P2RY12

P2RY12, also known as purinergic receptor P2Y12, has alternative names including HORK3, P2Y12, ADPG-R, BDPLT8, and SP1999. P2RY12 activates Gi protein by binding to ADP, thereby inhibiting adenylate cyclase (AC) and reducing the production of cyclic adenosine monophosphate (cAMP), which affects platelet aggregation and thrombosis. P2RY12 plays a crucial role in platelet activation and blood clotting, making it a potential target for treating thromboembolism and other coagulation disorders. Mutations in this gene are associated with platelet-type bleeding disorders, and alternative splicing leads to multiple transcript variants of the gene.