Recombinant Mouse Leucine-rich repeat-containing G-protein coupled receptor 4 (Lgr4), partial

1. he HA tag-specific antibody can be employed to characterize the biochemical features of Lgr4 and to identify possible biding partners of the protein in cells derived from various mouse tissues. PMID: 28634819
2. LGR4 might play a vital role in stem cells from apical papillae proliferation and odontoblastic differentiation. PMID: 28986711
3. compressive force induced the differentiation of RAW264.7 from increase in RANK and decrease in LGR4 expression. PMID: 29572179
4. the host protein leucine-rich repeat-containing G protein-coupled receptor 4 (Lgr4) is essential for VSV and VSV-G pseudotyped lentivirus (VSVG-LV) to infect susceptible cells. PMID: 28842478
5. Data (including data from studies using transgenic/knockout mice) suggest that LGR4 is key protein necessary for prostate cancer epithelial-mesenchymal transition and metastasis; LGR4 expression is elevated in human prostate cancer cell lines with metastatic potential; LGR4 silencing in prostate cancer cell line impairs cell migration and invasion without affecting cell proliferation. PMID: 28768769
6. LGR4 is another receptor for RANKL. LGR4 competes with RANK to bind RANKL and suppresses canonical RANK signaling during osteoclast differentiation. Both whole-body (Lgr4(-/-)) and monocyte conditional knockout mice of Lgr4 (Lgr4 CKO) exhibit osteoclast hyperactivation (including elevation of osteoclast number, surface area, and size) and increased bone erosion. PMID: 27064449
7. Lgr4 is a critical positive factor for skin tumorigenesis by mediating the activation of MEK1/ERK1/2 and Wnt/beta-catenin pathways. PMID: 27693558
8. RSPO-LGR4/5-ZNRF3/RNF43 module controls metabolic liver zonation and is a hepatic growth/size rheostat during development, homeostasis and regeneration. PMID: 27088858
9. These date indicate that hydrogen peroxide suppresses Lgr4 expression in osteoblastic cells. PMID: 27861872
10. Lgr4 gene is regulated by BMP and is required for BMP effects on osteoblastic differentiation. PMID: 26332449
11. Rspo1 and its receptor of leucine-rich repeat containing G-protein-coupled receptor 4 (Lgr4) should be a novel molecular signal in the transmission of mechanical stimuli to biological signal in the bone, and this signal should be in the upstream of Wnt/beta-catenin signaling for bone formation. PMID: 28272338
12. Study suggests that miR-34c contributes to osteoclast differentiation by targeting LGR4, providing novel insights into understanding the molecular mechanism underlying osteoclast differentiation. PMID: 28130056
13. A mechanistic understanding of RANKL-LGR4 interaction has provided new insight into LGR4 mediated RANKL signaling in osteoporosis and other diseases PMID: 27178473
14. LGR4 acted as a key receptor for Rspo2 to promote osteogenesis. PMID: 27140682
15. Lgr4 is critical for ovarian somatic cell specialization via the cooperative signaling of Rspo1 and Wnt/beta-catenin PMID: 26333992
16. results suggest that the deletion of Lgr4 can lead to premature cataract formation, as well as progressive deterioration with aging. PMID: 25811370
17. The endogenously expressed Lgr4 may act as an antagonist molecule that helps to fine-tune the R-spondin/norrin-mediated Lgr4-Wnt signaling during gonadal development. PMID: 25188337
18. suggests that Lgr4 might serve as an adaptive regulator between glucose and lipid metabolism in skeletal muscle and reveals a potentially new regulator for a well-established adaptive network PMID: 26102032
19. An important role for Lgr4 in motor coordination and cerebellar synaptic plasticity. PMID: 25063812
20. formation of polycystic lesions and renal fibrosis induced by Gpr48 deficiency involves the activation of Wnt signaling pathway but not the TGF-beta/Smad pathway PMID: 24595031
21. The members of the R-spondin family are known as activators of Wnt signaling, and Lgr4, Lgr5, and Lgr6 have been identified as receptors for R-spondins. PMID: 24616052
22. Lgr4 regulates corpus luteum maturation through modulation of the WNT-mediated EGFR-ERK signaling pathway. PMID: 24877628
23. LGR4 plays an important role in the regulation of plasma lipid rhythms, partially through regulating the expression of microsomal triglyceride transfer protein; these data provide a possible link between the peripheral circadian clock and lipid metabolism PMID: 24353284
24. data revealed the roles of Lgr4 in early prostate development and in stem cell differentiation through regulation of the Wnt, Notch, and Sonic Hedgehog signaling pathways. PMID: 23897697
25. Lgr4KO and Lgr4/5KO results in complete loss of intestinal stem cells in embryos, impairs proliferation of developing kidney and skin epithelium, and depletes Lgr5+follicular epithelium and impairs hair follicle development. PMID: 24680895
26. Lgr4, which regulates eye, kidney, testis, ovary, and uterine organ development as well as mental development through genetic and epigenetic surveillance, is a novel candidate gene for the pathogenesis of AGR syndrome PMID: 24519938
27. Lgr4 activates Sox2 to regulate mammary development and stem cell functions via Wnt/beta-catenin/Lef1. PMID: 23712846
28. identify the transforming growth factor beta antagonist follistatin as a key mediator of RSPO-LGR4 signaling in myogenic differentiation PMID: 24344199
29. LGR4 has a critical role in uterine gland morphogenesis through amplifying Wnt-beta-catenin signaling PMID: 23975934
30. Multi-functional norrin is a ligand for the LGR4 receptor. PMID: 23444378
31. Lgr4/Gpr48 plays a critical role in modulating the TLR2/4 signaling pathway and represents a useful therapeutic approach of targeting Lgr4/Gpr48 in TLR2/4-associated septic shock and autoimmune diseases. PMID: 23589304
32. Lgr4 signaling through Wnt/beta-catenin regulates peritubular myoid cells and is essential for spermatogenesis. PMID: 23533175
33. Lgr4 is critically involved in the maintenance of intestinal homeostasis and protection against inflammatory bowel disease through modulation of the Wnt/beta-catenin signaling pathway PMID: 23393138
34. LGR4 is required for cell survival of the peripheral mesenchyme at the embryonic stages of nephrogenesis. PMID: 22738954
35. GPR48 enhances aldosterone responsiveness by activating mineralocorticoid receptor expression. PMID: 22135314
36. Lgr4 has a novel function for maintaining the ureteric bud in an undifferentiated state. PMID: 21523854
37. Our results identify LGR4 as a permissive factor in the Wnt pathway in the intestine PMID: 21508962
38. Relationship between the functions of Lgr4 and female reproductive systems. PMID: 20638054
39. GPR48 is one of the constituents responsible for the EGFR signaling pathway with its effects directly linked to its ligand, HB-EGF. PMID: 20732323
40. Gpr48 participates in the development of the male epididymis and efferent ducts through regulation of ERalpha expression via the cAMP/PKA signaling pathway. PMID: 20023170
41. LGR4 is an important signaling molecule implicated in the tube morphogenesis of the male reproductive tract PMID: 16406039
42. Lgr4 has pivotal roles to play in the regulation of ESR1 expression, the control of duct elongation through basement membrane remodeling, and the regional differentiation of the caput epididymidis. PMID: 17079737
43. Lgr4 might be a novel gene class regulating cell motility PMID: 17850793
44. Disruption of Gpr48 causes anterior segment dysgenesis through down-regulation of the Pitx2 gene. PMID: 18424556
45. Inactivation of GPR48 induces the EOB phenotype by reducing epithelial cell proliferation and migration, indicating that GPR48 plays an essential role in eyelid development. PMID: 18487371
46. Lgr4 might be a novel gene class regulating the development of hair follicles PMID: 18651655
47. Gpr48/Lgr4 inactivation impairs definitive erythropoiesis at midgestation through down-regulation of the ATF4 signaling pathway PMID: 18955481
48. Although Lgr4 hypomorphic mutant (Lgr4(Gt/Gt)) embryos developed a normal gall bladder bud at embryonic day (E) 10.25, no further elongation was observed at later stages PMID: 19301403
49. Data demonstrate that Gpr48 regulates bone formation and remodeling through the cAMP-PKA-Atf4 signaling pathway. PMID: 19605502

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KEGG: mmu:107515

STRING: 10090.ENSMUSP00000047325

UniGene: Mm.277351