TNFSF13B

TNFSF13B is a gene providing an instruction of making a protein named tumor necrosis factor ligand superfamily member 13B (also abbreviated as TNFSF13B). This protein is plays an important role in the proliferation and differentiation of B cells. It also influences antibody class switch. TNFSF13B is involved in the pathophysiology of pulmonary diseases.

TNFSF13B protein, also known as BAFF, is a cytokine that binds to TNFRSF13B (also called TACI), TNFRSF17 (also known as BCMA) and TNFRSF13C (also called BAFF-R). These receptors have differing binding affinities for BAFF and are expressed mainly on mature B lymphocytes, and their expression varies in dependence of B cell maturation. BAFF, acting via TACI, have a regulatory effect on antibody production. Interaction between BAFF and BCMA promotes B cell survival, maturation, and differentiation. Acting via BAFF-R, BAFF-BAFF-R activates classical and noncanonical NF-κB signaling pathways, triggering signals essential for the formation and maintenance of B cell, thus it is important for a B-cell survival.

Popular Products

● Recombinant Human Tumor necrosis factor ligand superfamily member 13B(TNFSF13B) ,partial (Active) (CSB-MP897523HU1)

Validated Data

Purity determined
by SDS-PAGE

Greater than 93% as determined by SDS-PAGE.

High TNFSF13B-TNFRSF13C Binding Bioactivity Validated by Functional ELISA

Immobilized TNFSF13B at 2 μg/ml can bind TNFRSF13C (CSB-MP853495HU1), the EC₅₀ is 9.943-15.72 ng/ml.

Excellent TNFSF13B-BCMA Binding Bioactivity Validated by LSPR

Human TNFSF13B protein Fc tag captured on COOH chip can bind Human BCMA protein Fc tag (CSB-MP023974HU1) with an affinity constant of 39 nM.

Excellent TNFSF13B-BCMA Binding Bioactivity Validated by Functional ELISA

Immobilized TNFSF13B at 10 μg/ml can bind human BCMA (CSB-MP023974HU1), the EC₅₀ of human TNFSF13B protein is 221.3-298.6 ng/ml.

● Recombinant Human Tumor necrosis factor ligand superfamily member 13B(TNFSF13B),partial,Biotinylated (Active) (CSB-MP897523HU1-B)

Validated Data

High Purity Validated
by SDS-PAGE

Greater than 92% as determined by SDS-PAGE.

Excellent TNFSF13B (Biotinylated)-BCMA Binding Bioactivity Validated by Functional ELISA

Immobilized human BCMA at 5 μg/ml can bind Biotinylated human TNFSF13B, the EC₅₀ is 0.1752-0.3657 ng/ml.

High TNFSF13B (Biotinylated)-TNFRSF13C Binding Bioactivity Validated by Functional ELISA

Immobilized human TNFRSF13C at 2 μg/ml can bind Biotinylated human TNFSF13B, the EC₅₀ is 0.2699-0.5613 ng/ml.