GNAI1

GNAI1 encodes the G protein subunit alpha i1 (Gαi1), a core component of heterotrimeric G proteins in the Gi/o family. Common aliases include Gαi-1 and GNAI-1. It transduces signals from G protein-coupled receptors (GPCRs) by inhibiting adenylyl cyclase, lowering intracellular cyclic adenosine monophosphate (cAMP) levels to regulate processes like cell proliferation and neurotransmission.
Dysregulated GNAI1 is linked to colorectal cancer (overexpression drives tumor growth) and neurodevelopmental disorders such as intellectual disability. Direct therapeutics targeting Gαi1 remain preclinical, but research focuses on modulating GPCR-Gαi1 signaling pathways, with potential for oncology and neurology applications.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

The following GNAI1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

GNAI1 Antibodies

GNAI1 Proteins

GNAI1 Antibodies

GNAI1 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA009588GA01HU	GNAI1 Antibody	Human,Mouse,Rat	ELISA,WB,IHC

GNAI1 Proteins

GNAI1 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP009588RA CSB-EP009588RA CSB-BP009588RA CSB-MP009588RA CSB-EP009588RA-B	Recombinant Rat Guanine nucleotide-binding protein G (i) subunit alpha-1 (Gnai1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

GNAI1 Proteins for Cavia porcellus (Guinea pig)

Code	Product Name	Source
CSB-YP009588GU CSB-EP009588GU CSB-BP009588GU CSB-MP009588GU CSB-EP009588GU-B	Recombinant Guinea pig Guanine nucleotide-binding protein G (i) subunit alpha-1 (GNAI1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

GNAI1 Proteins for Gallus gallus (Chicken)

Code	Product Name	Source
CSB-YP009588CH CSB-EP009588CH CSB-BP009588CH CSB-MP009588CH CSB-EP009588CH-B	Recombinant Chicken Guanine nucleotide-binding protein G (i) subunit alpha-1 (GNAI1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

GNAI1 Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP009588BO CSB-EP009588BO CSB-BP009588BO CSB-MP009588BO CSB-EP009588BO-B	Recombinant Bovine Guanine nucleotide-binding protein G (i) subunit alpha-1 (GNAI1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

GNAI1 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP009588HU CSB-MP009588HU CSB-EP009588HU-B	Recombinant Human Guanine nucleotide-binding protein G (i) subunit alpha-1 (GNAI1)	Yeast Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP009588HU	Recombinant Human Guanine nucleotide-binding protein G (i) subunit alpha-1 (GNAI1)	E.coli
CSB-BP009588HUd7	Recombinant Human Guanine nucleotide-binding protein G(i) subunit alpha-1 (GNAI1)	Baculovirus
CSB-BP009588HU	Recombinant Human Guanine nucleotide-binding protein G(i) subunit alpha-1 (GNAI1)	Baculovirus

GNAI1 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP009588MO CSB-EP009588MO CSB-BP009588MO CSB-MP009588MO CSB-EP009588MO-B	Recombinant Mouse Guanine nucleotide-binding protein G (i) subunit alpha-1 (Gnai1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

GNAI1 Proteins for Oryzias latipes (Japanese rice fish) (Japanese killifish)

Code	Product Name	Source
CSB-YP308566OFH CSB-EP308566OFH CSB-BP308566OFH CSB-MP308566OFH CSB-EP308566OFH-B	Recombinant Oryzias latipes Guanine nucleotide-binding protein G (i) subunit alpha-1	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

GNAI1 Proteins for Xenopus laevis (African clawed frog)

Code	Product Name	Source
CSB-YP333220XBE CSB-EP333220XBE CSB-BP333220XBE CSB-MP333220XBE CSB-EP333220XBE-B	Recombinant Xenopus laevis Guanine nucleotide-binding protein G (i) subunit alpha-1	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

GNAI1 Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

Code	Product Name	Source
CSB-YP725363PYX CSB-EP725363PYX CSB-BP725363PYX CSB-MP725363PYX CSB-EP725363PYX-B	Recombinant Pongo abelii Guanine nucleotide-binding protein G (i) subunit alpha-1 (GNAI1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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GNAI1

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