Recombinant Mouse Guanine nucleotide-binding protein G (i) subunit alpha-1 (Gnai1)

1. LGN and Galphai participate in a long-inferred signal that originates outside the bundle to model its staircase-like architecture, a property that is essential for direction sensitivity to mechanical deflection and hearing. PMID: 27660326
2. stimulation of GPR17 by the small molecule agonist MDL29,951 (2-carboxy-4,6-dichloro-1H-indole-3-propionic acid) decreases myelin basic protein expression levels mainly by triggering the Galphai/o signaling pathway. PMID: 26620557
3. Gnai1 missense mutation is responsible of hyperpigmentation in mouse model. PMID: 26763459
4. acidosis in inflamed tissues may be a decisive factor to regulate switching of PKA and PKCepsilon dependence via proton-sensing G-protein-coupled receptors. PMID: 25933021
5. By using mice deficient in individual Galphai/o G-protein subunits, authors demonstrate that Galphai1 and Galphai3 are the critical in vivo targets of ADP-ribosylation underlying vasoactive amine sensitization elicited by pertussis toxin exposure. PMID: 24478091
6. leucine can directly facilitate insulin signaling through a Galphai protein-dependent intracellular signaling pathway PMID: 23404499
7. Inactive Galpha(i1)-GDP enhances the affinity of RGS14 for H-Ras-GTP in live cells, resulting in a ternary signaling complex that is further regulated by G protein-coupled receptors. PMID: 23250758
8. Mice with mutations of Gnai1 or Gnai2 have neither fusions of ribs nor lumbar vertebrae, but loss of both Gnai3 and one of the other two genes increases the number and severity of rib fusions without affecting the lumbar fusions. PMID: 23236180
9. Results suggest a model in which the Gbetagamma dimer that is released as a result of the dissociation from Galpha(o) upon activation of mGluR6 closes the TRPM1 channel, perhaps via a direct interaction. PMID: 22586107
10. RGS14 can form complexes with GPCRs in cells that are dependent on Galpha(i/o) and these RGS14.Galpha(i1).GPCR complexes may be substrates for other signaling partners such as Ric-8A PMID: 21880739
11. The decrease in beta(2)-AR may account for additional relaxation impairment, given that there is no enhancement over nontransgenic after pertussis toxin, despite AC5 overexpression. PMID: 21131397
12. Data show that mice lacking G(o2)alpha, but not those lacking alpha subunits of either G(o1) or any G(i) proteins, handle glucose loads more efficiently than wild-type (WT) mice. PMID: 21220323
13. Activation of the Rsg14-Galphai1-GDP signaling complex is regulated by Ric8. PMID: 21158412
14. analysis of a novel Gi, P2Y-independent signaling pathway mediating Akt phosphorylation in response to thrombin receptors PMID: 20586915
15. CKbeta8- and CKbeta8-1-induced activation of ERK1/2 is mediated by the G(i)/G(o) protein, PLC, and PKCdelta. PMID: 20097574
16. Gi-mediated signaling pathways are activated by G12/G13 and are sufficient to induce integrin alpha(IIb)beta3 activation PMID: 12183468
17. Gi, but not Gq or G12/13, signaling pathways are required for activation of Akt in platelets PMID: 14623889
18. Loss of G(ialpha1) amplifies the responsiveness of CA1 postsynaptic neurons to stimuli that strengthen synaptic efficacy, thereby diminishing synapse-specific plasticity required for new memory formation. PMID: 14715142
19. Galpha (i) is activated and subsequently uncoupled from receptor-Galpha(i) signaling by Pasteurella multocida toxin PMID: 18583341
20. Report role of Gnai1 in the control of in vivo heart rate dynamics. PMID: 18832081
21. PKA and GRK phosphorylation of the beta(2)AR has distinct roles for agonist dose-dependent coupling to G(i) proteins in cardiac myocytes PMID: 19706594

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KEGG: mmu:14677

STRING: 10090.ENSMUSP00000074259

UniGene: Mm.254629