Recombinant Mouse Multidrug resistance-associated protein 1 (Abcc1), partial

1. The authors conclude that MRP1 assists in depression of polymorphonuclear cell (PMN) migration by effluxing a molecule that inhibits the proinflammatory effects of MRP2 activity. PMID: 29976647
2. Mrp1 protects cardiac myocytes and fibroblasts against doxorubicin-induced toxicity, potentially by regulating extracellular redox states. PMID: 26822305
3. Loss of ABCC1 expression is associated with neonatal hyperbilirubinemia. PMID: 28025333
4. Data, including data from studies in knockout mice, suggest that Mrp1 is involved in development of vascular endothelial dysfunction in diabetic angiopathy; Mrp1 appears to be required for oxidative stress in endothelial cells due to hyperglycemia. PMID: 26908299
5. Oxidant-enriched Tumorigenic Endothelial Cells (EOMA) cells survive a heavy oxidant burden by rapid efflux of GSSG, which is lethal if trapped within the cell. A hyperactive MRP-1 system for GSSG efflux acts as a critical survival factor for these cells, making it a potential target for EOMA therapeutics. PMID: 26961872
6. P-gp, Bcrp, Mrp1 and Mrp4 are differentially expressed at the outer and inner blood retinal barrier, resulting in an altered ability to limit substrate distribution at the retina as compared with the blood brain barrier PMID: 26507673
7. Lentivirus-based RNAi stably knocks down the expression of the Mrp1 gene in the established TM4 sertoli cell line. PMID: 25403683
8. neprilysin x ABCC1 double-deficient mice present a new model for early effects of amyloid-beta-related mild cognitive impairment that allows investigations without artificial overexpression of inherited Alzheimer's disease genes PMID: 25991605
9. Expression of apoA-I or ABCA1 can reduce steatosis by decreasing lipid storage in hepatocytes through lipid transport and may also reduce endoplasmic reticulum stress, further lessening hepatic steatosis PMID: 24219083
10. Loss of Mrp1 coupled with reductions in steroid hormone levels leads to alterations in extrahepatic phase I, phase II and phase III metabolizing enzymes in a tissue-specific manner. PMID: 22522787
11. Cd or H(2)O(2) exposure increased the expression of key transport genes, Mrp1 and Mrp2, in WT cells but not in metallothionein-null cells. PMID: 22914987
12. These results identify Mrp1 as the transporter essential for S1P efflux from the endothelial cells and thus for inside-out S1P signaling to P-glycoprotein at the blood-brain and blood-spinal cord barriers. PMID: 23168528
13. investigated changes in the expression and activity of multidrug resistance protein 1 and multidrug resistance-associated protein 1 in highly purified lung dendritic cells during aging PMID: 22451472
14. Data suggest glutathione offers neuroprotection against methylmercury toxicity in a manner dependent on MRP1-mediated efflux. PMID: 22464990
15. Results show that the presence of Mdr1a, Mdr1b (P-glycoprotein Pgp) and multidrug resistance-associated protein (MRP1) encoding genes in the olfactory mucosa of rat and mouse was confirmed by RT-PCR. PMID: 22563480
16. Assessment of activity, exploratory behavior, and anxiety levels revealed behavioral alterations in Abcb1(0/0) and Abcc1 (0/0) mice, whereas Abcg2(0/0) mice were mostly unaffected. PMID: 22545122
17. Apolipoprotein-E controls adenosine triphosphate-binding cassette transporters ABCB1 and ABCC1 on cerebral microvessels after methamphetamine intoxication.( PMID: 22426312
18. MRP1 and alpha crystallin are potential therapeutic targets in pathological retinal degenerative disorders linked to oxidative stress. PMID: 22442691
19. DNIC storage function of GST P1-1 and ability of MRP1 to efflux DNICs are vital in protection against NO cytotoxicity PMID: 22084240
20. the transporter ABCC1 has an important role in cerebral amyloid-beta clearance and accumulation PMID: 21881209
21. MDR1 and MRP1 in LDCs may be involved in protective functions through their efflux activities. PMID: 21763326
22. This study showed that nearly complete oxidation of free cholesterol in the plasma membrane of MRP1-expressing baby hamster kidney cells did not affect MRP1 localization in lipid rafts or its efflux function. PMID: 21609321
23. Treatment of macrophages with LPS resulted in 2-fold increases of MRP-1 expression or functional activity PMID: 19894120
24. cortical actin disruption results in reduced Mrp1/MRP1 (Abcc1/ABCC1) activity concomitant with a partial shift of Mrp1/MRP1 (Abcc1/ABCC1) out of lipid raft fractions and partial internalization of the ABC transporter PMID: 21045108
25. Results indicate that Mrp1-/- mice have lowered steroid hormones levels, and suggests that upregulation of steroid biosynthetic enzymes may be an attempt to maintain proper steroid hormone homeostasis. PMID: 20178799
26. Identification of multidrug resistance protein 1 (MRP1/ABCC1) as a molecular gate for cellular export of cobalamin. PMID: 19897579
27. LTC(4) stimulation results in a significant activation of MRP1, but does not alter MRP1 expression PMID: 19685171
28. polyclonal antibodies recognizing both human and rodent MRP1 PMID: 11689020
29. Mice lacking mrp1 have significantly increased hepatic transcription of at least two other ATP-binding cassette transporters PMID: 14742140
30. Mrp1 was rather expressed than P-gp in parenchyma astrocytes and in glia limitans lining the meninges. PMID: 15328029
31. Mrp1 limits intracellular accumulation of unconjugated bilirubin and thus decreases its cytotoxicity. PMID: 16458308
32. IFN-gamma can protect against NaAs-induced acute renal injury, probably by maintaining Nrf2-mediated intrarenal MRP1 gene expression. PMID: 17003472
33. The effects of lipopolysaccharides on ABCC1 transporters in RAW macrophages and inhibitors of these transporters were capable of inhibiting nitrite production suggesting a role for ABCC1 transporters in the inflammatory process. PMID: 17169333
34. Mrp1 triple knock-out mice lacking the genes for Mrp1 and Mdr1a/1b are more susceptible to developing features of chronic obstructive pulmonary disease (COPD) than their wild-type littermates. PMID: 17617921
35. Abcc6/1(-/-) double knock-out mice exhibited connective tissue mineralization similar to that in Abcc6 (-/-) mice. PMID: 17845218
36. MRP1 plays an important role in the development of allergic airway inflammation through regulation of IgE-mediated cysteinyl-leukotriene export from mast cells PMID: 18931056

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KEGG: mmu:17250

STRING: 10090.ENSMUSP00000097743

UniGene: Mm.196634