Recombinant Rabbit Protein disulfide-isomerase(P4HB)

Code CSB-YP017342RB
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Source Yeast
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Code CSB-EP017342RB
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Source E.coli
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Code CSB-EP017342RB-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP017342RB
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Source Baculovirus
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Code CSB-MP017342RB
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names P4HB
Uniprot No. P21195
Alternative Names P4HB; PDIA1; Protein disulfide-isomerase; PDI; EC 5.3.4.1; Cellular thyroid hormone-binding protein; Prolyl 4-hydroxylase subunit beta; p55
Species Oryctolagus cuniculus (Rabbit)
Expression Region 19-509
Target Protein Sequence WA AEEEDNVLVL KSSNFAEELA AHKHLLVEFY APWCGHCKAL APEYAKAAGK LKAEGSDIRL AKVDATEESD LAQQYGVRGY PTIKFFKNGD TASPKEYTAG READDIVNWL KKRTGPAATT LADSAAAESL VESSEVAVIG FFKDVESDAA KQFLLAAEAT DDIPFGLTAS SDVFSRYQVH QDGVVLFKKF DEGRNNFEGE VTKEKLLDFI KHNQLPLVIE FTEQTAPKIF GGEIKTHILL FLPRSAADHD GKLSGFKQAA EGFKGKILFI FIDSDHADNQ RILEFFGLKK EECPAVRLIT LEEEMTKYKP ESDELTAEGI TEFCQRFLEG KIKPHLMSQE LPEDWDRQPV KVLVGKNFEE VAFDEKKNVF VEFYAPWCGH CKQLAPIWDK LGETYKEHQD IVIAKMDSTA NEVEAVKVHS FPTLKFFPAG PGRTVIDYNG ERTLDGFKKF LESGGQDGAG DEDGLEDLEE AEEPDLEEDD DQKAVRDEL
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration.
Subcellular Location Endoplasmic reticulum. Endoplasmic reticulum lumen. Melanosome. Cell membrane; Peripheral membrane protein.
Protein Families Protein disulfide isomerase family
Database Links

KEGG: ocu:100328595

UniGene: Ocu.5912

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