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| Product Type | Recombinant Protein |
| Uniprot No. | A9RA84 |
| Species | Papio anubis (Olive baboon) |
| Gene Names | HMGB1 |
| Protein Names | Recommended name: High mobility group protein B1 Alternative name(s): High mobility group protein 1 Short name= HMG-1 |
| Storage | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. |
| Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
| Function | Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance. Has proangiogenic activity. May be involved in platelet activation. Binds to phosphatidylserine and phosphatidylethanolamide. Bound to RAGE mediates signaling for neuronal outgrowth. May play a role in accumulation of expanded polyglutamine (polyQ) proteins. |
| Subcellular Location | Nucleus, Chromosome, Cytoplasm, Secreted, Cell membrane, Peripheral membrane protein, Extracellular side, Endosome, Endoplasmic reticulum-Golgi intermediate compartment |
| Protein Families | HMGB family |
| Database Links |
UniGene: Pan.761 |
| Pathway |
Autophagy
Necroptosis DNA repair pathway |
| Product Name | Recombinant Papio anubis High mobility group protein B1(HMGB1),Yeast |
| Code | CSB-YP434996ERI |
| Size | Pls inquiry other sizes |
| Source | Yeast |
| Purity | >85% (SDS-PAGE) |
| Tag Info | The following tags are available. N-terminal His-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
| Sequence | GKGDPKKPR GKMSSYAFFV QTCREEHKKK HPDASVNFSE FSKKCSERWK TMSAKEKGKF EDMAKADKAR YEREMKTYIP PKGETKKKFK DPNAPKRPPS AFFLFCSEYR PKIKGEHPGL SIGDVAKKLG EMWNNTAADD KQPYEKKAAK LKEKYEKDIA AYRAKGKPDA AKKGVVKAEK SKKKKEEEED EEDEEDEEEE EDEEDEDEEE DDDDE |
| Expression Region | 2-215 |
| Protein Description | Full Length of Mature Protein |
| Storage Buffer | Tris-based buffer,50% glycerol |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Product Name | Recombinant Papio anubis High mobility group protein B1(HMGB1),E.coli |
| Code | CSB-EP434996ERI |
| Size | Pls inquiry other sizes |
| Source | E.coli |
| Purity | >85% (SDS-PAGE) |
| Tag Info | The following tags are available. N-terminal His-tagged and C-terminal Myc-tagged N-terminal His-SUMO-tagged and C-terminal Myc-tagged N-terminal His-B2M-tagged and C-terminal Myc-tagged N-terminal His-GST-tagged and C-terminal Myc-tagged N-terminal His-tagged N-terminal His-SUMO-tagged N-terminal His-B2M-tagged N-terminal His-GST-tagged N-terminal GST-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
| Sequence | GKGDPKKPR GKMSSYAFFV QTCREEHKKK HPDASVNFSE FSKKCSERWK TMSAKEKGKF EDMAKADKAR YEREMKTYIP PKGETKKKFK DPNAPKRPPS AFFLFCSEYR PKIKGEHPGL SIGDVAKKLG EMWNNTAADD KQPYEKKAAK LKEKYEKDIA AYRAKGKPDA AKKGVVKAEK SKKKKEEEED EEDEEDEEEE EDEEDEDEEE DDDDE |
| Expression Region | 2-215 |
| Protein Description | Full Length of Mature Protein |
| Storage Buffer | Tris-based buffer,50% glycerol |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Product Name | Recombinant Papio anubis High mobility group protein B1(HMGB1),Baculovirus |
| Code | CSB-BP434996ERI |
| Size | Pls inquiry other sizes |
| Source | Baculovirus |
| Purity | >85% (SDS-PAGE) |
| Tag Info | The following tags are available. N-terminal His-tagged and C-terminal Myc-tagged N-terminal His-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
| Sequence | GKGDPKKPR GKMSSYAFFV QTCREEHKKK HPDASVNFSE FSKKCSERWK TMSAKEKGKF EDMAKADKAR YEREMKTYIP PKGETKKKFK DPNAPKRPPS AFFLFCSEYR PKIKGEHPGL SIGDVAKKLG EMWNNTAADD KQPYEKKAAK LKEKYEKDIA AYRAKGKPDA AKKGVVKAEK SKKKKEEEED EEDEEDEEEE EDEEDEDEEE DDDDE |
| Expression Region | 2-215 |
| Protein Description | Full Length of Mature Protein |
| Storage Buffer | Tris-based buffer,50% glycerol |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Product Name | Recombinant Papio anubis High mobility group protein B1(HMGB1),Mammalian cell |
| Code | CSB-MP434996ERI |
| Size | Pls inquiry other sizes |
| Source | Mammalian cell |
| Purity | >85% (SDS-PAGE) |
| Tag Info | The following tags are available. N-terminal His-tagged and C-terminal Myc-tagged N-terminal His-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
| Sequence | GKGDPKKPR GKMSSYAFFV QTCREEHKKK HPDASVNFSE FSKKCSERWK TMSAKEKGKF EDMAKADKAR YEREMKTYIP PKGETKKKFK DPNAPKRPPS AFFLFCSEYR PKIKGEHPGL SIGDVAKKLG EMWNNTAADD KQPYEKKAAK LKEKYEKDIA AYRAKGKPDA AKKGVVKAEK SKKKKEEEED EEDEEDEEEE EDEEDEDEEE DDDDE |
| Expression Region | 2-215 |
| Protein Description | Full Length of Mature Protein |
| Storage Buffer | Tris-based buffer,50% glycerol |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
HMGB1 Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA01604A0Rb | HMGB1 Antibody | Human, Mouse | ELISA, WB, IHC |
HMGB1 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA01604B0Rb | HMGB1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA01604C0Rb | HMGB1 Antibody, FITC conjugated | Human | ELISA |
| CSB-PA01604D0Rb | HMGB1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA010553GA01HU | HMGB1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA049959 | HMGB1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA000149 | Acetyl-HMGB1 (K12) Antibody | Human,Mouse,Rat | WB,ELISA |
| CSB-PA005927 | HMGB1 Antibody | Human,Mouse,Rat | WB,ELISA |
| CSB-PA995991 | HMGB1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA225274 | HMGB1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
HMGB1 Antibodies for
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA002937 | HMGB1 Antibody | Human,Mouse,Rat | WB,IHC,IF,ELISA |
HMGB1 Antibodies for Arabidopsis thaliana (Mouse-ear cress)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA523735XA01DOA | HMGB1 Antibody | Arabidopsis thaliana | ELISA, WB (ensure identification of antigen) |
HMGB1 Antibodies for Gallus gallus (Chicken)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA590934XA01CH | HMGB1 Antibody | Gallus gallus (Chicken) | ELISA, WB (ensure identification of antigen) |
HMGB1 Proteins for Bos taurus (Bovine)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP010553BO CSB-EP010553BO CSB-BP010553BO CSB-MP010553BO |
Recombinant Bovine High mobility group protein B1(HMGB1) | Yeast E.coli Baculovirus Mammalian cell |
HMGB1 Proteins for Sus scrofa (Pig)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP010553PI CSB-EP010553PI CSB-BP010553PI CSB-MP010553PI |
Recombinant Pig High mobility group protein B1(HMGB1) | Yeast E.coli Baculovirus Mammalian cell |
HMGB1 Proteins for Mus musculus (Mouse)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP010553MO CSB-EP010553MO CSB-BP010553MO CSB-MP010553MO |
Recombinant Mouse High mobility group protein B1(Hmgb1) | Yeast E.coli Baculovirus Mammalian cell |
HMGB1 Proteins for Rattus norvegicus (Rat)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP010553RA CSB-EP010553RA CSB-BP010553RA CSB-MP010553RA |
Recombinant Rat High mobility group protein B1(Hmgb1) | Yeast E.coli Baculovirus Mammalian cell |
HMGB1 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP010553HU | Recombinant Human High mobility group protein B1(Hmgb1) | Yeast |
| CSB-RP016044h | Recombinant Human High mobility group protein B1(HMGB1),partial | E.coli |
| CSB-EP010553HU CSB-BP010553HU CSB-MP010553HU |
Recombinant Human High mobility group protein B1(HMGB1) | E.coli Baculovirus Mammalian cell |
HMGB1 Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP362058DXU CSB-EP362058DXU CSB-BP362058DXU CSB-MP362058DXU |
Recombinant Cricetulus griseus High mobility group protein B1(HMGB1) | Yeast E.coli Baculovirus Mammalian cell |
HMGB1 Proteins for Arabidopsis thaliana (Mouse-ear cress)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP523735DOA CSB-EP523735DOA CSB-BP523735DOA CSB-MP523735DOA |
Recombinant Arabidopsis thaliana High mobility group B protein 1(HMGB1) | Yeast E.coli Baculovirus Mammalian cell |
HMGB1 Proteins for Callithrix jacchus (White-tufted-ear marmoset)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP533334CYL CSB-EP533334CYL CSB-BP533334CYL CSB-MP533334CYL |
Recombinant Callithrix jacchus High mobility group protein B1(HMGB1) | Yeast E.coli Baculovirus Mammalian cell |
HMGB1 Proteins for Plecturocebus moloch (Dusky titi monkey) (Callicebus moloch)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP541463CYE CSB-EP541463CYE CSB-BP541463CYE CSB-MP541463CYE |
Recombinant Callicebus moloch High mobility group protein B1(HMGB1) | Yeast E.coli Baculovirus Mammalian cell |
HMGB1 Proteins for Equus caballus (Horse)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP600961HO CSB-EP600961HO CSB-BP600961HO CSB-MP600961HO |
Recombinant Horse High mobility group protein B1(HMGB1) | Yeast E.coli Baculovirus Mammalian cell |
HMGB1 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP703137MOV CSB-EP703137MOV CSB-BP703137MOV CSB-MP703137MOV |
Recombinant Macaca fascicularis High mobility group protein B1(HMGB1) | Yeast E.coli Baculovirus Mammalian cell |
HMGB1 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP751094DO CSB-EP751094DO CSB-BP751094DO CSB-MP751094DO |
Recombinant Dog High mobility group protein B1(HMGB1) | Yeast E.coli Baculovirus Mammalian cell |
HMGB1 cDNA for Papio anubis (Olive baboon)
| Code | Product Name | Vector | Accession NO. |
|---|---|---|---|
| CSB-CL434996ERI | HMGB1 | pUC | NM_001168909.1 |
HMGB1 cDNA for Equus caballus (Horse)
| Code | Product Name | Vector | Accession NO. |
|---|---|---|---|
| CSB-CL600961HO | HMGB1 | pUC | NM_001081835.1 |
HMGB1 cDNA for Canis lupus familiaris (Dog) (Canis familiaris)
| Code | Product Name | Vector | Accession NO. |
|---|---|---|---|
| CSB-CL751094DO | HMGB1 | pUC | NM_001002937.1 |
HMGB1 ELISA Kit for Bos taurus (Bovine)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-EL010553BO | Bovine High mobility group protein B1(HMGB1) ELISA kit | serum, plasma, tissue homogenates | 0.78 ng/mL |
HMGB1 ELISA Kit for Canis lupus familiaris (Dog) (Canis familiaris)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-EL010553DO | Dog High mobility group protein B1(HMGB1) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 0.078 ng/mL |
HMGB1 ELISA Kit for Equus caballus (Horse)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-EL010553HO | Horse High mobility group protein B1(HMGB1) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 1.95 ng/mL |
HMGB1 ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E08223h | Human High mobility group protein B1,HMGB-1 ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 19.5 pg/mL |
HMGB1 ELISA Kit for Mus musculus (Mouse)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E08225m | Mouse High mobility group protein B1,HMGB-1 ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 3.9 pg/mL |
HMGB1 ELISA Kit for Sus scrofa (Pig)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-EL010553PI | Pig High mobility group protein B1(HMGB1) ELISA kit | serum, plasma, tissue homogenates | 0.078 ng/mL |
HMGB1 ELISA Kit for Rattus norvegicus (Rat)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E08224r | Rat High mobility group protein B1,HMGB-1 ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates | 15.6 pg/mL |
Recombinant Clostridium tetani Tetanus toxin(tetX),partial
Express system: E.coli
Species: Clostridium tetani (strain Massachusetts / E88)
Recombinant Human Tyrosine-protein kinase JAK1(JAK1),partial
Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Human Cytochrome c-type heme lyase(HCCS)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Ras-related protein Rab-11A(RAB11A)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Serum amyloid P-component(APCS)
Express system: E.coli
Species: Homo sapiens (Human)
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