Recombinant Mouse Interferon regulatory factor 5 (Irf5)

1. Scavenger receptor class A is regulated by pathogens and suppresses IRF5 nuclear translocation by direct interaction. Reduced abundance of nuclear IRF5 shifts macrophage polarization from M1 towards M2, which subsequently switches T-helper responses from type 1 to type 2. PMID: 28695899
2. Aged mice expressed higher IRF5 levels in the ischemic brains, suggesting that aging has a significant influence on stroke outcomes in mice, which is probably mediated by age-specific inflammatory responses. PMID: 28905935
3. this study shows a critical role for IRF5 in regulating allergic airway inflammation PMID: 27759022
4. IRF5 and IRF5 disease-risk variants increase glycolysis and human m1 macrophage polarization by regulating proximal signaling and Akt2 activation. PMID: 27545875
5. these results reveal a role for Lyn as a specific suppressor of the TLR-MyD88-IRF5 pathway and illustrate the importance of fine-tuning IRF5 activity for the maintenance of immune homeostasis PMID: 27521268
6. IRF5 siRNA reverses pancreatitis-induced activation of lung macrophages from M1 phenotype to M2 phenotype in severe acute pancreatitis associated with acute lung injury. PMID: 27895424
7. Our data show that miR-146b targets IRF5, resulting in the regulation of macrophage activation. Furthermore, miR-146b deficient mice developed intestinal inflammation with enhanced M1 macrophage polarization. PMID: 27825654
8. data suggest that IRF5 plays a causal role in inflammation, fibrosis and impaired vascular EC function in Tsk/+ mice PMID: 27050551
9. Collectively, these results indicate a key role for IRF-5 in modulating the host antiviral response in peripheral organs that controls bunyavirus neuroinvasion in mice. PMID: 26468541
10. studies extend prior ones suggesting that inhibiting IRF5 might be useful for chronic macrophage-induced inflammation and suggest that IRF5 blockade would ameliorate more acute forms of inflammation, including lung injury PMID: 26283380
11. IRF5 plays an important role in the development of disease in the MRL/lpr mouse model of lupus in the absence of the DOCK2 mutation and that IRF5 is required for the transition from mature B cells to plasma cells. PMID: 25076492
12. IRF5 expression in microglia is regulated by IRF8. IRF5 directly upregulates P2RX4 expression on microglia in peripheral nerve injury, and may play a role in neuropathic pain. PMID: 24818655
13. PAR1 suppression of IRF5 and IL-12/23 secretion by macrophages provides a novel mechanism by which the host suppresses the mucosal Th1 and Th17 response to H. pylori infection. PMID: 24866378
14. This study uncovers a new function for IRF5 in controlling the relative mass of different adipose tissue depots and thus insulin sensitivity in obesity. PMID: 25939064
15. IKKbeta is an IRF5 kinase that instigates inflammation PMID: 25326420
16. our results reveal a protective role for IRF5 in lupus-associated atherosclerosis that is mediated through the effects of IRF5 in both immune and nonimmune cells. PMID: 25595782
17. IRF5 has a critical role in shaping the early innate immune response towards West Nile virus in the draining lymph node, which impacts the spread of virus infection, optimal B cell immunity, and disease pathogenesis. PMID: 25031348
18. The IRF5 deficiency reduces IFN-alpha, IFN-beta and IL-6 production by Toll-like receptor 9 (TLR9)- and TLR7-stimulated DCs and reduces TLR7- and TLR9-induced IL-6 production by B cells PMID: 23291967
19. establish the species-invariant role of IRF5 in controlling the inflammatory macrophage phenotype both in vitro and in in vivo PMID: 24453413
20. These proteins were upregulated in Irf5(-/-) mice. PMID: 23912454
21. Reduction of IRF5 expression, a factor that regulates macrophage polarization, reduced expression of inflammatory M1 macrophage markers, supported resolution of inflammation, accelerated cutaneous and infarct healing PMID: 24361318
22. IRF5 levels in Tsk(-/+) hearts were similar to control. PMID: 23251680
23. Our results establish IRF-3, -5, and -7 as the key transcription factors responsible for mediating the type I IFN and IFN stimulated gene response in myeloid dendritic cells during WNV infection and suggest a novel signaling link between MAVS and IRF-5. PMID: 23300459
24. Our results show that IRF5 is a crucial driver of lupus development in mice. PMID: 21305501
25. Irf5-deficient monocytes are defective in their response to peritoneal lavage of pristane-injected mice; pristane-induced Ly6C(hi) antigen-producing monocyte recruitment to the peritoneal cavity is impaired in Irf5-deficient mice. PMID: 22933628
26. these results identify the IRF-5-Ikaros axis as a critical modulator of IgG2a/c class switching. PMID: 22535200
27. overexpression of IRF5 in blood cells of systemic lupus erythematosus(SLE) patients may contribute to disease pathogenesis. PMID: 22678902
28. uncovered a new, IFN-I-independent role of IRF5 in regulating chemokines involved in the homing of pDCs and certain lymphocyte subsets. PMID: 22422888
29. A spontaneous genomic duplication and frameshift mutation in the guanine exchange factor dedicator of cytokinesis 2 (Dock2) that has arisen in at least a subset of circulating Irf5(-/-) mice and inadvertently been bred to homozygosity. PMID: 22431588
30. the IRF5/Blimp-1 axis differentially regulates the expression of Nba2 lupus susceptibility genes, and they suggest an important role for the IRF5/Blimp-1/p202 axis in murine lupus susceptibility. PMID: 22116829
31. The authors show that the myxoma virus-induced innate immune response requires TLR9 and its adaptor MyD88, transcription factors IRF5 and IRF7, and the type I interferon positive-feedback loop mediated by IFNAR1. PMID: 21835795
32. Levels of Irf5 mRNA and protein were higher in females than in age-matched males. PMID: 20802013
33. Demonstrate a requirement for IRF5 in the development of SLE via its role in B cells. Antinuclear autoantibodies and Ig glomerular deposits, hallmarks of SLE, are absent in Irf5(-/-) mice challenged to develop SLE by pristane injection. PMID: 20479222
34. Data show the role of IRF-5 in the B-cell terminal differentiation. PMID: 20176957
35. IRF5 plays an essential role in lupus pathogenesis in murine models and this is mediated through pathways beyond that of type I IFN production PMID: 20007534
36. study identifies IRF-5 as a new, principal downstream regulator of the TLR-MyD88 signalling pathway and a potential target of therapeutic intervention to control harmful immune responses PMID: 15665823
37. we also provide evidence that this TLR synergy is mediated, at least in part, by activation of the transcription factor interferon regulatory factor 5 (IRF5). PMID: 17275788
38. IRF5 is critical for antiviral immunity and for the induction of apoptosis, but not cell cycle arrest in response to DNA damage, and acts as a tumor suppressor on a pathway that may be distinct from that for p53. PMID: 17360658
39. IRF5 plays a critical role in interferon (IFN)-alpha and IFN-beta production induced not only by RNA-containing immune complexes but also by conventional Toll-like receptor (TLR)7 and TLR9 ligands. PMID: 17513736
40. reveal a cell-type-specific function for IRF5 in the complex regulatory mechanism of death-receptor-induced apoptosis PMID: 18268344
41. reveal the cell type-specific importance of IRF-5 in MyD88-mediated antiviral pathways and the widespread role of IRF-5 in the regulation of inflammatory cytokines PMID: 18332133
42. Data show that IRF-5, which is activated via the MyD88 pathway, is subjected to TRAF6-mediated K63-linked ubiquitination, which is important for IRF-5 nuclear translocation and target gene regulation. PMID: 18824541
43. The functional characterization of the novel IRF-5 mutant in transformed B and T cell lines and in ATL and CLL patients may lead to a better understanding of the role of these transcriptional regulators in hematopoietic malignancies. PMID: 19430534

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KEGG: mmu:27056

STRING: 10090.ENSMUSP00000004392

UniGene: Mm.6479