Recombinant Mouse Tumor necrosis factor ligand superfamily member 13B (Tnfsf13b), partial

1. BAFF loop region controls B cell survival and regulates recognition by different inhibitors PMID: 29572442
2. Male mice lacking the androgen receptor have increased splenic B cell numbers, serum BAFF levels and splenic Baff mRNA. Testosterone deficiency by castration causes expansion of BAFF-producing fibroblastic reticular cells in spleen. PMID: 29802242
3. results indicate that the BAFF-BAFFR ligation bridged between microglia and neurons could play a critical neuroprotective role in brain ischemic injuries PMID: 28918255
4. Data presented show that B-cell activating factor (BAFF) plays a central role in the induction and maintenance of cigarette smoke-induced pulmonary antinuclear antibodies and suggest a therapeutic potential for BAFF blockade in limiting autoimmune processes associated with smoking. PMID: 28039405
5. This study suggests that BAFF selects IL-10(-)B cells over IL-10(+) regulatory B cells via BAFF receptors in inflammatory responses PMID: 28199852
6. BAFF plays a previously unappreciated role in lupus nephritis by inducing renal tertiary lymphoid structures and regulating the position of T cells within the glomeruli. PMID: 28235864
7. this study shows that BAFF overexpression reduces hypercholesterolemia and atherosclerosis in hyperlipidemic mice via TACI-dependent B cell activation PMID: 27837104
8. B cell-activating factor (BAFF) upregulates CD28/B7 and CD40/CD154 expression, and promotes the interactions between T and B cells in a BAFF receptor-dependent manner. PMID: 27180986
9. findings highlight a novel mechanism through which BAFF promotes humoral autoimmunity via direct, TACI-dependent activation of transitional B cells PMID: 27022196
10. neutrophils secreted a B cell-activating factor that highly accelerated plasma cell generation and antigen-specific antibody production. PMID: 27432941
11. The enhanced thermogenic program was confirmed by higher protein levels of UCP1 and irisin in female BAFF-/- than in WT mice. PMID: 27814392
12. Antibodies That Block or Activate Mouse B Cell Activating Factor of the Tumor Necrosis Factor (TNF) Family (BAFF), Respectively, Induce B Cell Depletion or B Cell Hyperplasia. PMID: 27451394
13. Increased B-cell activating factor (BAFF) induced B cell differentiation into germinal center (GC) B cells within the autoimmune target tissue. PMID: 27352977
14. The Tnfas13b in the hippocampus in the prefrontal cortex of the DBA/2 J strain were up-regulated. PMID: 25895500
15. early Ab responses contribute to the optimal formation of B cell memory through IgG-immune complexes and BAFF. PMID: 26621863
16. autoimmunity induced by excessive BAFF production requires B1b B cells and CD19 signaling. PMID: 26103922
17. Data show that production of autoantibodies in B cell-activating factor of the TNF family (BAFF) is dependent on tumor necrosis factor receptor superfamily, member 13b protein (TACI) expression by B cells. PMID: 26027434
18. Cigarette smoke may hinder early mucosal IgA responses in the lung during influenza virus infection through oxidative inhibition of BAFF, which might contribute to the increased incidence and severity of viral infections in smokers. PMID: 25849069
19. Antagonizing BAFF in cigarette smoke-exposed mice attenuates pulmonary inflammation and alveolar destruction. PMID: 26266827
20. the elevated presence of APRIL and BLyS in B cell-rich areas of chronically inflamed gingiva suggests that these cytokines may contribute to bone loss by promoting the survival and persistence of RANKL-expressing B cells/plasma cells. PMID: 26150532
21. B cell activating factor (BAFF) and a proliferation inducing ligand (APRIL) mediate CD40-independent help by memory CD4 T cells in transplantations. PMID: 25496308
22. BAFF knockout improves systemic inflammation via regulating adipose tissue distribution in high-fat diet-induced obesity. PMID: 25591987
23. Our data therefore support a role for BAFF in the establishment of pulmonary fibrosis and a crosstalk between IL-1beta, BAFF and IL-17A. PMID: 25441030
24. BAFF(anti-B-cell activating factor) blockade delayed antibody production and increased GAA activity within tissues with protection from anaphylaxis. Anti-BAFF also resolved antibody formation during an immune response. PMID: 25842186
25. Immunization of mice with a DNA vaccine encoding BAFF or APRIL multitrimers, together with interleukin 12 and membrane-bound HIV-1 Env gp140, induced neutralizing antibodies against tier 1 and tier 2 (vaccine strain) viruses. PMID: 25631080
26. This study offers a rationale for localized therapeutic BAFF inhibition in primary Sjogren's syndrome and represents a proof of concept of the interest of exon skipping in autoimmune diseases. PMID: 24304965
27. Blockade of IL-21 decreases BAFF levels, which modulates T-cell and B-cell responses via mTORC inhibition. PMID: 25246268
28. Nitric oxide produced by inflammatory monocytes and their derivative dendritic cell subsets plays an important role in regulating BAFF production and T cell-independent antibody responses. PMID: 24951820
29. BAFF controls neural cell survival through BAFF receptor. PMID: 23923031
30. IL-4 regulates Bim expression and promotes B cell maturation in synergy with BAFF conferring resistance to cell death at negative selection checkpoints. PMID: 24835393
31. B cells chronically exposed to high levels of BAFF were poised for rapid induction of aerobic glycolysis and metabolic reprogramming. PMID: 24616478
32. This study suggests that BAFF suppresses IL-15 expression in autoimmune diseases PMID: 24670802
33. Local BLyS production by T follicular cells mediates retention of high affinity B cells during affinity maturation. PMID: 24367004
34. Although we have found that TACI is dispensable for controlling B. hermsii infection, mice deficient in BAFFR or BAFF exhibit impairment in B. hermsii-specific IgM responses and clearance of bacteremia. PMID: 24218480
35. Addition of BAFF to plasmablasts in vitro rescued IgM secretion, suggesting that BAFF signaling can directly regulate secretory processes. PMID: 24082070
36. The ability of TACI-Fc to activate reverse signalling through BAFF and APRIL, was investigated. PMID: 23620746
37. BAFF decreases leptin and adiponectin expression, but increases the expression of proinflammatory adipokines monocyte chemotactic protein-1, interleukin-6 (IL-6), cyclooxygenase-2 (COX-2) and haptoglobin. PMID: 23306702
38. CD1d-restricted invariant NKT cell-derived BAFF and APRIL each contribute to survival of plasma cells induced by immunization. PMID: 23797666
39. Blockade of B-cell-activating factor signaling enhances hepatic steatosis induced by a high-fat diet and improves insulin sensitivity. PMID: 23318884
40. BAFF-overexpressing mice were protected from lethal malaria infections, indicating the significance of the role BAFF plays in determining the outcome of malaria infections. PMID: 22936176
41. Bcl10 controls BAFF-induced canonical NF-kB activation directly and noncanonical NF-kB activation indirectly determining the survival of anergic B cells. PMID: 23087406
42. Studies identify p202 as a regulator of murine BAFF. PMID: 22784990
43. BAFF-specific inhibitor AMG623 peptibody reduces B-cell number and improves outcomes in murine models of autoimmune disease. PMID: 22325420
44. Elimination of both APRIL and BAFF had no discernible effect on the development of renal immunopathology or clinical disease beyond that of elimination of BAFF alone. PMID: 22127792
45. Serum BAFF levels are elevated in RP105-deficient mice, and partial BAFF neutralization rescues aberrant B cell proliferative responses in such mice. PMID: 22291190
46. In vivo BLyS neutralization effectively induces humoral tolerance and promotes long-term islet allograft survival in mice. PMID: 22262127
47. BAFF-R expression is tightly regulated during B-cell development in mouse and human and this expression is correlated with positive selection. PMID: 22028296
48. Soluble BAFF levels inversely correlate with peripheral B cell numbers and the expression of BAFF receptors. PMID: 22124120
49. adipogenic differentiation may alter the immunoregulatory property of MSCs, leading to stimulation of lymphocytes response. The BAFF molecule secreted by the adi-MSCs was responsible for this event. PMID: 21902897
50. a contribution of BAFF to pathogenic Th17 cell responses PMID: 21897850

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KEGG: mmu:24099

STRING: 10090.ENSMUSP00000033892

UniGene: Mm.28835