Recombinant Rabbit Monocyte differentiation antigen CD14(CD14)

Code CSB-YP638942RB
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Source Yeast
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Code CSB-EP638942RB
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Source E.coli
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Code CSB-EP638942RB-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP638942RB
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Source Baculovirus
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Code CSB-MP638942RB
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names CD14
Uniprot No. Q28680
Alternative Names CD14Monocyte differentiation antigen CD14; Myeloid cell-specific leucine-rich glycoprotein; CD antigen CD14
Species Oryctolagus cuniculus (Rabbit)
Expression Region 18-342
Target Protein Sequence STD TPEPCELDDD DIRCVCNFSD PQPDWSSALQ CMPAVQVEMW GGGHSLEQFL RQADLYTDQR RYADVVKALR VRRLTVGAVQ VPAPLLLGVL RVLGYSRLKE LALEDIEVTG TAPPPPPLEA TGPALSTLSL RNVSWPKGGA WLSELQQWLK PGLQVLNIAQ AHTLAFSCEQ VRTFSALTTL DLSENPGLGE RGLVAALCPH KFPALQDLAL RNAGMKTLQG VCAALAEAGV QPHHLDLSHN SLRADTQRCI WPSALNSLNL SFTGLQQVPK GLPAKLNVLD LSCNKLNRAP QPGELPKVVN LSLDGNPFLV PGASKLQEDL TN
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-).
Gene References into Functions
  1. VB-201 may counter inflammation where TLR-2 and/or CD14 complicity is essential, and is therefore beneficial for the treatment of atherosclerosis. PMID: 24116867
Subcellular Location Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Membrane raft. Golgi apparatus.
Database Links

KEGG: ocu:100008983

STRING: 9986.ENSOCUP00000003648

UniGene: Ocu.1842

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