-B |
Recombinant Human Glycogen synthase kinase-3 alpha (GSK3A) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GSK3A Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP649920MO CSB-EP649920MO CSB-BP649920MO CSB-MP649920MO CSB-EP649920MO-B |
Recombinant Mouse Glycogen synthase kinase-3 alpha (Gsk3a) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |