Recombinant Mouse Toll-like receptor 9 (Tlr9), partial

1. Microglial glucocorticoid receptors regulate TLR9 trafficking and lysosomal environment. Loss of glucocorticoid receptors enables activation of a microglial TLR9 inflammatory pathway, which can play a role in the progression of Parksinson disease. PMID: 29934589
2. TLR9 activation is augmented by short single-stranded DNA degradation products PMID: 28530246
3. Study shows that placental and/or fetal DNA stimulates toll-like receptor 9 (TLR9) leading to secretion of pro-inflammatory cytokines by macrophage cells. PMID: 28884630
4. Plasmodium DNA induces autoreactive responses against erythrocytes by activating a population of B cells expressing CD11c and the transcription factor T-bet, which become major producers of autoantibodies that promote malarial anaemia. PMID: 29101363
5. Our findings suggested the collaboration of TLR2-TLR9 at least in the regulation of SARM expression. PMID: 28889202
6. High cholesterol intake exacerbated acetaminophen-induced acute liver injury via the accumulation of free cholesterol in the endolysosomes of liver sinusoidal endothelial cells. This accumulation enhanced Toll-like receptor 9 signaling via impairment of its membrane trafficking mechanism. PMID: 28554874
7. these data provide a previously uncharacterized in vivo mechanism contingent on oligodeoxy-nucleotide -administered dose, where TLR9 governs the primary response and RAGE plays a distinct and cooperative function in providing a pivotal role in balancing the immune response. PMID: 28605247
8. this study shows that CD205-TLR9-IL-12 axis contributes to CpG-induced oversensitive liver injury in Hepatitis B viral antigens transgenic mice by promoting the interaction of NKT cells with Kupffer cells PMID: 27041637
9. The findings support a salutary role of TLR9 in some subsets of HF conditions and underline the importance for future studies on the mechanisms of TLR9 in diastolic HF. PMID: 28490840
10. TLR9-driven inflammation induced a Ccr2-independent expansion of functionally enhanced extramedullary myeloid progenitors that correlated with the peripheral accumulation of monocytes in both wild-type and Ccr2(-/-) mice. PMID: 27621476
11. TLR9 expression on B1a cells is not critical for their IgM-dependent atheroprotection. PMID: 27930350
12. This study establishes a correlation between TLR-3 and TLR-9 expression with the development of EAE. In addition, evidence of a role for the myelin peptide in targeting the innate inflammatory response to the CNS is presented. PMID: 26911613
13. these data demonstrate that TLR7/TLR9 ligands push the macrophage into a phagocytic long-lived cell, with a decreased capacity of antigen presentation and reminiscent of the M2 polarized state. PMID: 26567289
14. TLR9/MyD88 signaling selectively in CD11c(+) dendritic cells (DCs) strongly enhances murine cytomegalovirus clearance. PMID: 27760315
15. Overall, the data reveal that the early recruited sTLR9(+) neutrophils may, at least in the area of local inflammation, play a protective role during SIRS development and provide a method to rescue the patients with severe SIRS via the up-regulation of sTLR9 levels on the surface of neutrophils or via adoptive therapy with protective sub-populations of neutrophils. PMID: 28704709
16. High-glucose induces tau hyperphosphorylation through activation of TLR9-P38 MAPK pathway. PMID: 28803064
17. proposed that TLR9 regulates the NF-kappaB-NLRP3-IL-1beta pathway negatively in Salmonella-induced NKG2D-mediated intestinal inflammation and plays a critical role in defense against S. typhimurium infection and in the protection of intestinal integrity. PMID: 28576980
18. mechanism integrating BCR, TLR9, and cytokine signals provides a peripheral checkpoint for DNA-containing antigens that, if circumvented by survival and differentiative cues, yields B cells with the autoimmune-associated T-bet+ phenotype. PMID: 28346226
19. we demonstrated for the first time that the cross-talk of TLR2 and TLR9 triggered Th1 activation collaboratively PMID: 27693915
20. the cooperative role of TLR9 with TLR2 or TLR6 receptors in sensing Brucella, was determined. PMID: 26578650
21. accelerating effects of Tlr9 deficiency PMID: 28278279
22. Increased circulating mtDNA combined with upregulated TLR9 expression may corporately play a role in EAM as well as TLR4 activation mediated cardiac inflammation and injury PMID: 28618428
23. Data show that inoculating mice deficient in toll-like receptors TLR4 or TLR9 with LPS or CpG-stimulated eosinophils, NK cell recruitment was observed alongside cytotoxicity. PMID: 28426135
24. Significantly lower levels of interferon-stimulated gene expression in response to purified curli-DNA in TLR2 and TLR9 deficient mice compared to wild-type mice. PMID: 28410407
25. these data provide a new perspective on the complexity of TLR9 regulation by proteolytic cleavage PMID: 27421483
26. platelet response to S. pneumoniae and a role for TLRs, is reported. PMID: 27253707
27. Mechanical ventilation does not result in the release of mtDNA, and TLR9 is not involved in mechanical ventilation-induced inflammation PMID: 28099322
28. this study shows that human beta-defensin 3 amplifies the response to bacterial DNA in immune cells in a TLR9-dependent manner PMID: 28102569
29. The mRNA expression of TLR4 and NF-kappaB is decreased in a neonatal murine model of necrotizing enterocolitis. PMID: 27357505
30. Although the TLR9 signaling pathway is not involved in the acute inflammatory response in infarct hearts, it ameliorates cardiac rupture possibly by promoting proliferation and differentiation of cardiac fibroblasts. PMID: 27769998
31. loss of Tlr9 selectively augments the intensity of IL-17-driven immune responses to H. pylori in a cag T4SS-dependent manner. PMID: 27758771
32. functional Tlr9 signaling in neutrophils, is an important mechanism in early stasis experimental venous thrombogenesis. PMID: 26482993
33. this paper shows that endosomal retention of TLR9 via the interaction of IRAP with the actin cytoskeleton is a mechanism that prevents hyper-activation of TLR9 in dendritic cells PMID: 28319098
34. data demonstrated for the first time that NK cells directly recognize Baculovirus via TLR9, which provides opportunities for the use of this technique as an effective tool for Baculovirus-based immunotherapies against malignancies. PMID: 28186087
35. 3-Hydroxy-4,7-megastigmadien-9-one, isolated from Ulva pertusa, attenuates TLR9-mediated inflammatory response by down-regulating mitogen-activated protein kinase and NF-kappaB pathways. PMID: 27937044
36. Results demonstrate that nerve stimulation of TLR9 knock-out muscles produces weaker response than when the muscle is stimulated directly; TLR9 knock-out mice have functional and morphological alterations of the neuromuscular junction PMID: 26955780
37. Munc13-4 regulates endosome-initiated, TLR9-dependent signaling and TLR9-specific cellular functions in neutrophils. PMID: 26680738
38. TLR9 expression showed dynamic changes for a long period of time and microglias were the main brain cells to express TLR9 after cerebral ischemia and reperfusion. PMID: 26000727
39. These findings demonstrate differential reaction of cholinesterase-targeting miRNAs to distinct TLR9 challenges, indicating upstream miRNA co-regulation of the intestinal alternative NFkappaB pathway and cholinergic signaling. PMID: 26003847
40. critical for late venous thrombosis resolution; associated with necrosis clearance, but does not affect vein wall fibrosis PMID: 26179893
41. activated ARF3 is associated with Unc93B1 and TLR9, suggesting that ARF3 conducts TLR9 trafficking by forming the TLR9-Unc93B1-ARF3 complex. PMID: 26067373
42. In mice, nonalcoholic steatohepatitis development in response to a high-fat diet required TLR9 on lysozyme-expressing cells PMID: 26808498
43. TLR9 activation at high and low CpG ODN concentrations has roles in acute and chronic vascular injury in mice PMID: 26751387
44. The current study demonstrates for the first time an immunomodulatory role for TLR9 in acute kidney injury by enhancing the capacity of Tregs to migrate to damaged tissue in a model of common and relevant kidney disease. PMID: 26116356
45. recognition of beta-1,3 glucan by Dectin-1 triggers TLR9 trafficking to beta-1,3 glucan-containing phagosomes, which may be critical in coordinating innate antifungal defense. PMID: 26829985
46. protein deficiency protects female lupus-prone lupus like disease PMID: 26553076
47. Sustained activation of Toll-like receptor 9 causes cardiac and systemic inflammation, and deterioration of SERCA2a depletion-mediated diastolic heart failure. PMID: 26461521
48. TLR9 signaling is involved in regulating adipose tissue inflammation and controlling obesity and the metabolic syndrome. PMID: 26260403
49. Genetic deletion of MyD88, TLR2 or TLR9 effectively controlled the signs of intestinal injury when compared with irinotecan-administered WT controls PMID: 26440613
50. AP-3 recruitment to TLR9 endosomes was impaired by PIKfyve inhibition. PMID: 25925170

Show More

Hide All

KEGG: mmu:81897

STRING: 10090.ENSMUSP00000082207

UniGene: Mm.44889