Recombinant Mouse Interleukin-1 receptor-associated kinase 1 (Irak1)

1. Findings demonstrate that the pro- and anti-inflammatory responses to gAd in innate immune cells are time-dependent, and mediated by the activation of the IkappaB/NF-kappaB pathway, and IRAK-1 downregulation, respectively. PMID: 30078230
2. suppression of inflammatory responses and T cells apoptosis were observed with elevated expression of IRAK-M and PDL-1, and interference and neutralization of these 2 molecules led to partly reversed suppression of inflammation. PMID: 29995830
3. The expression of IL-1 receptor-associated kinase 1 (IRAK1) that regulates NF-kappaB, p38, and the JNK signaling pathways, was also increased by MPQP. PMID: 29804558
4. role of microRNA-146a in regulating the expression of IRAK1 in cerebral ischemia-reperfusion injury PMID: 29505740
5. These findings demonstrate that Dectin-1, Irak1, and Rip2 are involved in response to Aspergillus fumigatus infection. Dectin-1 modulates the expression of Irak1 and Rip2. PMID: 29058172
6. MiR-146a/ MiR-146b could down-regulate the TRAF6 and IRAK1 expression and promote proliferation, migration and angiogenesis ability of endothelial progenitor cells, which could be important for recovery of patients with hyperacute ischemic stroke. PMID: 28811005
7. miR-146a inhibits inflammatory cytokine production in B cells through directly targeting IRAK1, suggesting a regulatory role of miR-146a in B cell-mediated periodontal inflammation. PMID: 29288795
8. NLRC3 promoted K48-linked polyubiquitination and degradation of interleukin-1 receptor-associated kinase 1 (IRAK1). PMID: 28731142
9. these findings identify a transcription-independent, rapid, and nongenomic glucocorticoid suppression of TLR9 ligand-mediated IRAK1 ubiquitination as a novel mechanism for restraining acute inflammatory reactions PMID: 29038250
10. These results suggest that the IRAK1-binding protein OPTN negatively regulates IL-1beta/LPS-induced NF-kappaB activation by preventing polyubiquitination of TRAF6. PMID: 28882891
11. Data, including data from studies in knockout mice, suggest that Irak1 is involved in regulating glucose metabolism and insulin sensitivity in skeletal muscle (but not in liver and not in obesity due to high-fat diet); insulin sensitivity is 30% higher in Irak1 knockout mice on chow diet, but Irak1 deletion does not affect development of glucose intolerance due to high-fat diet. PMID: 28572512
12. Suppression of IRAK1 or IRAK4 Catalytic Activity, but Not Type 1 IFN Signaling, Prevents Lupus Nephritis in Mice Expressing a Ubiquitin Binding-Defective Mutant of ABIN1 PMID: 27807192
13. Torreya nucifera butanol fraction exhibits anti-inflammatory activities by direct inhibition of macrophage Src/Syk/NF-kappaB and IRAK1/AP-1 signaling. PMID: 27178629
14. IRAK1 is involved in TLR4-mediated downregulation of ABCA1 expression and lipid accumulation in VSMCs. PMID: 26512959
15. plays an important role in intestinal inflammation by mediating T cell activation, differentiation, and accumulation in the gut PMID: 26561545
16. Mangiferin ameliorates colitis by inhibiting IRAK1 phosphorylation in NF-kappaB and MAPK pathways PMID: 24972244
17. miR-146a ameliorates liver ischemia/reperfusion injury in vivo and hypoxia/reoxygenation injury in vitro by directly suppressing IRAK1 and TRAF6. PMID: 24987958
18. miR-146a attenuates sepsis-induced cardiac dysfunction by preventing NF-kappaB activation, inflammatory cell infiltration, and inflammatory cytokine production via targeting of IRAK and TRAF6 in both cardiomyocytes and inflammatory monocytic cells. PMID: 26048146
19. IRAK1 deficiency impacts multiple TLR-dependent pathways and decreases early cytokine responses following polymicrobial sepsis. PMID: 23856940
20. CD40 signaling induces IRAK1 sumoylation in the presence of TNF receptor-associated factor 2 (TRAF2) and intracellular isoform of osteopontin PMID: 24706909
21. Mosaicism for IRAK1 expression is accompanied by skewing toward deficient immune cell populations, producing a phenotype that is preconditioned for improved sepsis outcome PMID: 24193737
22. IRAK-1 bypasses priming and directly links Toll-like receptors to rapid NLRP3 inflammasome activation. PMID: 24379360
23. Data indicate that IRAK1 is required for LMP1-induced CaMKII activation and p65/RelA serine 536 phosphorylation. PMID: 24248603
24. These findings define the pathways that lead to rapid NLRP3 activation and identify IRAK1 as a critical mediator of a transcription-independent, inflammasome-dependent early warning response to pathogenic infection. PMID: 24043892
25. Irak1 accumulation triggers I/R-induced epithelial immune hyper-responsiveness and suggest that the induction of miR-146a offers a promising strategy to prevent I/R tissue injury PMID: 23143987
26. Data indicate that kalopanaxsaponin B ameliorates lipopolysaccharide (LPS)-induced systemic inflammation by inhibiting IRAK1 kinase. PMID: 23117333
27. rhinovirus infection delays bacterial clearance in vivo and suppresses non-typeable Hemophilus influenzae-stimulated chemokine responses via degradation of IRAK-1 PMID: 23055935
28. p16(INK4a) exerts an anti-inflammatory effect through accelerated IRAK1 degradation in macrophages. PMID: 23066149
29. Endogenous IRAK-M attenuates adverse postinfarction remodeling suppressing leukocyte inflammatory activity, while inhibiting fibroblast-mediated matrix degradation. PMID: 22995519
30. Low-dose lipopolysaccharide utilizes IRAK-1 and Tollip to induce mitochondrial reactive oxygen species, which subsequently induces activating transcription factor (ATF)2 in chronic low-grade inflammatory disease. PMID: 22706082
31. TLR2 inhibits IFN-I induction by TLR7/9, may shape immune responses to microbes that express ligands for both TLR2 and TLR7/TLR9, or responses to bacteria/virus coinfection. PMID: 22227568
32. we have provided first-hand evidence demonstrating the in vivo beneficial effect of IRAK-1 deficiency in LPS-induced oxidative tissue damage and injury PMID: 22364946
33. Endotoxin uses a distinct pathway to initiate low-grade inflammation in macrophages, requiring interaction with IRAK-1 upstream of IkappaB kinase epsilon to contribute to the induction of C/EBPdelta and proinflammatory mediators. PMID: 21357541
34. Increased Smad3 linker phosphorylation at Thr-179 and Ser-208 and was dependent on ERK1/2 activity via the TLR4-IRAK1-linked signaling cascade. PMID: 21295571
35. Although IRAK1 kinase activity is essential for human plasmacytoid dendritic cell activation, it is dispensable in B, T, dendritic, and monocytic cells, which is in contrast with an essential active kinase role in comparable mouse cell types. PMID: 21160042
36. Leptin increases the expression of IRAK-1 in murine macrophages. IRAK-1 deficient macrophages exhibit significantly lower expression of IL-6 following LPS or LPS plus leptin stimulation. PMID: 20619458
37. IRAK-1 forms a close complex with PKCepsilon as well as VASP, and participates in phorbol 12-myristate 13-acetate-induced phosphorylation of VASP. PMID: 20044140
38. Identification and characterization of murine IRAK-M. PMID: 12054681
39. novel splice site variant activates nuclear factor-kappaB and c-Jun N-terminal kinase PMID: 12418963
40. TIFA is likely to mediate IRAK-1/TRAF6 interaction upon IL-1 stimulation. PMID: 12566447
41. IRAK1 function, and by extension Toll/IL-1 signaling, is critical for the induction of experimental autoimmune encephalomyelitis as well as the activation and expansion of autoreactive T cells. PMID: 12626533
42. lipopolysaccharides (LPS) activate Toll/IL-1 signaling and IL-1 receptor-associated kinase-1 (IRAK1), a critical pathway intermediate in the heart, indicating that the function of this pathway is not limited to immune system tissues. PMID: 12860565
43. induction of IRAK-M and inhibition of kinase activity of IRAK-1 are crucial to PGN-induced tolerance in macrophages PMID: 14660668
44. IRAK1 and TRAF6 are essential for LMP1-induced NF-kappaB activation. PMID: 14673102
45. IRAK-1 plays an important role in the host response to staphylococcal sepsis PMID: 15555532
46. IRAK-1 is a specific regulator for TLR7- and TLR9-mediated IFN-alpha induction in plasmacytoid dendritic cells. PMID: 15767370
47. Only LPS, not taxol, caused a dramatic decrease in Irak1 protein levels. PMID: 15829295
48. IRS-1 is a novel physiological substrate for pelle-like kinase PMID: 15849359
49. It is therefore concluded that intracellular localization of IRAK-1 depends on its kinase activity and that IRAK-1 may also function as a kinase in the nucleus as shown by a new putative endogenous substrate. PMID: 15896328
50. Curcumin blocked IRAK thiols in a murine T-cell line stably overexpressing IRAK. PMID: 16046709

Show More

Hide All

KEGG: mmu:16179

UniGene: Mm.38241