GSK3A

GSK3A, a multifunctional Ser/Thr protein kinase present throughout the body with higher concentrations in the brain and testes, modulates a range of proteins, including glycogen synthase and transcription factors like JUN. It influences the Wnt and PI3K pathways and impacts the generation of beta amyloid peptides, which are linked to Alzheimer's disease. GSK3A's influence extends to cell proliferation, differentiation, and apoptosis, playing a role in the development of neurodegenerative diseases, diabetes, inflammation, and cancer. As a significant regulatory molecule, GSK3A's activity offers potential targets for therapeutic intervention across various diseases.