Recombinant Mouse Interleukin-12 subunit beta (Il12b)

1. In macrophages, SCIMP is constitutively associated with the Lyn tyrosine kinase, is required for tyrosine phosphorylation of TLR4, and facilitates TLR-inducible production of the IL-6 and IL-12p40. PMID: 28098138
2. Results show the overproduction of IL-12/23p40 in dendritic cells, leading to Th1 and Th17 programs in a mouse model of Yersinia enterocolitica-induced reactive arthritis. PMID: 29494692
3. this study demonstrates that regulation of IL-12p40 by hypoxia-inducible factor-1alpha controls Th1/Th17 responses to prevent mucosal inflammation PMID: 28120851
4. the nuclear localized CA-VI B selectively promotes IL-12 expression by interaction with protein arginine N-methyltransferase 5 (PRMT5), which reduces symmetric dimethylation of histone H3 arginine 8 modification (H3R8me2s) at Il12 promoters to facilitate chromatin accessibility, selectively enhancing c-Rel binding to the Il12b promoter. PMID: 28739930
5. High dilutions of antimony modulate cytokines production and macrophage - Leishmania (L.) amazonensis interaction in vitro.( PMID: 28092793
6. IL-12p40 depletion in mice could promote ectopic bone formation. PMID: 27472064
7. Data indicate that there was a differential transcription of 381 genes which changed greater than two fold in B1a of p40-/-IL-2Ralpha-/- mice. PMID: 27105495
8. this study shows that endosomal signalling by Lactobacillus acidophilus that leads to IL-12 production is inhibited by TLR stimulation from the plasma membrane PMID: 27441725
9. Furthermore, IL-12p40-/- mice showed decreased sensitization to inhaled cockroach antigen after PVM infection when compared to wild-type mice. PMID: 27400340
10. The study demonstrate a protective role of IL-12Rbeta2 in relapsing-remitting experimental autoimmune encephalomyelitis. PMID: 26857496
11. Interleukin-12/23p40 plays an essential role in the development of graft-versus-host disease in mice. PMID: 25846718
12. Data indicate that sera from treated with cholesterol-p40 (Il12b)-siRNA contained significantly reduced concentrations of p40. PMID: 26232431
13. this study demonstrates viral RNA analog-induced transcription synergy of Il6 and Il12b via IFN regulatory factor (IRF)1 (TLR3-TIR domain-containing adaptor inducing IFN-beta [TRIF] responsive), C/EBPbeta (TLR7-MyD88 responsive), and JunB (all responsive). PMID: 26109639
14. our results suggest that IL-12p40 acts as a negative regulator of autoimmune cholangitis in IL-2Ralpha-/- mice. Compared to IL-2Ralpha-/- mice, p40-/-IL-2Ralpha-/- mice develop liver fibrosis and reduced colitis. PMID: 24651036
15. These results imply that a soluble host or Toxoplasma gondii factor is responsible for the bulk of IL-12p40 production in vivo. PMID: 25024368
16. the assembled p40-CD5L heterodimer does not recapitulate the biological activity of IL-12. PMID: 24821971
17. The immune-enhancing effect of the Cronobacter sakazakii ES2 phage results in the activation of nuclear factor-kappaB and dendritic cell maturation via the activation of IL-12p40 in the mouse bone marrow. PMID: 24184907
18. IL-12 does not induce the expression of IL-7 in microglia and macrophages via both IL-12Rbeta2 and IL-12Rbeta1. PMID: 24224652
19. Data indicate that the GCN2 knockout mice showed reduced inflammatory responses, with decreased IL-6 and IL-12 expression correlating with significant reduction in animal mortality. PMID: 24248597
20. IL-12p40 contributed most in inducing Th1 and Th17 polarization PMID: 23697689
21. IL-12p40 deficiency leads to uncontrolled Trypanosoma cruzi dissemination in the spinal cord resulting in neuronal death and motor dysfunction. PMID: 23152844
22. Klf10 is a transcription factor that regulates the expression of IL-12p40 in bone marrow-derived macrophages. PMID: 23065757
23. IL-18 and IL-12 exert a synergistic effect on the lungs by inducing MMPs, cathepsins S, and pro-inflammatory cytokines, which may promote pulmonary emphysema and inflammation. PMID: 22908875
24. Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline. PMID: 23178247
25. Novel IL27p28/IL12p40 cytokine suppressed experimental autoimmune uveitis by inhibiting autoreactive Th1/Th17 cells and promoting expansion of regulatory T cells. PMID: 22936807
26. TLR2 plays a dual role in regulating TLR9-dependent IL-12p40 production in dendritic cells. PMID: 22635254
27. in mice deficient in IL-12p40, human metapneumovirus infection induced an exacerbated pulmonary inflammatory response and mucus production, altered cytokine response, and decreased lung function PMID: 22606349
28. reactive oxygen species are important for IL-12 production induced by lactobacillus PMID: 22536449
29. MKP-1 increases the expression of IL-12 by enhancing the expression of IRF1 PMID: 22464096
30. extracellular signal regulated kinases modulate IL-12 expression by regulating IkappaB-zeta-dependent binding of NF-kappaB transcription factors to IL-12b gene promoter PMID: 22131231
31. Francisella tularensis LVS induced innate production of IL-12p(40)2 is required for dendritic cell migration. PMID: 21669537
32. microbiota negatively regulates host miR-10a expression, which may contribute to the maintenance of intestinal homeostasis by targeting IL-12/IL-23p40 expression. PMID: 22068236
33. Data show that the p40 vaccine induced specific antibodies to IL-12 and IL-23, which was associated with improvement of intestinal inflammation and fibrosis. PMID: 21424108
34. dendrittic cells-derived, controls acute infection by Toxoplasma gondii PMID: 21867928
35. MW and glucocorticoids independently modulate IL-12p40 production through a mechanism involving ERK1/2 hyperactivation and that glucocorticoids can significantly augment MW-induced inhibition of IL-12p40. PMID: 21730055
36. A distal enhancer in Il12b is the target of transcriptional repression by the STAT3 pathway and requires the basic leucine zipper (B-ZIP) protein NFIL3. PMID: 21566115
37. Data identified NFIL3 as a regulatory transcription factor in macrophages, controlling IL-12 p40 production. PMID: 21383239
38. The colitis-prone SJL/J-derived polymorphic variant of IL12b p40 more readily forms p70 heterodimers than does the colitis-resistant C57BL/6 strain-derived p40 variant. PMID: 21321105
39. PKCdelta is a regulator of IL-12p40/p70 production by dendritic cells and macrophages, driving the healer phenotype during cutaneous leishmaniasis. PMID: 21287553
40. macrophage-derived Arg I protects hosts against excessive tissue injury caused by worm eggs during acute schistosomiasis by suppressing IL-12/IL-23p40 PMID: 20483789
41. CD14(neg) B6 mice showed delayed production of IL12p40 in response to necrotic cells PMID: 19840871
42. These studies demonstrated that IL-12 plays a predominant role in the expansion of effector CD8(+) T-cell immunity against Encephalitozoon cuniculi, which is critical for host survival. PMID: 20308292
43. there is a critical role for the tyrosine phosphatase activity of SHP-1 for induction of IL-12p40 production in macrophages in response to TLR ligands PMID: 20145200
44. Results show that IL-12-->IL-27 sequential gene therapy provides a simple but effective approach for eliminating inaccessible residual tumors. PMID: 20139275
45. IL-12p40 induction in macrophages is directly regulated by the intracellular glutathione-redox status of mouse macrophages in vitro. PMID: 20164428
46. We suggest that overproduction of NO may account for neuronal death at the spinal cord of T. cruzi-infected IL-12p40KO mice and that IFN-gamma and S100beta may contribute to NOS activation in the absence of IL-12. PMID: 19923851
47. We found that the production of IL-12 preceded that of other cytokines in response to Influenza A virus lung infection. PMID: 19941386
48. Langerin-positive cells are not required for initial activation of invariant natural killer T (iNKT) cells, but are required for downstream release of large quantities of IL-12p70 into the serum. PMID: 19923446
49. protective and agonistic function in mycobacterial infection PMID: 11739515
50. Heat shock inhibits IL-12 p40 expression through NF-kappa B signalling pathway in murine macrophages PMID: 11792125

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KEGG: mmu:16160

STRING: 10090.ENSMUSP00000099860

UniGene: Mm.239707