Recombinant Mouse P2Y purinoceptor 12 (P2ry12), partial

1. OC formation was efficiently restored by addition of adenosine diphosphate, a P2Y12 agonist, as well as by addition of CysLT. Furthermore, similar to montelukast, P2Y12 blockade by a pharmacological inhibitor or siRNAs suppressed OC differentiation PMID: 29916540
2. Our finding demonstrated that genetic deletion of P2Y12 receptor broke the balance of Th subtypes by affecting the cytokine profile of bone marrow-derived dendritic cells and resulted in the aggravated experimental autoimmune encephalomyelitis, which suggested that P2Y12 may be a potential target in treating multiple sclerosis. PMID: 27939246
3. Study demonstrates a complementary role between TSSC6 and P2Y12 receptor in platelets in regulating 'outside in' integrin alphaIIbbeta3 signalling thrombus growth and stability. PMID: 29178985
4. Findings offer insight into positive regulation of Akt signaling through P2Y12 phosphorylation as well as MAPK signaling in platelets by ASK1. PMID: 28753204
5. CLEC-2 and P2Y12 are required for CpG ODN-induced platelet activation and thrombosis, and might be targeted to prevent adverse events in patients at risk. PMID: 28296036
6. Nucleotide transmitters ATP and ADP mediate intercellular calcium wave communication via P2Y12/P2Y13 receptors among BV-2 microglia. PMID: 28800362
7. findings not only revealed the critical role of P2Y12 in Th17 differentiation and EAE pathogenesis, but also suggested the promising potential of P2Y12 antagonists in the treatment of autoimmune diseases PMID: 28515278
8. P2y12 Receptor Promotes Pressure Overload-Induced Cardiac Remodeling via Platelet-Driven Inflammation in Mice. PMID: 28827474
9. In P2Y12(-/-) mice, the growth of syngeneic ovarian cancer tumors was reduced by >85% compared with wild-type (WT) mice. In contrast, there was no difference in tumor growth between P2Y1(-/-) and WT mice. PMID: 28679740
10. Vessel wall P2Y12 receptor, which promotes VSMCs migration through cofilin dephosphorylation, plays a critical role in the development of atherosclerotic lesions. PMID: 28062501
11. P2Y12 null mice are refractory to sepsis-induced lung injury, suggesting a key role for activated platelets and the P2Y12 receptor during sepsis. PMID: 27055904
12. excessive mechanical stress may induce a sustained release of ADP and promote SMC senescence via P2ry12-dependent sustained Ras activation, thereby contributing to excessive inflammation and degeneration, which provides insights into TAAD formation and progression. PMID: 27534720
13. AHR and airway inflammation in a mouse model of asthma. P2Y12 can be a novel therapeutic target to the suppression of eosinophils in asthma. PMID: 26612496
14. quinine/bupivacaine-sensitive potassium channels are the functional effectors of the P2Y12R-mediated signaling in microglia activation following neuronal injury PMID: 26791526
15. Calcium-mediated purinergic receptors regulate the migration and phagocytic ability of microglia during post-natal brain development. PMID: 25575683
16. Disrupting P2Y12 alters the microglial response to monocular deprivation and abrogates ocular dominance plasticity. PMID: 26948129
17. P2RY12-mediated activation of juxtavascular microglial cells contributes to the rapid closure of small openings in the BBB. PMID: 26755608
18. study reports robust involvement of P2Y12R in inflammatory pain: anti-hyperalgesic effect of P2Y12R antagonism could be mediated by the inhibition of both central and peripheral cytokine production and involves alpha7-receptor mediated efferent pathways PMID: 24971933
19. demonstrating that these P2Y12 inhibitors may not be effective in preventing early disease PMID: 24510394
20. indicate that P2Y12R undergoes slow desensitization; ADP-P2Y12 signaling is tightly regulated by Entpd1/Nt5e activity and adenosine receptors PMID: 25208846
21. P2Y12 signaling is required for stabilizing platelet thrombi. PMID: 24477045
22. Platelet P2Y12 is involved in murine pulmonary metastasis. PMID: 24236201
23. The P2Y12 receptor plays an important role during lipopolysaccharide-induced inflammation. PMID: 24142066
24. P2Y12 participates in ischemia related inflammation by mediating microglial migration and potentiation of neurotoxicity. PMID: 23940669
25. This study demonistrated that environment enhanced P2Y12 expression in brain and enhanced totaroad perfermance and short term working menory. PMID: 23558143
26. Epac agonist 8-pCPT-2'-O-Me-cAMP affects P2Y12 receptors in blood platelets PMID: 23850619
27. Demonstrate that P2Y(12) activation protects platelets from apoptosis via PI3k-dependent Bak/Bax inactivation. PMID: 23140172
28. P2RY12 is the primary ADP receptor in osteoclasts. In vivo, P2ry12-/- mice were partially protected from pathologic bone loss, as were those with clopidogrel-induced inhibition of P2ry12. PMID: 22996695
29. P2Y12 modulates atherogenesis, at least in part by augmenting inflammatory cell recruitment via regulation of platelet alpha-granule release. PMID: 22628428
30. beta-arr1 has a role in promoting thrombus formation, in part through its participation in alphaIIbbeta3 signalling, but neither beta-arr1 or beta-arr2 have a role in agonist-induced platelet activation and P2Y receptors desensitisation PMID: 22318609
31. Real-time imaging reveals that P2Y2 and P2Y12 receptor agonists are not chemoattractants and macrophage chemotaxis to complement C5a is phosphatidylinositol 3-kinase (PI3K)- and p38 mitogen-activated protein kinase (MAPK)-independent. PMID: 22199395
32. P2Y2 and P2Y12 receptor agonists are not chemoattractants and macrophage chemotaxis to complement C5a is phosphatidylinositol 3-kinase (PI3K)- and p38 mitogen-activated protein kinase (MAPK)-independent. PMID: 22057273
33. P2Y12-mediated migration of host-derived smooth muscle-like cells and CD45+ leukocytes may play an important role in the development of transplant arteriosclerosis, partly by MCP-1 pathways. PMID: 21629176
34. data revealed that the P2Y12 receptor pathway was substantially involved in platelet hyperreactivity associated with mild and severe hypercholesterolemia PMID: 21261805
35. Platelet P2Y(12) receptors play a crucial role in the stabilization of thrombi formed on atherosclerotic plaques. This P2Y(12) function is restricted to high shear flow conditions, and is preserved in the presence of coagulation. PMID: 20405028
36. Studies indicate that CalDAG-GEFI mediates the rapid but reversible activation of integrin alphaIIbbeta3, and the adenosine diphosphate receptor P2Y12 facilitates delayed but sustained integrin activation PMID: 20971951
37. Exposure to smoke heightens platelet reactivity and thrombosis in Apoe-/- mice and implicate signaling through platelet P2Y12 receptor as a mediator of the adverse consequence of smoke exposure. PMID: 20451958
38. Ticagrelor effectively and reversibly inhibits P2Y(12)-mediated platelet function and thrombosis in mice. P2Y(12) inhibition is required both at the time of and after injury to effectively inhibit neointima formation. PMID: 21071697
39. Data show that autocrine purinergic receptor P2Y(2), or P2Y(12) signaling amplifies and translates chemotactic cues into directional motility. PMID: 20664064
40. P2ry12 signaling was more important than PAR signaling in hemostasis models; the converse was noted for arterial thrombosis models. PMID: 20930120
41. Data detected mRNA and protein for ADP receptors P2Y12 and P2Y13 in mouse dorsal root ganglia (DRG). P2Y14, a homologous Gi-coupled nucleotide receptor, is also expressed in DRG. PMID: 20398327
42. role of P2Y12 in platelet thrombosis and how its complete absence affects the thrombotic process PMID: 12897207
43. Results describe the cloning of DNA sequences encoding the murine ortholog of the human P2Y12 receptor, and its expression in the mouse brain. PMID: 15464998
44. secreted ADP strongly potentiated Rac activation induced by FcgammaRIIa clustering or TRAP via its P2Y12 receptor PMID: 16194206
45. P2Y(12) is a primary site at which nucleotides act to induce microglial chemotaxis at early stages of the response to local CNS injury. PMID: 17115040
46. the combined catalytic and non-catalytic signaling function of p110 beta and p110 gamma is critical for P2Y(12)/G(i)-dependent integrin alpha(IIb)beta(3) regulation. PMID: 17673465
47. These results clearly provide additional in vivo evidence that prasugrel has selective P2Y(12) antagonistic activity. PMID: 17681285
48. Activation of P2Y(12)Rs in spinal microglia may be critical event in pathogenesis of neuropathic pain. Blocking microglial P2Y(12)R might be viable therapeutic strategy for treating neuropathic pain. PMID: 18463248
49. role for platelet P2Y(12) in the vessel wall response to arterial injury and thrombosis PMID: 19103996
50. identified a molecular pathway in microglia that converted ATP-driven process extension into process retraction during inflammation: reversal was driven by upregulation of the A(2A) adenosine receptor coincident with P2Y(12) downregulation. PMID: 19525944

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KEGG: mmu:70839

STRING: 10090.ENSMUSP00000051353

UniGene: Mm.422675