HMGB1 Research Reagents

High mobility group protein B1 is a protein in humans that is encoded by HMGB1 gene. Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury

The following HMGB1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

HMGB1 Antibodies

HMGB1 Antibodies for Homo sapiens (Human)

HMGB1 Antibodies for Arabidopsis thaliana (Mouse-ear cress)

HMGB1 Antibodies for Gallus gallus (Chicken)

HMGB1 Antibodies for Rattus norvegicus (Rat)

HMGB1 Antibodies for Mus musculus (Mouse)

HMGB1 Proteins

HMGB1 Proteins for Bos taurus (Bovine)

HMGB1 Proteins for Sus scrofa (Pig)

HMGB1 Proteins for Mus musculus (Mouse)

HMGB1 Proteins for Rattus norvegicus (Rat)

HMGB1 Proteins for Homo sapiens (Human)

HMGB1 Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)

HMGB1 Proteins for Papio anubis (Olive baboon)

HMGB1 Proteins for Arabidopsis thaliana (Mouse-ear cress)

HMGB1 Proteins for Callithrix jacchus (White-tufted-ear marmoset)

HMGB1 Proteins for Plecturocebus moloch (Dusky titi monkey) (Callicebus moloch)

HMGB1 Proteins for Equus caballus (Horse)

HMGB1 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

HMGB1 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

HMGB1 ELISA Kit

HMGB1 ELISA Kit for Canis lupus familiaris (Dog) (Canis familiaris)

HMGB1 ELISA Kit for Homo sapiens (Human)

HMGB1 ELISA Kit for Mus musculus (Mouse)

HMGB1 ELISA Kit for Sus scrofa (Pig)

HMGB1 ELISA Kit for Rattus norvegicus (Rat)

HMGB1 Background

High mobility group protein B1 is a protein in humans that is encoded by the HMGB1 gene. The HMGB1 protein is a multifunctional redox-sensitive protein with various roles in different cellular compartments. In the nucleus, it is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair, and genome stability. And it is proposed to be a universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. HMGB1 acts as danger-associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury

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