Name: Recombinant Pig Appetite-regulating hormone(GHRL)
Brand: CUSABIO
SKU: 863901PI

Product Details

Purity	>85% (SDS-PAGE)
Target Names	GHRL
Uniprot No.	Q9GKY5
Alternative Names	GHRLAppetite-regulating hormone; Growth hormone secretagogue; Growth hormone-releasing peptide; Motilin-related peptide) [Cleaved into: Ghrelin; Obestatin]
Species	Sus scrofa (Pig)
Expression Region	25-52
Target Protein Sequence	GSSFLS PEHQKVQQRK ESKKPAAKLK PR
Protein Length	Cytoplasmic domain
Tag Info	The following tags are available. N-terminal His-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form	Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization	Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs	Protein FAQs
Storage Condition	Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time	Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time. Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet	Please contact us to get it.

Target Background

Function	Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.; Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.
Gene References into Functions	These expression data may indicate that factors other than ghrelin and leptin are more involved in the regulation of feed intake in pigs apparently acclimated to heat stress. PMID: 27264891 slc30A8 colocalizes with ghrelin and motilin in the gastrointestinal tract of pigs PMID: 26388512 Studied an alternative vascular approach to the modulation of gastric ghrelin levels.. PMID: 25294792 Obestatin enhances proliferation and differentiation of preadipocytes promoting PPARgamma and C/EBPa expression, and inhibiting preadipocyte apoptosis by decreasing expression of Caspase-3, Caspase-7 and Caspase-9. PMID: 24534601 The expression of ghrelin in the digestive tract of low birth weight and normal weight piglets is reported. PMID: 24237675 Data suggest that a dietary factor (here, high levels of dietary copper) is able to up-regulate expression of ghrelin in the fundic gland of growing pigs; the diets tested in this study also increase feed intake and promote weight gain. PMID: 22911428 Ghrelin immunolocalization in the gastrointestinal tract of pigs at different ages were studied and it was concluded that gastric ghrelin expression is not related merely to age but could also potentially be influenced by food intake. PMID: 22281862 BsrI polymorphism at the ghrelin gene locus is potentially associated with carcass and meat quality traits. PMID: 21669497 Plasma concentrations of ghrelin were greater before feeding and decreased after feeding in pigs fed once per day; there was no consistent pattern to ghrelin secretion in the ad libitum fed group. PMID: 20399063 glucose output by primary porcine hepatocytes in suspension culture, after incubation with acylated ghrelin (AG), unacylated ghrelin (UAG), and hexarelin (HEX). PMID: 15536157 Immunization against ghrelin was associated with increased antibody titers, decreased voluntary food consumption, and decreased body weight gain by pigs. PMID: 16793235 ghrelin mRNA expression is up-regulated 10 days after weaning in the gastric fundus of piglets, coinciding with the increase of H(+)-K(+)-ATPase mRNA expression and activity PMID: 16920167 growth hormone stimulated both ghrelin synthesis and secretion in the ovarian follicles PMID: 17951088 Ghrelin requires activation of the NOS/NO route, and its subsequent GC/cGMP signal transduction pathway, as necessary steps to induce GH secretion from somatotrophs. PMID: 18208548 Expression of ghrelin mRNA is affected by estrus in the hypothalamus, pituitary gland and ovary. PMID: 18295988 circulating total plasma ghrelin concentrations in the pig appear to be influenced by chronic changes in energy balance rather than the feeding pattern per se. PMID: 18434347 provides novel evidence that ghrelin has a modulatory effect in the ovary PMID: 19212011 Show More Hide All
Subcellular Location	Secreted.
Protein Families	Motilin family
Database Links	KEGG: ssc:396728 STRING: 9823.ENSSSCP00000012327 UniGene: Ssc.440

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Code	CSB-YP863901PI
Size	Pls inquire
Source	Yeast
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Code	CSB-EP863901PI
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Source	E.coli
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Code	CSB-EP863901PI-B
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Source	E.coli
Conjugate	Avi-tag Biotinylated E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code	CSB-BP863901PI
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Source	Baculovirus
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Code	CSB-MP863901PI
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Source	Mammalian cell
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Recombinant Pig Appetite-regulating hormone(GHRL)

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