Recombinant Mouse Tumor necrosis factor ligand superfamily member 13 (Tnfsf13)

1. p40, a Lactobacillus rhamnosus-derived protein upregulates EGFR-dependent APRIL expression in intestinal epithelial cells, which may contribute to promoting IgA production PMID: 27353252
2. this study identifies APRIL as a new target involved in B-cell activation, in the maintenance of plasma cell survival and subsequent increased autoantibody production that sustains lupus development in mice PMID: 28267197
3. Our data indicate that APRIL contributes to fibrotic scar formation after spinal cord injury by mediating the inflammatory response PMID: 27098833
4. this is the first study to implicate the APRIL signal transduction pathway in the pathogenesis of nephrogenic IgA production. Moreover, our findings identify APRIL as a potential target of therapy. PMID: 26348210
5. the elevated presence of APRIL and BLyS in B cell-rich areas of chronically inflamed gingiva suggests that these cytokines may contribute to bone loss by promoting the survival and persistence of RANKL-expressing B cells/plasma cells. PMID: 26150532
6. myelopoiesis dysregulation characterized by an increased proportion of precursor cells occurs in MM patients. Such dysregulation correlates with a stable expression of the MM-promoting factor APRIL in infiltrated BM. PMID: 25753925
7. B cell activating factor (BAFF) and a proliferation inducing ligand (APRIL) mediate CD40-independent help by memory CD4 T cells in transplantations. PMID: 25496308
8. Heteromers consisting of one BAFF and two APRIL bind to receptor TACI, BCMA but not to BAFFR. PMID: 25953898
9. Immunization of mice with a DNA vaccine encoding BAFF or APRIL multitrimers, together with interleukin 12 and membrane-bound HIV-1 Env gp140, induced neutralizing antibodies against tier 1 and tier 2 (vaccine strain) viruses. PMID: 25631080
10. APRIL mediates peritoneal B-1 cell homeostasis. PMID: 24512739
11. APRIL selectively enhances axonal growth by activating ERK signaling and PI3-kinase/Akt/GSK-3beta signaling. PMID: 24444792
12. Data indicate that APRIL expression accelerates the onset of TCL1-driven leukemia formation mainly through TACI activation. PMID: 24100449
13. The ability of TACI-Fc to activate reverse signalling through BAFF and APRIL, was investigated. PMID: 23620746
14. CD1d-restricted invariant NKT cell-derived BAFF and APRIL each contribute to survival of plasma cells induced by immunization. PMID: 23797666
15. The TNF family member APRIL dampens collagen-induced arthritis. PMID: 23178293
16. NF-kappaB mediates APRIL-induced HoxC4 transcription. PMID: 23178148
17. APRIL is dispensable for the development of full-blown SLE in NZM mice. PMID: 22127792
18. Grafted human colorectal tumor growth and metastasis were inhibited while tumor cell apoptosis and necrosis were induced after in vivo APRIL siRNA injection into nude mice. PMID: 22170570
19. April production, both in the human and mouse systems, peaks in myeloid precursor cells, before dropping in fully mature granulocytes. PMID: 21642598
20. Disruption of heparan sulfate proteoglycan conformation perturbs B-cell maturation and APRIL-mediated plasma cell survival. PMID: 21471524
21. APRIL inhibits allergic lung inflammation by suppressing c-maf expression and directly reducing IL-13 production in CD4+ T cells. PMID: 21182087
22. Review. Dendritic cell-derived TNF-family ligand APRIL enhances plasmablast survival and differentiation to plasma cells. PMID: 12354377
23. Results describe the crystal structure of a proliferation-inducing ligand, APRIL. PMID: 15451660
24. significantly increased APRIL levels in sera of B cell chronic lymphoid leukemia (B-CLL) patients, indicating that APRIL promotes onset of B-1-associated neoplasms PMID: 15488762
25. heparan sulfate proteoglycans (HSPG) serve as a receptor for APRIL or that HSPG binding allows APRIL to interact with a receptor that promotes tumor growth PMID: 15846369
26. B cell activation factor from the TNF family and proliferation-inducing ligand can modulate the survival of developing B cells in the bone marrow PMID: 16293214
27. Review. The splice variants, binding specificities, structural determinants for ligand selectivity, and signaling pathways are reviewed. PMID: 16914324
28. Review. APRIL interactions with BCMA likely govern memory B cell populations. PMID: 16919470
29. Review. Direct BAFF/APRIL signalling in T cells and/or T cell modulation in response to a BAFF-modified B cell compartment may play an important role in inflammation and immunomodulation. PMID: 16931039
30. overexpression of BAFF and APRIL may contribute to the development of autoimmune disease PMID: 17947668
31. APRIL is a critical signal for plasmablast survival that is poorly expressed in the early-life bone marrow compartment. PMID: 18180376
32. Long-lived memory B cell survival and function are completely independent of APRIL (a proliferation-inducing ligand) or BAFF (B cell-activating factor of the TNF family). Either APRIL or BAFF supports the survival of bone marrow plasma cells in vivo. PMID: 18322170
33. These results indicate that APRIL affects specific aspects of the anti-influenza response, but plays a limited role in disease recovery. PMID: 18471884
34. Erythroleukemia in APRIL transgenic mice is characterized by low hematocrits and grossly enlarged spleens with an increased percentage of erythroid precursors. PMID: 18483203
35. in APRIL(-/-) mice, the incidence of collagen-induced arthritis was significantly reduced compared with WT mice in parallel with diminished levels of antigen-specific IgG2a autoantibody and IL-17 production PMID: 19016524
36. APRIL blockade resulted in a significant decrease in IL-4 and eotaxin mRNA and IL-4 and KC protein levels in total homogenates and BAL fluid. PMID: 19037968
37. IL-4 up-regulates APRIL expression through two divergent pathways in mouse macrophages, p38MAPK-CREB and p38MAPK-Stat6. PMID: 19427796

Show More

Hide All

KEGG: mmu:69583

STRING: 10090.ENSMUSP00000018896

UniGene: Mm.8983